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Acetylcholine/Choline Excess Symptoms Daily

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xks202

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Aug 10, 2013
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How do I increase acetylcholinesterase activity? I believe based on my symptoms and responses to certain drugs that I have a acetylcholinesterase deficiency. According to studies I've read this can be induced by a virus. The closest I've gotten to feeling better is DXM+Forskolin. But that effect lasts only for say 5 hours if that and afterwards the massive upregulation of acetylcholine activity just brings on every symptom to a worse degree.

I feel hot normally most of the day and night and dizzy. If it is particularly bad I will have body aches and not want to leave bed. Give me an anti-cholinergic drug like amitryptaline and I feel for the most part fine until it wears off (maybe not 100% but 50% better at least).

My mouth is constantly full of saliva it seems. The only dry mouth I ever get is drug induced dry mouth from say marijuana. Benadryl knocks me out and gives me a huge hangover the rest of the next day even at low doses.

I took low dose DXM and forskolin (DXM is a nicotinic receptor antagonist if I'm not mistaken. Forksolin is anti cholinergic by means I think of increasing the cholinesterase enzyme. Forskolin really doesn't do much for me. DXM in just a small cough suppressant dose puts me in a great mood and I generally feel super human on it.

Another symptom is extreme fatigue. I enjoy powerlifting and am quite strong. I am in good shape. It doesn't seem normal that I feel like crap most of the time without anticholinergic drugs. When I take huperzine or aricept the effects are 10 times worse and I get so dizzy even at say 25mcg of huperzine for 2 days that I can't even get up out of bed. And I feel somewhat like this all of the time without taking some form of anti cholinergic drug. Benadryl at the lowest doses knocks me out and does not seem to help at all though.

After the DXM and forskolin wear off I feel even worse as the cholinergic receptors must be upregulating that they block. Again I feel aches through the whole body, dizziness, and fatigue.

I don't know why my body has a tendency to be so supersensitive to acetycholine/choline. Choline supplementation in any form also seems to make it worse at least several hours after. I might take alpha gpc or pyritinol(a choline uptake increaser) and feel better for like an hour but then I just feel worse.

Can anyone help elucidate what is going on in my body and what some possible solutions may be?

I also have a tendency to high blood pressure which really only responds to some anticholinergic agents.

I take no other drugs on a regular basis and do not do drugs recreationally really. I smoked a lot of MJ in high school but that was years ago. I would describe the symptoms as chronic fatigue that resemble organophosphate overdose or something. Yet I have no record of exposure to toxic chems to my knowledge. I've been dealing with these symptoms for around 5 years. It is so bad that I do not even feel good sitting up and writing this and would rather lay down.

I've had all of my hormones checked and multiple medical workups and nothing really shows up.
 
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This is something you should be discussing this with your doc, not the internet. You need lab tests done to test for the sorts of things you want to know. I sort of doubt that your problems are caused by what you think they are, but it's possible.
 
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