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Opioids Acetaminophen

T

Trav777

Greenlighter
Joined
Sep 18, 2012
Messages
29
Location
Southern Cali
Okay, I realize I may just be trippin but I would like some honest feedback based on factual research and knowledge. I also realize that you probably have heard stories or know someone who has done way more than I am about to describe but everyone is different and for every crazy story like there seems to be a story about someone doing way less and having problems.

I have been popping norcos (about 6 a day) and drinking promethazine with codeine (about 4 ounces a day) as well as taking morphine sulfate er 60 mg every other day. I have also been heavily drinking ever other day. This has only been going on for the past 2 weeks because I am off of work and am trying to enjoy it. Today I got a bunch of vicodin 5/500s and popped 6 at once, had a couple beers, and about 3 hours later popped 3 tramadol 50mgs. I would think the only reason I'm feeling sick right now is because I have been dieting and only eating about 1200 calories a day so that alone taxes the body I'm sure.

My question is, am I at risk of liver problems, more specifically liver failure today, right now? I just got home from the gym and I had to stop working out because I felt like I was about to throw up, the region where my liver is was hurting ALOT and I was so dizzy and out of it that I nearly passed out.

I would think my norco use for the past week wouldnt be too bad for the liver because there isnt much acetaminophen in those but do you think the strain on my liver from today has put me in a bad spot or am i just trippin?

Thanks for reading, I appreciate it.
 
Yes you are.... Do a CWE (cold water extract) and get the acetaminophen out. The fact that you are drinking with it also creates a HUGE risk. You are actually not supposed to take acetaminophen after alcohol as it interferes with the digestion and allows toxins to build up or something. Also tramadol is a very odd compound with opiate activity that also has a lot of other activity and could be creating a weird effect.

As far as throwing up and almost passing out it sounds like you are using too much and getting over sedated. Alcohol definitly brings out the sedating effect of opiates and is not a good idea to combine with opiates in general. As far as the liver pain it could be a sign of liver damage, but may go away and fix itself if you have not done too much damage and you stop stressing it out. If it continues to hurt definitely go see a doctor.

Also for reference 1000 mg of acetaminophen is the recommended maximum dose at once while 4000 every 24 hours is the max although IMO that is a lot. Definitely stay safe you only get one body and even though you can transplant it will probably be extremely hard as well as expensive as there are people who did not destroy their own livers with drug abuse that need transplants. Be careful and stay safe!
 
Thank you. Do you know of any foods or things to do to promote liver health and/or cleanse it. The pain has subsided so i'm just taking this as a wake up call and i'm gonna cwe next time. I know you might laugh at this but, I'm not gonna die am i? lol
 
My question is, am I at risk of liver problems, more specifically liver failure today, right now? I just got home from the gym and I had to stop working out because I felt like I was about to throw up, the region where my liver is was hurting ALOT and I was so dizzy and out of it that I nearly passed out.
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See a doctor ASAP. Your body is warning you that you are abusing it.

Eating 1200 calories a day and abusing drugs at the same time is a good way to end up very very ill. 3 grams of APAP in a sitting with alcohol is a lot for a normal human's liver to take with any regularity. 3g of APAP is below the FDA limit so your liver should in theory be fine.

Over abuse of opioids, or withdrawal, can make you feel sickly. But generally it doesn't lead to passing out. The combination of low nutrient intake, alcohol consumption, & fairly heavy APAP usage does not bode well either. In the best case you may just be feeling hungry, and are passing out/feeling shitty from going into ketosis/low blood sugar. But in the worst case your liver is crying for help.

If your liver/midsection still hurts after a halfway decent meal (seriously, that much caloric restriction is not very good for you); start heading to the emergency department or an urgent care facility to get some bloodwork. The etiology of liver failure goes like this.

1. Someone takes a large dose of acetaminophen; too much for their liver to handle.
2. Acetaminophen can cause stomach upset at this stage, vommiting, nausea etc while it is still present in the blood.
3. Liver begins generating NAPQI which eventually cannot get disposed of and starts causing damage.
4. There is a lull of 24-48 hours while your liver destroys itself.
5. As toxins build up in your blood, organs begin to shut down and you die a painful death.

The antidote for acetaminophen posioning is N-acetylcysteine, methionine, or glutathione (10-plus gram quantities). None of these are very palatable and you may vomit it back up if large qtys are ingested orally. But thay are all metabolised to the nutrient that is depleted in your liver by APAP, and restoring it will help your body detoxify the toxic bits.

If you go to a hospital and tell them you are feeling ill from too much Tylenol and alcohol they will help you out. Don't mention the opioids if you don't want to. But please seek attention because your health probably depends on it!

Silymarin from milk thistle can also help, but it is not a direct antidote

Unless you have a seriously good reason not to see a doctor within the next 24 hours, DO IT!
 
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If you are not dead now and the pain subsided probably not. It is definitely a good idea to keep in mind the damage you done and make sure if it flares up again you get it checked.Honestly though people have put themselves through worse.... Such as the 10-20 10/325 norcos a day, which amounts to about 3,000 to 6,000 mg a day. Still that is no reason to relax on how much you use or be lazy when you don't want to CWE.

Edit: Sekio does know more than me... You might want to take his advice unless you REALLY do not think it is necessary, but remember you are talking about your safety and it is either lost time going to do a check up, which is not really a loss as it is always good to check in on your health from time to time, or lose your life because you where not comfortable going into the doctor.

