Adderall Neurotoxicity

[rickolasnice]

^ Awsome

*Facepalm*

 

[sheepie]

I was very much awake, but all I could do was stare at my computer screen think about weird existencial rubish very deeply.

been there with ritalin haha. not fun :/
i started thinking about depressive thoughts in the middle of class such as "i should just kill myself... human existence is pointless anyway". that's what stims do to you.

anyway, I can't answer your question, but good luck!

 

[FractalStructure]

About two weeks ago I was pretty depressed and wasn't doing a whole lot (even though on adderall) and needed to write a paper for a friend, so I stayed up all night to write it. Only problem was that instead of feeling great and getting the paper done beautifully, I just felt horrible. I was very much awake, but all I could do was stare at my computer screen think about weird existencial rubish very deeply. I ended up taking like 50mg throughout the night and it just got worse. I'm not sure if this was a mixed episode or a psychotic break or what

I wouldnt consider this "damage", I just think you're getting a bit edgy from the constant amph use (and yes, I have felt like that too, I had something to do, I got spun and ended up just thinking about shit...). At this point, I'd suggest you take a break, because the more you do it, the harder the toll on your body and brain will be. But i wouldnt be worried about neurotoxicity thats irreversible if you dont keep doing it.

Its debated anyway, but most people will say that in GENERAL amphetamines CAN cause neurotoxicity if abused for a long time/high doses.

 

[allalong]

You may have developed Obsessive-Compulsive Disorder esque symptoms from amphetamine use.
If you have access to methadone, try dosing 30mg once a day for several days, and your symptoms will start improving - or even be cured entirely.

Why would the methadone thing help?

Excuse my ignorance on the subject, but wouldn't that just cause him to become addicted to methadone and, assuming no opiate tolerance, sick every day for the first few days?

 

[Chauncey_GARDENer]

I have been scripted Adderall for over two years now with (prescribed) doses ranging from 20mg to 60mg XR.

IMO marijuana is the best way to combat amphetamine psychosis. I have smoked weed pretty much non stop since I have started my XR regimen, and I feel that it positively affects the stim "focus" in many ways. There is just something about that edgy amphetamine feeling that makes me want to get blazed... Really bad!! The funny thing is, when I don't take the capsules I almost have no desire to smoke cannabis... but I usually still do.

THC has been found to be neuroprotective under certain circumstances, so it wouldn't be such a big leap to say that herb might protect the brain from amp induced oxidative stress. But i'm not a doctor sooooo

 

[Soap MacTavish]

yeah somehow my doc (who is clearly a croaker writing scrips for junkies) writes me a scrip for 60 X 30mg XR + 30 X 20mg IR per month. According to the script I am supposed to take a 30 XR when I get up, a 30 XR at around 2, and a 20 IR around 6 to hopefully last me through the evening... which it never does.... because I never sleep... and it's all just never enough anyway. Got to network to keep the supply maintained. But that all went totally by the wayside once PV entered my life, I tossed the adderal tabs in a drawer and didn't give 2 shits about them anymore. In fact there was nothing at all I gave 2 shits about after the PV... except the PV.

 

[Colmes]

While I believe time does a great deal in letting the brain readjust to not having a crutch which it uses to produce certain neurochemicals needed to get to that equilibrium that had become the new normal. However that being said, and having too much experience with dextroamphetamine, over a year later; my brain has undeniably changed. I am sure a SPECT scan would prove that when stimulated; certain parts of the brain such would not respond as strongly as a healthy brain. I'm not talking atrophy, but a permanent change in the healthy amount of dopamine...serotonin..and the like; naturally produced .

 

[SpunkySkunk347]

Why would the methadone thing help?

Excuse my ignorance on the subject, but wouldn't that just cause him to become addicted to methadone and, assuming no opiate tolerance, sick every day for the first few days?

