abilify(alpipirazole) & methamphetamine

[DJHENRU]

What does Aripiprazole do for M-amp? I have confused about its effect post dose of mamp.

 

[DJHENRU]

have confusion* it just potentiates?

 

[AlphaMethylPhenyl]

It attenuates the reward while probably ( I think) protecting against neurotoxicity and increasing want to use and decreasing amphetamine side effects. I take amphetamine and aripiprazole. Maybe the advanced mods have a better/superior answer. This is tentative.

http://www.nature.com/npp/journal/v30/n11/full/1300803a.html

 

[DJHENRU]

seemed like less reward more stimulating and lamely antibipolar. Just increased urge to dose, and maybe the stimulation was from benzo withdrawal. thanks Its hard to undersstand some of the other studies that tally different psychological scores into 1 number and then also make the user look at video of paraphernalia, which is retarded to me because I dont use.

 

[AlphaMethylPhenyl]

I'd like to hear other opinions on this. We should have it moved to Add.

 

[BlueHues]

^Yeah, this is probably an ADD question....Abilify is weird shit....Strongly dislike it myself....

 

[Znegative]

Ok your wish is my command

 

[DJHENRU]

I dont really want two add threads, the current subjects therein need futher working out imo

 

[ebola?]

Sporadic anecdotes suggest a variety of different responses to the combination. Albilify's mechanisms are rather complicated: albilify has a range of activities at different DA receptor subtypes, most of them partially agonistic, so response to albilify (and the particular interaction between albilify and stimulants) varies a great deal, depending on the particular set of dopamine receptors in the subject's brain.

ebola

 

[BlueHues]

^So basically, Abilify is some weird shit?! That's exactly what I thought!

 

[DJHENRU]

hits more than d2 including like hystamine, so its like anti-presleepy phase of delirium? definitely knew what direction where what cardinally. Mostly did not really seem to notice the extreme half life.

 

[AlphaMethylPhenyl]

Sporadic anecdotes suggest a variety of different responses to the combination. Albilify's mechanisms are rather complicated: albilify has a range of activities at different DA receptor subtypes, most of them partially agonistic, so response to albilify (and the particular interaction between albilify and stimulants) varies a great deal, depending on the particular set of dopamine receptors in the subject's brain.

ebola

I thought it only had action at D2 (partial agonist). Do you have sources for the other D effects? Can you generalize a conclusion as to the combination, in regards to toxicity, attenuation, potentiation, or the like?

^Yeah its half-life is over seventy hours. Still, I definitely felt it when I didn't have it for a day.

 

[ebola?]

Look at the binding affinities summarized here

Abilify is a shotgun of sorts...

ebola

 

[pizzystrizzy]

I don't totally trust that list, as it conflicts with some studies I've seen, e.g., http://www.biomedsearch.com/nih/Aripiprazole-novel-atypical-antipsychotic-drug/12784105.html

 

[AlphaMethylPhenyl]

^Awesome source, thank you. I was initially under the impression that aripiprazole displayed antagonist activity at all but 5-HT1a and D2.

And not to hijack the thread, but is aripiprazole thought to be neurotoxic after long-term use a la the other anti-psychotics? And would use of a stimulant mitigate any toxicity? I feel like there haven't been many responses which directly address the issue.

Maybe you can clarify these sporadic anecdotes.

Here's a bunch of data on aripiprazole: http://www.ema.europa.eu/docs/en_GB...tific_Discussion/human/000471/WC500020164.pdf