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activation locus coeruleus

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shir

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Joined
Dec 22, 2009
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32
hi
is there anything that can activate the locus coeruleus, in order to make it produce more noradrenaline\norepinephrine?
thanks
 
shir said:
hi
is there anything that can activate the locus coeruleus, in order to make it produce more noradrenaline\norepinephrine?
thanks
Click to expand...

Yes, methylphenidate definitely activates the locus coeruleus, and eventually increases neuronal firing in the prefrontal cortex. Do note that NE/DA increases produce an inverted U shaped relation with respect to improvement in cognitive function in the PFC. Also, activation of alpha-2 receptors will improve working memory, and activation of alpha-1 receptors will decrease working memory. Attention is improved by activating alpha-1 receptors and doesn't really have much relation with alpha-2 receptors.
 
shir said:
hi
is there anything that can activate the locus coeruleus, in order to make it produce more noradrenaline\norepinephrine?
thanks
Click to expand...

If I may ask, what is your purpose in asking this question?

~ vaya
 
Locus coeruleus is activated during withdrawal from alcohol or opiates, and also by taking alpha-2-adrenergic antagonists like yohimbine.

LC overactivation is thought to have a sexually stimulating effect (yohimbine is used as an aphrodisiac and sometimes even spontaneous ejaculations happen during heroin WD).
 
HI everyone and thanks
from what i read, methylphenidate is releasing the NE and DA that you already have. also yohimbine i know it's an noradrenaline a2 antagonist so it make the brain release and NE that i already have. from what i read, the Locus coeruleus is the main part where NE is synthesis so i need to know how can i activate it so it will synthesis much more NE, or maybe i'm in the wrong direction? it's really important for me to know how can i make that brain to synthesis more NE.

for vaya: i'm suffering from a treatment resistant depression and CFS. i defenetly know i have lack of NE, it's a long story. you have any idea how can i enhance the brain to produce more NE (not making it release more NE that i already have, but to make it produce more) ?
 
The only way to increase NE synthesis is to take the monoamine precursor L-DOPA, but that would also cause unpleasant side effects like nausea due to increased dopamine production.

EDIT: I often see posts where people try to draw conclusions about their brain levels of a particular neurotransmitter based on how they subjectively feel... You can't do that... The neurobiology of depression is complicated and it would be a gross oversimplification to say that its caused simply by low levels of 5-HT, NE, etc.
 
polymath said:
The only way to increase NE synthesis is to take the monoamine precursor L-DOPA, but that would also cause unpleasant side effects like nausea due to increased dopamine production.

EDIT: I often see posts where people try to draw conclusions about their brain levels of a particular neurotransmitter based on how they subjectively feel... You can't do that... The neurobiology of depression is complicated and it would be a gross oversimplification to say that its caused simply by low levels of 5-HT, NE, etc.
Click to expand...

i know a lot of people try to do that, but it's really not the case. i made experiments and it's really what i have. l-dopa will make the brain produce more DA, some of the DA will turn into NE. im talking about to make the brain synthesis more NE. NRI do not working on me, actually it works the opposite, enlese i take something that increase the NE quantity like MAOI, then the NRI works good but with all the side effects of the serotonin and DA. any other suggestions?

wikipedia said: The locus coeruleus is the principal site for brain synthesis of norepinephrine (noradrenaline). The locus coeruleus and the areas of the body affected by the norepinephrine it produces are described collectively as the locus coeruleus-noradrenergic system or LC-NA system
so i guess that's got to be a way to stimulate this part
 
wiki said:
The locus coeruleus receives inputs from a number of other brain regions, primarily:

Medial prefrontal cortex, whose connection is constant, excitatory, and increases in strength with raised activity levels in the subject
...
Click to expand...

Or maybe it's close enough to the surface of the skull to be slightly stimulated electrically. I don't know about chemically, but an SNRI should increase NE levels. What do you mean SNRI's had the opposite effect on you? I found reboxetine pretty stimulating after maybe a day or two, and lasted maybe a week before gradually getting used to it. (It was quite a long time ago so I don't remember exact timeframes) What was it, how long did you take it for?
 
Last edited:
shir said:
i know a lot of people try to do that, but it's really not the case. i made experiments and it's really what i have.
Click to expand...

OP, I believe your desire is very sincere, as are your convictions. But you must realize that you are not a diagnostician (please correct me if I am wrong in making that assumption).

Therefore, although it is not outside the realm of possibility that you're suffering from treatment-resistant depression and CFS resultant from insufficient norepinephrine production, I would not feel comfortable advising you to embark upon this path until you seek some professional advice.

So I can get a better idea what you've based your conclusions on, can you explain the nature and methodology of these so-called 'experiments' you performed?

~ vaya
 
when i take NRI it make me so weak, like sucking out my little energy i left and makes me sleep, instead of the exac opposite. the experiment i try is to take NRI while im on MAOI, it worked for and at that time the NRI was working good but as i said with all the side effects and i couldn't take it too long. i am on psychiatrists but they don't know much about how to help me. i would love to know about something that can increase NE production even if it's still on trails or something like that
 
tyrosine is supposed to be an ne as well as da precursor since tyramine is produced by the decarboxylating tyrosine. Tyramine is a non direct adrenergic agonist. How do you know low adrenaline is to blame mate? Tampering with neurotransmitters that dont need it willl do more harm than good
 
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