Misc Absolutely TERRIFYING TRAZODONE EXPERIENCE seratonin syndrome ??

[GoodTimesRoll]

So I get prescribed a 30-count of 50mg Trazodones each month. One night a few weeks ago, about to be getting on the tail end of a sober all-nighter (I play a lot of video games), its about 4 in the morning. I decide to really get some sleep, so I took 5 of my Trazzy 50s all at 0 time from each other along with 2 melatonin pills, not thinking that Trazodone is actually a serotonin inhibitor... While waiting for the meds to kick in I decide to take the dog out for a walk around the neighborhood, and this is where things start to escalate... I start to feel not too great but not too bad as the trazodone starts to kick in, my mindstate just starts to wonder aimlessly and innocently, for now... About an hour later, while I'm laying in bed quite restlessly to my surprise, I bolt up all of a sudden and immediately it hits me all at once and I realize, "oh shit, here we go, I'm in too deep"... I start to freak out in a wild, paranoid panic. Instantly thoughts of me dying come into play, thinking im not gonna wake up if I fall asleep. If I moved the slightest bit in any way my heart beat would shoot through the roof. And I thought if I didn't move a single muscle and breathed as slow as I could that it would go down, but it didn't.. Eventually I did what most do in an overwhelming freak-out: I pulled the hatch. I tried to puke as much as I could to reduce my panic attack, which it would for about 30 seconds before I stood up and it would come right back. This went on for a couple more hours into the early morning before I finally threw up for the last time and calmed down just barely enough to pass out probably around 7 am. I woke up around noon-time in just the mild trazodone daze, and I was completely fine. The lazy/tiredness lasted the rest of the day, but other than that I was fine. At the time of this I wasn't aware of serotonin syndrome, but recently reading up on similar experiences like this, I sort of put the pieces together after the fact. But im still not certain that was it, so any suggestions?

 

[tweex]

Plausible. Could also be an adverse reaction to the metabolite mCPP.

Regardless, 250mg is a bit high of a dose for sleep. I generally use 100mg.

 

[Lady Codone]

I once got very sick (puking, which I never do) off trazodone + a few other drugs/supplements that I can't recall. Sounds like you took too much. I don't think traz is something benign that acquires an infinite ceiling of tolerance the way some other drugs do.

 

[bennyZA]

Is it possible that it was a panic attack brought on by you thinking about taking such a high dose? I've seen this quite a few times. Someone takes too much of something gets nervous and then has a panic attack. Then they assume it was the drugs. Or it could have just been a panic attack that had nothing to do with trazodone.

What you describe sounds exactly like a panic attack, to a t. It's terrifying and has all these horrible physical symptoms but then it's over with no lasting problems.

 

[sekio]

It's very unlikely trazodone would cause "serotonin syndrome" all on its own - more likely you had a panic attack.

 

[Ksa]

I don't think you can physically panic or have a panic attack while under serotonin syndrome. It completely inhibits panic responses. You can definitly realize that the situation is very serious, dial 911 or other help, but you won't be in a panic. Even if you know you'll die, you just...accept your fate. It feels like your brain is buzzing really loud and you can feel a strong odour of whatever you smell around you.

 

[Bagseed]

this rather sound like an intense panic attack. go to a doctor or therapist, if these start to occur more often.

I often have panic attacks in which I feel like I'm gonna faint. It's not unusual that you feel like your physical body is in danger while having a panic attack, yet nothing happens. I never fainted while having an attack...

 

[bennyZA]

When I had my first panic attack, I couldn't walk, had trouble breathing, etc. I got so scared I went to the hospital, but after some Ativan I was fine. I think you should go see someone about this and hopefully they can give you some ativan. Remember, don't abuse it cause when you have another panic attack you will be PISSED if you ate them all.

 

[XThexXTank]

Yeah i getta scrip of these every month for sleep an i never had that happen to me. Idk if its a good idea to mix it with melatonin. Never even knew or heard of trazodone doin that to someone. Go to the doc man.

 

[DubNaut]

i had a script for these years ago, after 1 50mg attempt.
I was absolutely suicidally depressed the next couple of days, never again did i try the chem.

 

[88ed3]

Excess SRA promotes SS.Respect your Seretonin...don't fuck up your life and live with amnesia or Parkisons Disease.

 

[Tryptamite]

150mg is the max I'd take. Horrible med with horrible metabolite. Sometimes though you need to sleep and have absolutely nothing else on hand.

 

[RTrain]

Sounds very much like the panic attack I had last week from thinking I did too much heroin. And other times when the same thing has happened. I get a spaced out dissociative like feeling and then it hits me all of a sudden. I am panic stricken and mine are relatively rare, but they typically last the whole day and leave me a bit shook into the next day. I never make myself throw up, though, did you do that in case there was still Trazadone in your stomach?

 

[Moredopamine]

Sounds like a simple ol' case of freaking the fuck out because you "think" you did too much. Maybe next time you can lower the dose and/or forgo the melatonin.

