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Acetaminophen as cannabinoid pro-drug

Coolio

Coolio

Greenlighter
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Feb 29, 2004
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Has anyone else already read about the fact that acetaminophen's method of activity has been discovered, and that it's been found to be a pro-drug for the cannabinoid AM404? This came as quite a shock to me...
 
yea i read a small snippet about this. don't remember much about what was mentioned tho.
got a linky-poos?
 
It means that acetaminophen is converted into a cannabinoid in our bodies.
 
yeah as I understand it p-aminophenol forms an amide with arachidonic acid, forming a cannabinoid agonist ligand.
Administration of a cannabinoid antagonist blocks the analgesic effects of paracetamol.
 
^ well, that's true.

APAP won't get you high. the chemistry is interesting, though.
 
well if it gets converted into a cannibinoid in our brains why dont we feel anything?
 
Because cannabinoids surely don't all make you feel anything. Like how not all opiates do (loperaminde comes to mind). Our brains have natural cannabinoids and receptors for them. Some of them make you feel certain ways and some probably serve other functions.
 
first that this was acting as a pro-drug is somewhat old news

anyway, AM404 is an "ARI" -- Anandamide Reuptake Inhibitor

anandamide while known as a CB1 AGONIST also is known to not express THC-like effect in regards to the "high" they can foster, but is know to have an analgesic effect
 
Let me reiterate that acetaminophen is one of the—pardon the term—'dirtiest' drugs

I advice discussion of APAP cease and desist immediately
 
Oh come now, I for one find it highly amusing that one of [largely-antidrug-alarmist]society's most widely used drugs is a cannabinoid agonist. What would all the soccer-moms think if they discovered their precious children were taking CANNABINOID DRUGS!?
 
um, hopefully maybe a little insight into a stigmatized yet highly important and beneficial system of human physiology

though unfortunately as stated while not without some usefulness acutely it is a dirty hepatotoxic drug...chronic use is a lot more dangerous than cannabis
 
There's much better drugs for its current prescription; I'm saying that it's a poor status quo for analgesia
 
I think paracetamol (as we call it) is a little psychoactive actually... makes me feel serene, somehow. Less 'talk' in my head and more focus. But yeah it's not a healthy drug, at all! When i remember my ignorant days of beign a teen and eating half a packet of them cos I'd heard you can get really high - jeez!

Hm, if it's a cannabinoid indeed, won't it compete with THC for receptor binding when one has taken it? So that one will get less stoned from a joint while udner the influence of paracetamol?
 
^Good question Maybe there are different cannabinoid receptor sub-types and they act on different ones. Fascinating topic.
 
there are at least two cannabinoid receptor subtypes, they've been known about for a long time. Subtype subtypes? I don't think any have been found, or that there's any evidence for that. Not positive, but for sure, there's at least a CB1 and a CB2
 
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