A (somewhat) Complete List of Novel Antidepressants Undergoing Trials

[Bluejay1]

I'm just not aware of any KOR antagonists in the pipeline, maybe its about time I read that list I got to see if there are any in the exploratory phase. With the recent interest in Salvinorins and dynorphins I wouldn't be surprised to see something in the pipeline. I tend not to give new molecules much interest until Phase II, however. What is the point of salivating over a chemical that only has a 5% chance of coming to the market.. Unless of course you have your own private lab to synth or order these research chems.

Awhile back I think there were KOR drugs for analgesia, but if I'm remembering correctly they came with negative side effects like hallucination.

I'd love to see pharma-research show more interest in sleep-mediated ADs. It almost seems as if sleep is entirely ignored and only the wakeful process is focused on.

Drugs like almorexant, agomelatine and perhaps deltaran. Now that's what I'd like to see more of. To hell with methylphenidate, eugeroics, and amphetamines like lisdex.

 

[seep]

Why no mention of opioid kappa antagonists on this list?

Im probably going out on a limb here, but I tend to believe that the instant "mood lift" that bupe provides (as opposed to the typical opioid euphoria which is absent in bupe), is more due to its antagonism at kappa then its agonist at mu.
anyone else agree?-DG

dg, there's at least 1 study, on buprenorphine and suicidality. Clinicatrials.gov returns about 220 results for the drug. You'll find similar results for ketamine, modafinil and the stims. I think the list I linked to focuses only on new drugs or new formulations, and it's incomplete. I'm sure a number of existing meds from various disciplines are vying for approval for the catch all "treatment resistant major depression" and various permutations of anxiety, and these are little more than attempts to get permission to advertise the product as a remedy for such and such. Doctors nevertheless (at least in Florida) can, for instance, prescribe amphetamine and methadone for depression; it's a bitch (I know, I read your reply to this point already in another post) it's a bitch to get major-chain pharmacies to fill these scripts though. A lot of docs just stock the contentious meds at their clinics. Some others just send their patients to a particular independent pharmacy. I've found that the local doctors who were educated in Europe are more open to prescribing a scheduled drug in an off-label manner.

Bluejay, that article, if you have it and since you're offering, would be nice to have (understatement). Are you allowed to at least read PMs? Oh and almorexant is on the list among the sleep meds (along with oh look esmirtazipine just noticed that) which means that once it makes it to market it'll be fair game to push it to psychiatrists cuz insomnia, anergia and anhedonia are almost ubiquitously documented as symptoms of MDD.

Edit: Yale's currently recruiting for a salvinorin A study; one of the inclusion criteria is "previous exposure" to it.

 

[Bluejay1]

Seep, I am so looking forward to Almorexant. I think Ill cry if FDA rejects it.

Concerning the 48p pipeline.. I cant post it, Bluelight wont let me.

I tried to get my posts up to 50 but then some mods get pissed at me for spamming (I was posting hello in forums to introduce myself, apparently this is not allowed). I get responses from mods as if I was cursing at people and slinging names.

I can only post things under 100bytes I think and that PDF is well over.. I tried posting it believe me. A friend from another forum has good access to papers so she was nice enough to get it for me.

I would copy/paste but I don't think that'd be allowable concerning copyright laws.

I will check to see if you got email address and mail to you if you'd like Seep.

I can only read PMs I cant reply. Really blows. Plus I get extremely bad vibes from mods here - I won't be surprised if one comes along to ban me out of spite. Amazing how a little bit of power given to small minded people can turn the average nice person into a monster

I can't rush along my bluelight status bc I'll prob be banned if I try, that is if Im not already going to be banned.

 

[Bluejay1]

Seep, here is a pseudo-list.

http://www.nootropics.com/refs/

Only posted it bc it has a relatively long list of items in the spirit of comprehensiveness...

Just add the 3 lists together: NT.net, Herlling2009, nootropics.com's list and you have about 65% of what is in the pipeline or in private labs, of course there's always more out there.. if you can find a list of Russian drugs it would be great to add..

All is needed is a single website to post such a list on and you have an amibitious but worthwhile project on hand.

Neurotransmitter.net has a decent streamlined forum for a list, however, it is a bit confined and not all-encompassing as such a list could be.

List could include in categories, meds for:
ADD/ADHD
Depression
Sleep
Alzheimer's
Nootropics
Parkinson's
Multiple sclerosis
etc, etc

with some kind of disclaimer at the top

 

[Bluejay1]

oh yea..
Bipolar
Schizophrenia
Mild cognitive impairment
Ataxia's: TRH analogues like taltirelin
Methylene blue...
The list alone could span at least 200+pp

Would also suggest a category for HERBALS, being that an herbal by itself is unlikely to cure any of these neurological disorders and would prob be best if herbals were lumped all together in one section so they don't get confused with the real drugs

Very ambitious problem indeed, but from my perspective the designer of such a list would deserve massive congrats.

Would be even neater if each med had polling added onto each one for effectiveness.

2 type of polls: 1) Double blind controlled studies 2) Anecdotal (anyone can vote yay or nay).

This would prob make a lot of people's life a lot easier.

 

[Bluejay1]

However, the only thing the web doesn't really need is another partial list, or even worse a partial list with inaccurate information.. So could get tricky if project only done halfway

 

[Bluejay1]

BTW I laughed at 'MILF analogue' as well.

 

[Bluejay1]

Is there actually such thing as MILF analogue.. You can guess what comes up in the google search, the results have nothing to do with chem-research

 

[Bluejay1]

I feel like I'm going to eternally be stuck as greenlighter at this pace..

Anyway this is a good thread, it will just take a lot of people to make such a list come true. IMO drugs are worth the effort, but got to find time first

 

[seep]

...it will just take a lot of people to make such a list come true...

What's up man.

You're actually one step behind here. I read this today:

TC-1734 is a neuronal nicotinic receptor (NNR) agonist in development for the treatment of cognitive and memory disorders. It was designed using Pentad, the company's in-silico engine for selectively targeting specific CNS receptors.

This is several degrees of magnitude more comprehensive than a list, and it allows you to remove the "undergoing trials" bit and pre-empt every potential ligand for every known homosapien protein.

 

[Bluejay1]

Hey which list is that from? Does Targacept have some kind of all-encompassing list we don't know about? You talking about their platform, that PentadTM thing?

 

[Bluejay1]

Posting a link to the page I think you are referring to:
http://www.targacept.com/wt/page/pentad

It seems like every pharmaceutical company has such advanced platforms for drug development, even some Universities have them.

Unfortunately these things are only available if you are a Targacept employee :

"
Biology Database
We have developed and gathered an extensive database of biological data from a library of diverse compounds over 20+ years of leadership in NNR research—the most extensive experience in the field. Our data archive is bolstered by our own sophisticated cellular and biochemical techniques that are predictive of a drug's therapeutic potential, including:
Novel pharmacological screening methodologies
Novel behavioral screening methodologies
Proprietary receptor targets and clonal cell lines
High throughput pharmacological screening capabilities
High throughput electrophysiology
"

Not that it would be of terrible use to me, it still would be interesting to see what's going on.

 

[seep]

I don't think that company is privy to information the rest of the industry lacks. And it sounds a little bloated. "Novel behavioral screening methodologies" is anything and "proprietary receptor targets" is every compound. I have a lot more to say about this but it falls into the Theater of the Unfathomably Boring.

The computerized ligand generators help beef up NDA's though.