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adrenochrome article request

E

EN21

Bluelighter
Joined
Nov 17, 2005
Messages
139
Hi, folks!

Sorry for annoying you with article requests, but has anybody access to Smythies's adrenochrome review?

The adrenochrome hypothesis of schizophrenia revisited.
Smythies J.
Neurotox Res. 2002 Mar;4(2):147-50.

Or does anybody know any other scientific and up to date information on this magic adrenochrome stuff? It is sometimes referred as a kind of excreted hormone after mescaline ingestion. People try to explain the very delayed onset (up to 2 h) of mescaline that way.
Anybody heared about it?

Thanks!
 
I'm reviving this thread because of the Wiki article I just read:

Megavitamin therapy advocates Abram Hoffer and Humphry Osmond claimed that adrenochrome is a hallucinogenic substance and may be responsible for schizophrenia and other mental illnesses. In what they called the "adrenochrome hypothesis", they speculated that megadoses of vitamin C and niacin could cure schizophrenia by reducing brain adrenochrome. There has been controversy about whether adrenochrome can be classified as a psychotropic drug.
Click to expand...

Is there any such hard evidence, or is this less than within range for possible conjecture for being in any way active?
 
Well I highly doubt that it is something that you would want to consume. The semicarbazone appears to be active in humans but not as a hallucinogen. There is a lot of conflicting data.

Entry in Adam Gottlieb's Legal Highs (1973):

ADRENOCHROME SEMICARBAZONE -- 3-hydroxy-1-methyl-5,6-indolinedione semicarbazone.
Material: Oxidized epinephrine (adrenaline) with semicarbazide.
Usage: 100 mg is thoroughly dissolved in just enough alcohol, melted fat (butter), or vegetable oil and ingested. Because of its poor solubility in water these must be used to aid absorption.
Effects: Physical stimulating, feeling of well-being, slight reduction of thought processes.
Contraindications: None noted.
Acts as a systemic hemostatic preventing capillary bleeding during injury. Adrenochrome causes chemically induced schizophrenia. Its semicarbazone does not.
Supplier: CS.

http://www.erowid.org/chemicals/adrenochrome/adrenochrome_info1.shtml

That was from 1973 though and I am not aware of any recent studies on adrenochrome or adrenolutin. I would take any research into the area with an extremely large spoonful of salt. It has been readily available for sale from some of the major scientific chemical supply companies for some time now and I'm sure that Hunter S. Thompson's cult-like following would have been mass producing it in droves if it actually did anything useful. Even from that one quote it sounds like a very weak stimulant at best and snake oil at worst.
 
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