ADs that act on opiate receptors

[neurogal]

I recently learned there are several antidepressants in trials that act on opiate receptors while blocking highly pleasurable sensations in order to reduce addiction/abuse. One in particular that I'm interested in is currently known as CERC 501 (bupe/samidorphan). Unfortunately it's been essentially shot down for now by the FDA for trial methodology issues among other concerns. Has anyone researched or been following ADs involving opiate receptor(s)? Kappa blockers are of particular interest.

 

[dopamimetic]

I've been on bupe without samidorphan without physical (mu) opioid tolerance but severe depression due to my disso habit and all it did were some hefty side effects but your mileage may vary.

Tianeptine is another one mainly involving mu receptors (seemingly).

If you ask me the most interesting ones would be selective delta agonists cause my experiences with bromadol/BDPC** had something unique with them. Like fluid silk. Very uplifting.

** (no its not 10,000x morphine... crazy potent nevertheless, so don't mess with it. I had my day in ER too cause of mixing it, sigh)

 

[clubcard]

BDPC is a mu/NOP ligand AFAIK. Gruenenthal published extensive QSAR studies.

 

[AlphaMethylPhenyl]

suboxone of what I know. guessing here that salvinorum a leads to down-regulation after the hallucinogenic experience.