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Opioids Affinity of different oppies

El Barto

Bluelighter
Joined
Jul 3, 2013
Messages
117
Location
España, iurop : P
Well, id like to know the differents affinitys of the oppies, to know when is worthy to mix them, when not

per example, if having 16 mg of bupe in system, using H or oxy would be a waste because bupe blocking cause it has more affinity. Not about the power of any oppiate, but about the affinity

fentanyl(really short HL)>bupe(very long HL)>methadone(long HL)>heroin ( short HL)

bupe is known to be have one of the bigger affinitys. Someone told on the fentanyl thread that fenta has more affinity than bupe

methadone blocks heroin, so methadone has more affinity

can anyother help? where to place morphine, oxy, opium etc
 
I like when I have no idea the answer to something, search for under 30seconds and find the answer, and post it in a cool minute total.

Basically I own at search engine.

http://pdsp.med.unc.edu/pdsp.php?knowID=&kiKey=&receptorDD=&receptor=&speciesDD=&species=&sourcesDD=&source=&hotLigandDD=&hotLigand=&testDDRadio=testDDRadio&testLigandDD=988&testLigand=&referenceDD=&reference=&KiGreater=&KiLess=&kiAllRadio=all&doQuery=Submit+Query

Or since that doesn't want to hyperlink, http://www.bluelight.ru/vb/threads/661568-Opiates-Opioids-affinity-for-each-receptor-Lets-build-a-table-chart!!!!

Second post
 
this chart is cool info, thkx for sharing


anyway, this dosent answer my question, if i am not wrong

im not questioning wich oppies are agonist or not, but a comparasion between them related with its affinity

i mean, the affinity of bupre shown there:

- μ - Mu = Affinity: 0.9nM Activity: Partial Agonist, Efficacy: 34%

seems lower than the heroin:


- μ - Mu = Affinity: 4.55nM Activity: Agonist, Efficacy: 75%

but we know bupre has more affinity than heroin ( like you take boths at the same time, and bupre is like a better key for the receptor than the H so it will be the bupre the one added to the receptors)

so, this info is very useful (thkx again for sharing), but dosent answer my question. if it does, please help me to find where it is, i dont find there in the link you have posted
 
I maybe off the mark here but im pretty certain that Ki values work on the method that the lower the number equals a higher affinity.
Opium could be a complicated one to factor in though because its a number of active alkaloids, not just one. But if we say that morphine is likely to be the dominant alkaloid in opium, then i would say its affinity is the same as morphines.
 
You asked for affinities mayne. nM means nanometers. Smaller is closer.

Basically you just flip everything around. Closer to zero trumps higher numbers.
 
ok, so bupre having less nM than H means it has more affinity, and not less?

Like there is some inverse relation with this nM?

If so, yes it does answer my question very clearly :)

i dont understund this:

Basically you just flip everything around
, and online translators dosent help me


@bunge: thkx my friend, so in short words, the less nM, the more affinity? Just to be sure about it
 
Yep that's about it. It's not a % , that nM figure. It's a measure of distance.
 
Affinities are measured in moles (amount of compound needed to displace a ligand), they aren't a measure of distance.

Smaller numbers are tighter binding.
 
Ur taking that out of context IMHO.

What can I say, when you're right, you're right.
 
Ur taking that out of context IMHO.

i dont think so, its not the same distance than amount, is important that us, the users, to have proper info. So i say thkx to this correct info

This is not about who is right or not in the discussion, but about users having the correct information
 
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