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Opioids Adderall making opiods not work due to fast metabolism

Stephy

Stephy

Bluelighter
Joined
Jun 15, 2014
Messages
340
does anybody know if my adderall speeds up the metabolism of my opiods causing them to never get a high enough blood syrum to work? my pain is SO BAD and it actually seems like the morphine makes my pain worse not better, but my pain is infinity worse without the meds also.
 
Stephy said:
does anybody know if my adderall speeds up the metabolism of my opiods causing them to never get a high enough blood syrum to work? my pain is SO BAD and it actually seems like the morphine makes my pain worse not better, but my pain is infinity worse without the meds also.
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well both amphetamine and opioids can act as analgesics however together they can contradict each other sometimes amphetamine can dull feeling of analgesia and can at times make pain worse ime.

but in answer to your question...no metabolisim in the traditional sense is not an issue (there are exeptions) . enzimes however make all the difference, stomach PH, concominant medication, if you have eaten or not these will determine bioavailability and ultimatly C/max, plasma concentration.
for your pain i would highly recommend taking morphine before your pain flairs up. It works much better as a prophylactic agent against pain and then you can top up if you have acute break through pain.
 
Adderall is a stimulant, opioids are depressants.
Basically you are going to be unable to feel opioids from 4-8 hours after adderall depending on the formulation. There is no faster way to burn through a stash of opioids than to combine them with uppers.
 
aftershocknrock said:
well both amphetamine and opioids can act as analgesics however together they can contradict each other sometimes amphetamine can dull feeling of analgesia and can at times make pain worse ime.

but in answer to your question...no metabolisim in the traditional sense is not an issue (there are exeptions) . enzimes however make all the difference, stomach PH, concominant medication, if you have eaten or not these will determine bioavailability and ultimatly C/max, plasma concentration.
for your pain i would highly recommend taking morphine before your pain flairs up. It works much better as a prophylactic agent against pain and then you can top up if you have acute break through pain.
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BUT I CAN NEVER GET ON TOP OF IT!!! The morphine doesn't touch my pain. it doesn't go down A SINGLE PAIN POINT!!! In fact sometimes it seems like it goes up not down!!! flare!!! I'm in a constant never ending flare!!!
 
Is there any medical proven evidence that I can show to my doctor about this? Because I can't get off my Adderall it's what helps me actually get up and move around and be there. Without it I lay around and sleep through my depression for days and weeks and months on end
 
Stephy said:
Is there any medical proven evidence that I can show to my doctor about this? Because I can't get off my Adderall it's what helps me actually get up and move around and be there. Without it I lay around and sleep through my depression for days and weeks and months on end
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im sorry to hear that 😞 , i have chronic pain too so i understand.
it may be time to switch opioids. after some tie an opioid can become less effective and may cause hyperalgesia, a heightened pain response. if you dont mind me asking, are you on er morphine like ms contin or ir like oramorph?
i would talk to my doctor about a dose increase or a switch to a more effective medicine. i will pull up some info you can print to show your doctor, just give me a few hours im really busy atm.
 
aftershocknrock said:
im sorry to hear that 😞 , i have chronic pain too so i understand.
it may be time to switch opioids. after some tie an opioid can become less effective and may cause hyperalgesia, a heightened pain response. if you dont mind me asking, are you on er morphine like ms contin or ir like oramorph?
i would talk to my doctor about a dose increase or a switch to a more effective medicine. i will pull up some info you can print to show your doctor, just give me a few hours im really busy atm.
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Increasing my dosage it's not going to help. I've taken two three or more pills at once and it didn't help or make a difference in fact sometimes it made it worse. I was on the ER now I'm on the IR. I was on the 30 mg extended release plus 15 mg instant release * 4 on both. Now I'm on a fentanyl patch 25 micrograms every 3 days plus the 30 mg IR. I actually lost my package of Fentanyl patches on the 17th and have not been able to find them since I've looked all over the house and my car several times over but still can't find them
 
I highly doubt that is the problem. Either your opiate tolerance is too high or morphine just doesn’t work well for your pain.

But aftershocknrock is correct that stimulants can make the pain much worse when they wear off - I have experienced this, & it’s quite bad - and that can make getting on top of the pain with opiates difficult. I can’t imagine taking stimulants regularly. Even taking them a few times a week is very bad for my pain in the long run.

I feel you on the opiates being too sedating and not being able to function without something to counteract them, but sadly amphetamines are just not a great option for this, at least not frequent use. It’s a real catch 22. Using the lowest possible dose of opiate and taking breaks to keep tolerance down is the best advice I have, speaking from 15 years experience with severe chronic pain.
 
smackatackpunpunpun said:
Adderall is a stimulant, opioids are depressants.
Basically you are going to be unable to feel opioids from 4-8 hours after adderall depending on the formulation. There is no faster way to burn through a stash of opioids than to combine them with uppers.
Click to expand...
This is so true. Addy will outweigh the opiate hands down every damn time unless you are on your stim comedown, only then I get relief or buzz from my oxy, etc.