 

[GoodTimesRoll]

Well to be honest I cant completely remember what went on in my mind the minutes before it hit me. Ive had problems like this with other drugs before, and ive talked to some close friends and they say a lot of the same things, how I just sike myself out for it by thinking it. And quite recently these 2 to 3 hour panic sessions have been happening with me being completely sober as well actually. I may have the feeling that all of these episodes might be residual effects from my Dextromethorphan phase I went through just a couple months ago, and its all coming back to haunt me.....

 

[GoodTimesRoll]

And after this incident I even tried to start taking my Trazodone normaly again, but even 1 to 2 of my 50mg pills would trigger it, though being a bit more mild and a little easier to control. Now it makes me freaked just to look at my script bottle, im going to tell my doc that its not working and I need off asap

 

[GoodTimesRoll]

tweex: metabolite mCPP?

 

[James947]

I had the exact same experience although I had drank a six pack. I am also on Lamictal and aderall. I took two 30 mg's of trazadone. About a half hour later I started to not feel so good. I was really out of it and then went into complete panic and bad trip mode. I collapsed on my floor and hit my head on something. I could not escape the vortex of terror. Every time I got some control of my breathing I would try to stand up. Then it would instantly start up again. Somehow I was finally able to convince myself I was ok and I wasn't going to die and I came out of it. I woke up this morning to a huge gash in my head and blood everywhere.

 

[MagickalKat777]

I hate to tell you GoodTimesRoll but it sounds like you are starting to move into the panic disorder anxiety spectrum.

The reason that trazodone can trigger such a powerful panic reaction at high doses is most likely because of mCPP being its metabolite. It is probably the dirtiest piperazine that has ever been used as "ecstasy"

Behavioural effects of rapid intravenous administration of meta-chlorophenylpiperazine in patients with panic disorder and controls.

van der Wee NJ, Fiselier J, van Megen HJ, Westenberg HG.

Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands. [email protected]

Oral and intravenous challenge paradigms with the direct 5-HT agonist meta-chlorophenylpiperazine (m-CPP) in panic disorder (PD) have shown only moderate sensitivity or selectivity of the panicogenic effects in PD. However, the results of a study examining the effects of rapid intravenous administration of 0.1 mg/kg of m-CPP in healthy volunteers suggested that this approach may be a more selective and sensitive panicogenic paradigm in PD. We therefore compared the behavioural, neuroendocrine and physiological effects of rapid intravenous administration of 0.1 mg/kg of m-CPP in 10 patients with PD and 10 healthy controls. Panic attacks were significantly more provoked in patients with PD (90%) compared to healthy controls (0%). Effects on the behavioural, but not on the neuroendocrine and physiological parameters, were significantly greater in patients. Our data suggests that the behavioural effects of rapid intravenous administration of 0.1 mg/kg of m-CPP in patients with PD indeed show a unique combination of high sensitivity and selectivity.

http://www.drugs-forum.com/forum/showpost.php?p=110734&postcount=5

A discriminative stimulus produced by 1-(3-chlorophenyl)-piperazine (mCPP) as a putative animal model of anxiety.

Wallis CJ, Lal H.

Department of Pharmacology, University of North Texas Health Science Center, Fort Worth, USA.

1. This study compares behavioral responses to serotonergic (5HT) agonists and pentylenetetrazol (PTZ) in two behavioral paradigms used as animal models of anxiety. PTZ and mCPP were compared for behavioral effects in elevated plus-maze and interoceptive discriminative stimuli they produce. 2. PTZ is a known anxiogenic drug. The discriminative stimuli of mCPP were selected for comparison because this drug produces "anxiety" in human subjects and "anxiety-like" behaviors in rats, and is a potent agonist at 5HT1B/2C receptors and a partial agonist at 5HT2A receptors. 3. In rats trained to discriminate mCPP (1.4 mg/kg, training dose) from saline, PTZ substituted for the mCPP suggesting the "anxiety-like" properties of the mCPP stimulus. The mCPP stimulus was blocked in a dose-related manner by methysergide, a 5HT2A/2C antagonist but not by the anxiolytic diazepam. TFMPP (a 5HT agonist) and DOI (a 5HT2A/2C agonist) substituted for mCPP, but 1-NP (a 5HT1 agonist and 5HT2C/2A antagonist) did not. 4. In animals trained to discriminate PTZ (16 mg/kg) from saline, mCPP and DOI substituted for PTZ, while TFMPP and 1-NP do not. 5. In the elevated plus maze, time spent on the open arms was reduced by mCPP, DOI and PTZ but there was no significant dose effect of TFMPP, or 1-NP. 6. Methysergide blocked the "anxiety-like" behavior in the EPM. 7. These data suggest that the discriminative stimuli produced by mCPP are based upon its selective actions on 5HT receptors and their use in behavioral pharmacology may offer another tool in studying pharmacology of 5HT based anxiogenic and anxiolytic drugs.

http://www.drugs-forum.com/forum/showpost.php?p=110736&postcount=6

As you can see, mCPP is actually known to trigger panic attacks.

This is one reason why less is more with trazodone. 250mg is definitely enough to elicit a panic reaction from the mCPP metabolite. Its quite a potent bastard. I can't take more than 100mg of trazodone at a time.