Absorbtion of Methylone Affected by Calicum?

[fict]

The subject swallowed 166mg methylone hcl. Within a minute, subject realizes that he has not yet taken a multivitamin today, and so he decides to swallow one of those as well. As it turns out, this particular multivitamin contains about 162mg calcium carbonate/dicalcium phosphate. Subject thinks nothing of this fact, and, within about 10 minutes, feels a very slight, but unmistakable methylone alert. 30 minutes after taking the methylone, subject is off baseline, reports slight stimulation and slight euphoria. After 90 minutes, the effects have not substantially increased. Subject says that the effects of the methylone are definitely present, but the intensity is comparable to no more than 40-50 mg methylone, which he had consumed several months prior. He had taken d-amphetamine sulfate (50 mg) earlier in the day, and had been out drinking the previous night. The subject was pretty tired when he consumed the methylone, due to having attended a local music conference & numerous concerts the previous two days.

I've read a few excerpts here and there which suggest that basifying one's stomach contents will inhibit the absorbtion of MDMA. I've read a few that suggest basifying increases absorbtion. It is well known that consuming baking soda or other basic substances (tums, rolaids) increases and/or alters the effects of d-amphetamine and opiates. However, I have not found any information regarding stomach acidity and methylone, nor have I found anything conclusive about how MDMA is affected by stomach acidity.

Input would be appreciated.

 

[BilZ0r]

I would have thought the amphetamine would have had a bigger effect than calcium. It sounds like you read that big MDMA-base thread that I took part in about a week ago. That calcium wouldn't have had a big effect on pH byitself, so the chelation theory raises its head again... *shrug*

 

[fict]

I have not actually read that thread, but I'll go take a gander in a few moments.

I considered the possibility of cross-tolerance between amphetamine and methylone, but the subject has, on prior occasions, used amphetamine within 24, 12, and 6 hours before consuming methylone. The methylone dosages in those prior experiments was always relatively low, usually hovering around 125 mg. All experiments presented a level of intensity which far exceeded this most recent experiment.

It seems to me that a portion of the methylone may have been (maybe?) converted to a freebase and was not readily absorbed...

*shrugs*

 

[BilZ0r]

freebases are more quickly absorbed than salts, so thats not it. amphetamine(s) and methylone should be cross tolerant to a degree, but not much is know about methylone (well at least I don't know much about it) so further help is hard.

Where the hell does a drug like that come from? Shouldn't someone do something about the ketone group?

 

[santadog]

I’ve done methylone lots of times. I also take a daily multivitamin (centrum) and have noticed no adverse effects. Maybe there is something else in this particular multivitamin besides calcium that is having an effect? Maybe it’s just tolerance to methylone itself? The effects of a 160mg dose can definitely weaken with experience. My best guess is slight cross-tolerance with amphetamine but who knows. IMO 190 – 250mg methylone is ideal anyway, much less just doesn’t seem worth the cost (especially 40-50mg – can you even feel that?)

 

[*TM-321*]

I dont think the calcium had much of an effect. I really dont think the amphetamine could have affected it that much either. I would say that first off ~150mg is a bit of a weak dose to begin with and probably was a contributing factor. I think the most relevant thing you mentioned was the lack of sleep and the fatigue. Lack of sleep can have a HUGE effect on brain chemistry. Also methylone is not near as stimulative in its effects as MDMA. Maybe he was looking for something in methylone that just isnt there. All in all I would pin it on lack of sleep.

 

[Marauder]

Just how much amphetamine did you take? Perhaps it released most of the dopamine that would otherwise have contributed to greater euphoria on methylone?

 

[DwayneHoover]

50mg amphetamine is alot. One 20mg Adderall (mixed amphetamine and dexedine salts) is pretty potent, and kinda time released... 2 of them at 40mg gives me euphoric rushes and scalp tingles... 50 would be pretty damn strong).

Not cross-tolerance, per-se, but:

I'm guessing that Amp caused a massive and rapid release of most of the extra stores of neurotransmitters stored in your neuronal vessicles. Essentially depleting them, or leaving them on LOW. So there wasnt much left to release when then M1 tried to to release them.

SO far as the acifity/basification question... YES, food triggers release of lots of natural stomach acid... taking M1 within an hour or two of food thus reduces its effects, as does drinking alot of acidic citrus juice.

It's not a phenethylamine, but a phenethylamine analogue, so some similar chemistry seems to be at play, from my experiments... being bk-MDMA (and of course MDMA is a phen.)

YES, taking a teaspoon of pure baking soda (yuck, and it gives you the runs in short order, but its the most effective), or like 10 big chewable TUMS about 10-15 minutes prior to M1 (no more, no less... timing is everything) is enough to temporarily and slightly basify an empty stomach (which is not that acidic in fact until food hits it and it then releases the acids... theyre energy consuming to make, so it saves them till needed).. and YES! it DOES increase the potency of M1... I've done that several times, and experimented with timing and amounts of the Baking Soda /TUMS. I was able to do SLIGHTLY less M1 than my usually needed threshold dosage (175mg) down to maybe 140mg and still got the same effect.

And it made 120mg M1 workable, if I combined it a little bit of some stim,I used 1,3-DMAA (Geranamine... 50-70mg... normally on its own I would use 100-120mg, but with the M1 that's too much), plus some caffeine, like an energy drink of some kind.... (DMAA on its own is feelable but not quite "there"... it seems to want some caffeine to kick it into activity.), followed 20-30 minutes later by the baking soda/tums, followed 10-15 minutes later by the 120mg M1.

Well that's a little lecture summarizing my mad scientist experiments.

 

[windowpaine]

As a purely anecdotal statement, the least intense time I ever had on methylone was when I took it after eating a whole shitload of ice cream. I've noticed that if I've eaten anything in general within about 2 hours prior to dosing it cuts into the euphoria but the ice cream experience was weak sauce even by comparison to eating pretty heavily.

I don't have any opinions about whether it was the calcium or the milk or what. Just something I noticed.