Don't get me wrong a little "speedball" can work & be fun but is also dangerous. If I ever decide to do this, I usually dose a low amount of amphetamine(5-10mg) and then continue with my opioid dosing.

P.S. -- I DON'T NOR NEVER WILL IV for recreation, so hence for the quotes around speedball because it is not a true speedball, more of a risky cocktail combo if you catch my drift.
 
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Stephy said:
Is there any medical proven evidence that I can show to my doctor about this? Because I can't get off my Adderall it's what helps me actually get up and move around and be there. Without it I lay around and sleep through my depression for days and weeks and months on end
Click to expand...
Using amphetamines when the real issue is depression? Treating a symptom and not the cause?
 
When I used to be on adderall 30mg XR I would take Oxycodone IR… 20 mg to be more specific. It worked great for my pain while on the addy. You should try and get meds switched up, I’ve always heard stories on morphine’s bad qualities for pain when you really need it to work. Oxy IR is much more effective for localized pain in my experienced opinion. Hope this helps.


Taking this combo is very dangerous, I don’t recommend it. But everyone is different!
 
aftershocknrock said:
ho you fucking real yin! keep it up an the next question youl need answered is if your dentist can put back any of the teeth i knocked out your bitch mouth!

You know why i didnt waste my time providing you with sources? because your an entitled moron. Manners maketh the man Stephy old chap, so wind your neck in.
GOOGLE easily has all the info you need but again your a fucking idiot so i suppose i cant blame you for missing that one.

There is not a pill for everything. You will experience pain that is part of life. Amphetamine can heighten pain. opioids will dull pain enough to make life bearable, you are not entitled to a pain free life and no pill will ever let you attain that. If you continue in this manner you will dig yourself into a hole of heavier and heavier opioid use/dependence and pain
Start looking at exercise/socialise with friends family eat well/try yoga or meditation. Trust me the more holistic ways you start looking into to add to your medication the better off you will
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fairnymph said:
I highly doubt that is the problem. Either your opiate tolerance is too high or morphine just doesn’t work well for your pain.

But aftershocknrock is correct that stimulants can make the pain much worse when they wear off - I have experienced this, & it’s quite bad - and that can make getting on top of the pain with opiates difficult. I can’t imagine taking stimulants regularly. Even taking them a few times a week is very bad for my pain in the long run.

I feel you on the opiates being too sedating and not being able to function without something to counteract them, but sadly amphetamines are just not a great option for this, at least not frequent use. It’s a real catch 22. Using the lowest possible dose of opiate and taking breaks to keep tolerance down is the best advice I have, speaking from 15 years
I've tried we didn't ago
experience with severe chronic pain.
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they aren't sedating to me. i just feel a little better and
Jankiez said:
When I used to be on adderall 30mg XR I would take Oxycodone IR… 20 mg to be more specific. It worked great for my pain while on the addy. You should try and get meds switched up, I’ve always heard stories on morphine’s bad qualities for pain when you really need it to work. Oxy IR is much more effective for localized pain in my experienced opinion. Hope this helps.


Taking this combo is very dangerous, I don’t recommend it. But everyone is different!
Click to expand...
I've tried getting this doc to switch up. he just wants to increase my morphine and I've told him it doesn't work well for me. I've told him I've tried all the opiates but he doesn't listen
 
Jankiez said:
When I used to be on adderall 30mg XR I would take Oxycodone IR… 20 mg to be more specific. It worked great for my pain while on the addy. You should try and get meds switched up, I’ve always heard stories on morphine’s bad qualities for pain when you really need it to work. Oxy IR is much more effective for localized pain in my experienced opinion. Hope this helps.


Taking this combo is very dangerous, I don’t recommend it. But everyone is different!
Click to expand...
I agree but only tested ritalin and Concerta basicly the long and short acting methylphenidate
Short 10mg x3 a day
Long 18mg x2 a day
And one thing I noticed is that it always brought my opiod wds come on quicker. So that my exp with the 2. Also I only did this for 2 months
 
I'm trying to keep myself from being an asshole to the asshole but every time I try to erase what I wrote it won't erase what I wrote earlier. I don't mean my metabolism like gaining or losing weight but the metabolism of when the medication has no more Half-Life in my system. Am I making any kind of sense? An hour after my meds I might have a little bit of reduction so that I'm not crying but I'm still in quite a lot of pain
 
Coffeeshroom said:
I agree but only tested ritalin and Concerta basicly the long and short acting methylphenidate
Short 10mg x3 a day
Long 18mg x2 a day
And one thing I noticed is that it always brought my opiod wds come on quicker. So that my exp with the 2. Also I only did this for 2 months
Click to expand...
I'm trying to keep myself from being an asshole to the asshole but every time I try to erase what I wrote it won't erase what I wrote earlier. I don't mean my metabolism like gaining or losing weight but the metabolism of when the medication has no more Half-Life in my system. Am I making any kind of sense? An hour after my meds I might have a little bit of reduction so that I'm not crying but I'm still in quite a lot of pain
 
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