It works at one week, its better though at two weeks. I trip monthly and you can tell the difference from a monthly trip vs a two week interval. The tryptamine and LSD cross tolerance is probably a bit over stated, same drug tolerance IME, shrooms or LSD alone is worse for tolerance. From some drugs, like 2-cb, i could take it two or three days before or after LSD and its almost as strong. Taking any psychedelic too much too often can give you perma tolerance. I recommend moderation just for that reason