A fentanyl analog without NaBH4

[Armadillo]

You can do many fun things to that double bond.

(off-topic) I want to try some 2C-CN and DOCN! Another case of the nitrile being, likely, OK. (/off-topic)

 

[haribo1]

^ ...and even if ya did ....

I WOULD get it, seriously! Does anyone know of a cheaper way to get these services (live via a uni server or whatever)?

 

[dorothyperkins]

I think every uni with a chemistry department will have it, you should be able to use it from the library. It would be really nice to be able to use from home, in theory all you need to do is trick it into thinking your logging in from a uni computer. ie. fake your ip address, but then you need the fake ip address to forward incoming packets to your computer so it would probably mean hacking their network!

 

[johanneschimpo]

^ I don't know jack about computers, and their terminology, but my school lets you use a proxy server (I think thats what it is) so you can access all that goodness from home. Score!

 

[haribo1]

I'm not in college, I'm a bit long in the tooth for all that stuff..

 

[MattPsy]

Yeah I have access to that stuff whilst off-campus through a proxy, but I don't use it cuz I don't want to become accustomed to using it lest I become inable to find content without it.

 

[Adrenochrome]

Are you guys saying you your school allows you to access sci-finder via proxy?
My school only has two comps with sci-finder installed and they say you can only use it for 30 minutes at a time...

 

[LuxEtVeritas]

some schools have far better situations of that nature than others

 

[dorothyperkins]

how do you find things without it?

 

[johanneschimpo]

Are you guys saying you your school allows you to access sci-finder via proxy?
My school only has two comps with sci-finder installed and they say you can only use it for 30 minutes at a time...

OT, but do you go to a big or little school? Mine has something like 18k students.... that might be part of the reason we have so much access

 

[fritzy]

I would love to use them, but I don't have $20000 free at the moment...

<...sigh...>

They don't cost $20,000; in most cases, all you need is an active student email account to download a fully licensed copy of the user software onto your home computer. To do that, you just need to sign up for a science course (or often times just a basket weaving class) at your local major university as a "continuing education student", or whatever they call it where you live.

Alternatively, if that's too much trouble, most of the times there is open access to these databases in the science and engineering libraries at the aforementioned institutions. You walk up to the terminal (possibly sign in, depending on the library), and you're set.

Really, if you're interested in chemistry as a hobby (and aren't we all), then there's no excuse not to get access to this. Really, doing these sorts of queries independently is enormously gratifying, and will bring you quite a rush.

To get you started (and force you to get off your arse and go to your local university library), here are a few articles on reactions related to what you described.

Bioorganic & Medicinal Chemistry Letters, 17(8), 2171-2178; 2007
Journal of Medicinal Chemistry, 48(24), 7720-7732; 2005
WO Pat 2005040166
Journal of Combinatorial Chemistry, 7(2), 258-263; 2005
Journal of the Serbian Chemical Society, 67(12), 793-802; 2002
European Journal of Medicinal Chemistry, 35(9), 839-851; 2000
Tetrahedron, 55(24), 7625-7644; 1999
Journal of Organic Chemistry, 57(14), 4037-8; 1992
Collection of Czechoslovak Chemical Communications, 55(7), 1828-53; 1990
Journal of Organic Chemistry, 55(13), 4207-9; 1990
Journal of Medicinal Chemistry, 32(5), 968-74; 1989
Bulletin des Societes Chimiques Belges, 90(7), 749-55; 1981

 

[Ham-milton]

enormously gratifying, and will bring you quite a rush.

You and I've got different idea on what qualifies a "rush" I think

 

[Smyth]

Seriously, this guy lives in the UK and their attitude is different here. Viewing "protected" content is seen as something of a taboo if you arent a university student, etc. I was asking around and they were basically trying to fobb me off. Whereas in America, even my aunt was able to get onto the library computers at the local university, and I was left unattended there to get what I needed. Notice how you get treated differently depending on where you are located?

If you want to do us a favor, make a zip of those files and upload them to rapidshare or something

I think ive already read most of them, but people would rather you did that than telling my buddy he cant get the articles because he hasn't applied himself or made an effort etc. Those with an elitest mentality probably tried to block him, deliberately with the intention of making it difficult.

