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acetylcholinesterase inhibitor combined with maoi inhibition

A

Astral-Imagination

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Feb 17, 2005
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The drug Huperzine A
who is a plant derived drug

http://nootropics.com/huperazine-a/

Huperzine A, a nootropic alkaloid isolated from a Chinese herb, has been proposed as one of the most promising agents to treat Alzheimer's disease. Recently, the agent was found to inhibit the N-methyl-D-aspartate (NMDA) receptors in rat cerebral cortex in addition to causing an inhibitory effect on acetylcholinesterase.
Click to expand...

Combined with a reversible MAO-inhibitor (Harmine)

Would this be ok?

I haven't heard about acetylcholine syndrome ;)

Answers appreciated
 
What you call acetylcholine syndrome is the mechanism of most milatary "nerve gases". VX, sarin, soman, tuban, cyclosarin and all those wonderful guys.

Huperzine is about 10,000 times more potent at inhibiting AChE than NMDA receptor currents.

I'd be very careful in combining them, as Huperzine's metabolism may very well be mediated by MAO, and hence MAOIs might elad to dangerously high plasma levels which could be lethal.

I know this is very cautious, but this is an unknown combo, and this is your life we're talking about here.

Start with a 10th your normal dose of huperzine and work up, if that's possible.
 
What exactly is he trying to do? I know that acetylcholine is said to effect memory and that is why it was attempted to be used on alzhemizers deasese. What is the logic of using a maoi inhibiter with the acettycholine inhitbiter for?
 
The logic is when you throw DMT in the above mentioned mix ;)

The aim is to have more memory recall from the actual experience...

Lots of stuff experienced while tripping is forgotten....

The real trick seems to get the experience integrated, this is hard if you cant remember most of it, and mostly this is the case....
 
Most of the beta carbolines are both. It is relatively unknown, but many of them also inhibit acatyl- and butyryl-cholineesterase.
This might be the reason why salviahuasca (salvia and carbolines) works. I’d bet, salvia with moclobemid would not do the same job.
 
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Bilz0r, tuban? I think you mean tabun :)

And you forgot the novichok agents, hm, how neurotropic....=D
 
They seem, from my research, to have a dihaloformaldoxime, where one halogen at the top of the C=N bond is F, and the other either Cl or Br, then with a dialkyl fluorophosphate grup esterified onto the bottom OH, uses some real nasty looking polyhalogen reagents, Cl2If=NOx and such like.

irreversible by oxime treatment, as theres already that aldoxime group sticking off the top like a corrosive chemical boner=D, supposedly, if one survives, there are permanently disabling effects.

I am currently imagining a formaldoxime, fluorinated, chlorinated or fluorinated, with an organofluoroarsenic group at the bottom, say, diethylfluoroarsenate, but how in hell to trap that amide..., and how not to rape the oxime with acids :/
 
tabun, tuban, same dif, I'm just recalling pharmacology I learnt like 4 years ago.
 
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