1. the slight NMDA antagonistic effects serve as a sort of "reset" function for the brain's neurotransmitter systems

2. Opiates have been shown to be a highly effective cure/treatment for obsessive compulsive disorder (and symptoms associated wiht OCD) -- although due to their addictive nature, and opiates being an unorthodox treatment for any mental disorder, opiate therapy for OCD is almost entirely unheard of

 

[SpunkySkunk347]

yeah somehow my doc (who is clearly a croaker writing scrips for junkies) writes me a scrip for 60 X 30mg XR + 30 X 20mg IR per month. According to the script I am supposed to take a 30 XR when I get up, a 30 XR at around 2, and a 20 IR around 6 to hopefully last me through the evening... which it never does.... because I never sleep... and it's all just never enough anyway. Got to network to keep the supply maintained. But that all went totally by the wayside once PV entered my life, I tossed the adderal tabs in a drawer and didn't give 2 shits about them anymore. In fact there was nothing at all I gave 2 shits about after the PV... except the PV.

I think you should approach a "lower dose" philosophy.

Of course its "not enough"... its in your system for over half the day, your dopaminergic systems are depleted.\

You have to give them time to recharge man.

At max, I'd say amphetamine should be in effect no more than 10 hours out of the day.

You're just begging to throw your circadian rhythm out the window. And once thats gone, your brain will have no sense of pleasure/desire/motivation/direction... it will merely endure in its "low maintenance auto-pilot mode".

 

[Soap MacTavish]

^oh yeah I'm fucked dude, no denying it. I'm a walking experiment. Although over months and years the brain usually repairs this damage if it is treated right.

 

[SpunkySkunk347]

^oh yeah I'm fucked dude, no denying it. I'm a walking experiment. Although over months and years the brain usually repairs this damage if it is treated right.

I think the "damage" isnt always as permanent as it may seem.
Psychosis and other alterations in mental functioning seem to last for days or even up to a week or two, but that doesn't necessarily imply brain damage.

Just take a break. Don't feel like you can do it? Do it anyways. MAKE YOURSELF take a break. Physically force yourself to stop taking it, make yourself WANT to stop taking it. Think about how much more pleasurable it will be after a few days/weeks break.

Drink water. If your piss isn't clear or sort of clear, then you aren't drinking enough water. Drink some powerade too, the new powerade formula has four electrolytes (magnesium, potassium, calcium, and sodium), where as gatorade only has like sodium and potassium. These will replenish your ion channels which is good since amphetamine often causes magnesium ion channels to be depleted.

And after that, you know, eat healthy and get quality sleep, the basic stuff you should know how to do.

Your brain/body will feel fine after a few days, and your mind should feel relatively baseline as well - and also, you should get noticeably better effects from the amphetamine.

 

[<pyridinyl_30>]

Adderall neurotoxicity is real but also highly reversible upon discontinuation of the drug. The hard part is laying off the amphetamine to begin with.

 

[Drumminstoned20]

Atleast for me, amphetamine is like your late 20s, Youll keep getting tougher untill you start coming out of your prime and from there your body just says fuck this. I was at a point where I could sniff up over a gram *appx 1,200mg* in 3-4 days without panic, heart issues, the only negative was a hangover type deal, and yesterday I took 200mg and even after 400mg of seroquel and 2 bayer I was completely positive my heart was failing and my pulse felt like a buzz it was so fast. Great stuff if you do 80-90mg with little tolerance IF your heart and brain are healthy but its not a drug to screw with hardcore. One day, especially during a binge your body may very likely fail to handle it and at less than half that dose can wind up fatal. A couple months ago, 31 30mg ir tabs were gone in under 5 days, and even with seroquel and bayer with a xanax bar at 200mg adderall, I deffinately couldve died. 30 hours later my chest is fluttering and my pulse is barely lower than the peak effect. Dont mess with stimulants dude... Every single one can be lethal. After a few months even at your experience you should be fine. If you dose uppers like that have a few bayers and 2 or 3 xanax bars or a few klonopin. At your rate it might take that much just to survive the trip to the hospital if you cross that line when your body taps out.