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Abuse-Proofing a pill? What would you do?

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tenshu2k

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I was talking to a friend about this topic, and there always seems to be a way to circumvent anti-abuse techniques put in place.

What would be the best way to abuse-proof a drug- either to prevent it from being snorted/dissolved or breaking it down into more use/abusable substances.

Gelling agents seem to be an interesting option.
 
I've always thought that they should unschedule a number of substances that aren't to bad for you in moderation such as mdma,lsd,shrooms etc and simply have a system for them controlled by the government where they can track how much you've purchased and have there be only a limited amount that you can purchase per year, and if they were worried about the substances being sold on the black market by people that didn't use maybe at the place where you'd purchase them also have a good area for tripping or enjoying your buzz where you would have to ingest it in front of them and maybe stay in said area for safety precautions and what not, kinda like a bar but for drugs
 
Would capsaicin cause digestive issues for those sensitive to it though? Perhaps a capsaicin analogue which was more effectively destroyed in the stomach to prevent certain side effects.

I presume that is why pharmaceutical companies say they have not implemented this so far? Obviously abusable medications are in their best interests as they drive a huge market.
Does capsaicin cause burning with IV administration? Because if not then it would probably drive people to IV use much faster.
 
Interweave the pill with an antagonist(at whatever receptors the drug is supposed to work on), the antagonist should be compounded/encapsulated in such a way that it doesn't dissolve under any normal conditions, but is released if the pill is broken or crushed. And of course combine this with gelling agents(that way you couldn't just dissolve the whole pill in water and filter off the undissolved antagonist).
 
any "abuse proof" mechanism that releases the drug into your body will neccesarily be defeatable, given enough time... and any 100% "abuse proof" med will by neccesity not release any narcotics. ;)

the oxy-neo style indestructible pills do a pretty good job of making oxycodone unextractable to the lay-man. gelling agents are 2nd place but more easily defeated.

given that capsacin is very lipophilic whereas most drug salts are not, removing it would be trivially easy to someone equipped with solvents.
 
Gelling agent would make it more difficult to snort or inject. Though you could probably extract it pretty easy with some solvents/reagents.

I've seen some polymer coating technology thats getting to a point where it will be difficult to crush a tablet.
 
Though it would have to be something that ultimately breaks down in your gi tract at some point. And there are acid/base extraction processes that can defeat even ion-exchange matrices (or I'm a bit foggy on the details...I want to say an extraction in a basic solution and a non-polar wash). So yeah, if the user isn't lazy, the project's ultimately impossible.

ebola
 
Gelling agents. Capsaicin. Denatonium.

On the Flynnal Sodium, apparently they were going to add Denatonium to the flynalbarbital sodium to make it so bitter that nobody could realistically use it for suicide as they would literally projectile vomit as soon as they tried to drink it. But it was bitter enough without having to add the Denatonium.

But sure they could add these to strong opiates, toxic barbiturates like pentobarbital or secobarbital, to discourage suicide or IV abuse, they could even add these to benzos (even if they're non-lethal) because that way someone would know they were laced.
 
i really don't think this is legally possible, because they'd have to actually poison people. you can always break something down if you're smart enough and it's like the old thing my parents used to do to my thumb to try to get me to stop sucking it. painting jalepeno pepper shit on it so i wouldn't like the taste. but it turns out i developed a knack for the taste and didn't give a fuck. it's really sick the things they could do to literally reject a drug out of the system because whenever a drug fucking exists on the market for any reason (they do keep coke in hospitals for very bad nose bleeds, etc) it's there for a REASON and therefore when you take it for the reason given you would just reject it and not be abl eto benefit from the actual usage. ie obvs etc etc once again there is no safe way to prevent drug abuse. they did a really nice job pretending tussin actually helps your cough by slowing drugging you but making it nasty fucking tasting so no one "in their right mind" would drink a ton of it, then they made those tussin gel caps so, i mean. haha. whatever. when i was in high school and just pulling my psychs strings because i didn't know what the fuck was wrong with me and just getting whatever i wanted, i once told him i couldn't "focus." so well he gave me adderall XR and just like the xanax XR i chewed the shit out of them even though it was sick as shit.
 
if the pill is aimed at giving a long lasting oral effect, but abused by injection, i'd bind the active ingredient to a polymer matrix with bonds that are cleaved by digestive enzymes. of course not 100% abuse proof, but that surely requires some chemistry to circumvent.
 
Yup, vyvanse is a great example of such a modification and seems to have been quite effective.
 
I would rather make it safer for people using alternative delivery methods to get high, especially when they start injecting pills (at least make them gelcaps with the actual substance dissolved inside so if some one wants to inject it, he can just draw the decently sterile contents out and inject that).
 
curiosity said:
I've always thought that they should unschedule a number of substances that aren't to bad for you in moderation such as mdma,lsd,shrooms etc and simply have a system for them controlled by the government where they can track how much you've purchased and have there be only a limited amount that you can purchase per year, and if they were worried about the substances being sold on the black market by people that didn't use maybe at the place where you'd purchase them also have a good area for tripping or enjoying your buzz where you would have to ingest it in front of them and maybe stay in said area for safety precautions and what not, kinda like a bar but for drugs
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Unfortunately that would be way too expensive for any government to cost. I would prefer the government investing in other things such as health or education. Even if I find your idea appealing, it's sort of a luxury and there are more important things a government should pay for.

This would only work if these drugs would have very high taxes and the government got enough money from it to cost the "tripping rooms". Even in that case I would still prefer the government investing that extra money in health and education.

Sorry for the off topic (;
 
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How about some virus/bacteria that gets broken down by the GI tract/ stomach acid but very virulent/infective when applied to mucous membranes/blood. shit could even be aids in microcapsules. too evil?!
 
Burn it up said:
Unfortunately that would be way too expensive for any government to cost. I would prefer the government investing in other things such as health or education. Even if I find your idea appealing, it's sort of a luxury and there are more important things a government should pay for.

This would only work if these drugs would have very high taxes and the government got enough money from it to cost the "tripping rooms". Even in that case I would still prefer the government investing that extra money in health and education.

Sorry for the off topic (;
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This is true sadly, but here in quebec I find we have a pretty decent healthcare system compared to a lot of other places, education could use a little work though.
 
Whatever formula the oxy OP uses seems to stand up even against the most desperate junkie

Also, Tylenol is always gonna destroy a drugs ability to be IV'd
 
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