A hyptothesis in regards to your GABA receptors, while taking benzodiazepines...

[Charles Bronson]

I had read somewhere on an online University database about the disinhibitory effects on GABA when it crosses your BBB, and something caught my site. Glutamic acid (Glutamate, which I believe is readily available from your local pharmacy), except I'm not certain that Glutamate, in pill form, readily crosses your BBB. Could anyone offer some input in to this (Wikipedia has destroyed our attention spans, so if somebody would be able to fill me in on the effects of OTC Glutamate and it's possibility to cross your BBB, then I'll possibly get some later on. Thank you BL team.

 

[Mr Blonde]

Glutamic acid is an excitatory neurotransmitter, so you'd imagine supplements to initially have some sort of 'stimulating' effect of one kind or another. It does get metabolized into GABA eventually, but having extra GABA in the brain doesn't necessarily mean it will cause dis-inhibition or effects similar to GABA-ergic drugs; remember, drugs like benzodiazepines and barbiturates function by modulating how GABA effects receptors rather then just increasing levels of it.

 

[Charles Bronson]

Yeah but Mr. B, I had no intention on taking it to get high. I had the intention of taking the prescribed dosage of 2 x Glutamine 500 mg for 25 days to replenish my bottle.

 

[Mr Blonde]

Ah, OK... I'm confused, why do you want to use the glutamic acid?

And it does cross the BBB, via an active transport mechanism.

 

[Charles Bronson]

Glutamate plays an important role in the biosyntheses of GABA.