Edit 2: Ya since the pain is coming back in waves I highly suggest going with sekios advice and getting it checked ASAP either by a hospital or else your doctor. I would not recommend waiting until it gets unbearable as that may mean you have caused damage you can not take back.
 
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For sure. I'll probably hit up the local urgent care tomorrow and just get some blood work done to be safe. It would be nice to see what's goin on with me regardless. I'm gonna have to figure out what's up with this cold water extract technique from now on. Thanks for the info and suggestions guys! Gotta love the bluelight community :)
 
Just saying it may be a good idea to get it done ASAP if you do need to get it done unless it is more dangerous for you to get yourself to a UCC without getting yourself rested. If that is the case definitely go as soon as you wake up to get checked.

Edit: Glad to hear your taking the concern seriously and seeking immediate attention for the issue. It is always better to be safe rather than sorry.

Edit 2: Also try not to put yourself through a lot of stress worrying about it as it can make things worse. The idea of harm reduction is to acknowledge the worst case scenario and make sure it is not the case. Hopefully the damage is minimal and will heal itself over time as long as you don't continue to put stress on it.

Edit 3: The guy is right below... Do not drink and take APAP.... It is specifically drinking and than taking the APAP, which usually people do not realize they are doing if they drink at night and take tylonal in the morning for their hangover headache. It is not safe AT ALL to use APAP for I think at least 24 hours after drinking if not longer due to the way alcohol affects the way it is broken down or something. I am no expert I just know it is not safe. Also please update with your results just for info sake so anyone else looking this up can see what the results are even if they are good. Also we all wanna know your safe!
 
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yeh ive felt weird things in my liver region when ive had too many nurofen +

i suggest doing CWE with norcos if the opioid active in norcos is water soluble

try not to get close to the max amount of acetaminophen on a regular basis at all its just not worth the risk

also if your dieting id start by making sure everything you eat is wholefood (not packaged/processed) and cutting down on grains

rather than eating an 1/8th of what most adult males eat a day and feeling lightheaded and weak
 
Glutathione is the limiting factor in the liver's metabolism of acetaminophen. Glutathione is synthesized from cysteine which is obtained from dietary protein. On a restrictive diet, your body is less able to synthesize glutathione, leading to increased oxidative stress, and increased susceptibility to acetaminophen toxicity. Alcohol compounds this. Alcohol and APAP is already extremely inadvisable.

The bottom line: either stop starving yourself or stop eating norcos. You have probably caused enough damage by now. And for the love of Avalokiteshvara, stop drinking with your Tylenol, unless you have a death wish.
 
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I've never done quite a combo like that, but have taken up to 9,000mg of APAP in a day. Buy some Milk Thistle Phytosome (you can mainly only get it off the internet). Also definitely get some N.A.C. at a health food store and Alpha R Lipoic acid and Selenium. This combo saved my life. I had a bad liver from drinking and taking pills. I went from having liver fibrosis to having a mild fatty liver. I was given a year to live when I had the Fibrosis. DON'T DRINK WITH APAP!!!!!!!!!.
 
you've already received your lecture about drinking & tylenol so I'll spare you a repeat of that good advice, but popping 3000 mg of tylenol at once (6 - 5/500's) is an egregious error. 6 norcos at once would have been bad enough, but 6 regular vicodin? WAY too much tylenol in a single serving. Don't try that again.
 
I am confused.... Is this a new thread?.... There was a post like this yesterday from the same person me and I think sekio had both replied to and he claimed he was going to go to the ER.

Edit: http://www.bluelight.ru/vb/threads/646763-Acetaminophen
Duplicated thread

Edit 2: Duplicated thread combined. Great job mod for doing it! Also I pat myself on the back for setting it in motion! :D
 
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My advice is to stop all drugs and alcohol for at least a month and eat whole foods so your liver has time to repair any damage done you have done to it. Also I would be taking Milk Thistle as well.
If you did get a blood works done, get another in a months time after dong what I mentioned above and then you will see if there is damage.
I have been in your situation before so I know what it can be like.
This is the thread I started with my concern : http://www.bluelight.ru/vb/threads/612996-Help-with-my-(drinking-problem)-liver

I hope you have realised the problem before there is any serious damage, Good Luck.
 
bayhead415 said:
I am confused.... Is this a new thread?.... There was a post like this yesterday from the same person me and I think sekio had both replied to and he claimed he was going to go to the ER.

Edit: http://www.bluelight.ru/vb/threads/646763-Acetaminophen
Duplicated thread

Edit 2: Duplicated thread combined. Great job mod for doing it! Also I pat myself on the back for setting it in motion! :D
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You should report it next time, much more helpful and staff can get to it faster. But yeah I merged two identical threads, they both had decent information so I didn't want to just delete one, hence the merge.

Thanks for trying to bring it to my attention though. :)
 
I did report it... W.E guess you caught it as I reported it....

Edit: I try to be thorough and make sure it is noticed :D
 
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Wow, this is incredibly dangerous. Acetaminophen is dangerous enough to the liver (I believe toxic doses have been listed at 4000-8000 mgs), but drinking on top of that is pure hell for your liver.

If you have any kind of health insurance to to the doctor and have a liver enzyme test to see how your liver is doing. This is the best possible thing you can do right now.
 
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