 

[fritzy]

You and I've got different idea on what qualifies a "rush" I think

I have to admit, perhaps my adrenal system is a little different. I remember when I first learned how to do substructure searches with Beilstein and Scifinder. For weeks, I spent 15-18 hours a day note taking, reading, searching, and photocopying hundreds (and eventually thousands) of articles. I realized how much knowledged I had available to me, and I felt so fortunate to be a student at this time in history. For a creative young person with an appreciation for the "rules" of organic chemistry, and some practical interest in how to apply it, it was hard not to dive in completely. It was during this time I switched to majoring in chemistry, and it's been a very rewarding life ever since. I'm so grateful for those very manic years, and I only hope other people can have the same experience.

 

[Smyth]

What you are overlooking is that even if you get local university access (the university is 15 minutes walk away), you'll still not be allowed to use the computers there.

Chemistry is a practical subject anyway, and what you are suggesting is becoming a perpetual student.

Even if one has the best theoretical concepts in the world, if they fail to demonstrate the ability to prove themselves in the lab then they wont be able to make an impact on issues of real-life importance, which is where it counts.

I'm swamped in literature in anycase, I have more than I can absorb and it's not fair on the trees

 

[Bondmaker]

at 25-50 micrograms/dose, fentanyl itself is what we would think of as quite a potent drug, (on the order of LSD. How much more potent can you make it by SAR?, and why would it be worhthwhile, all fentanyl analogs are illegal even before they are made. With aniline you can put together norfentanyl in a jiffy by using sodium triacetoxyborohyride and phenethylpiperidone, followed by propionylathion. Fentanyl can KIll you, huh. Addicting as hell. What do you want to mess around with your life (and others lives) for? Smoke some good weed and drink beer. All you'll get is a beer gut, not 25 years in the can!

 

[fritzy]

What you are overlooking is that even if you get local university access (the university is 15 minutes walk away), you'll still not be allowed to use the computers there.

Database access is entirely campus policy-dependent, but generally this stuff isn't under lock-and-key most of the time (except when the library shuts its doors). I've done A LOT of travelling in my time, and have managed to access Beilstein on public terminals on university campuses in several different countries without logging in (Austria, Sweden, USA, Netherlands, Germany, Belgium, etc.).

I also happen to know a thing or two about the licensing of Beilstein at haribo1's local major world-class university, and that they are one of the major hosts for it for Northern Europe (covering institutions in the UK, Ireland, and Scandinavia), and that user ID's aren't required by the library at the public terminals.

Besides... this is all "theoretical" chemistry that we are talking about, so why worry?

Chemistry is a practical subject anyway, and what you are suggesting is becoming a perpetual student.

You say that as if it were a bad thing. No, I'm suggesting that to gain access to the desired information, you will have to be affiliated with an institution with the necessary license, and for academic instutitions you have the choice of being either student, staff, or faculty. Gaining student status is a lot easier than the other two options, and he just might learn a thing or two in the process.

I'm proud to call myself a "perpetual student" -- even though my official status as such ended years ago. At least for me, the day I stop learning is the day I die. Why should it be different for him?

Even if one has the best theoretical concepts in the world, if they fail to demonstrate the ability to prove themselves in the lab then they wont be able to make an impact on issues of real-life importance, which is where it counts.

True enough, but if we are to believe various statements he has made elsewhere, I don't think this is a branch of chemistry that he wants to apply in real life. Isn't that right?

Regardless, if you try to do practical chemistry without some solid theory underlying it, you won't be very successful. As the old saying goes: "six months in the lab will save you an afternoon in the library".

I'm swamped in literature in anycase, I have more than I can absorb and it's not fair on the trees

That's why I love adobe acrobat. I shudder at the number of trees I killed before I started carrying around USB sticks.

 

[fritzy]

Seriously, this guy lives in the UK and their attitude is different here. Viewing "protected" content is seen as something of a taboo if you arent a university student, etc. I was asking around and they were basically trying to fobb me off. Whereas in America, even my aunt was able to get onto the library computers at the local university, and I was left unattended there to get what I needed. Notice how you get treated differently depending on where you are located?

If you want to do us a favor, make a zip of those files and upload them to rapidshare or something

I think ive already read most of them, but people would rather you did that than telling my buddy he cant get the articles because he hasn't applied himself or made an effort etc. Those with an elitest mentality probably tried to block him, deliberately with the intention of making it difficult.

"Elitist mentality?" Bah! No, I don't think he is blocked by anybody. He most certainly can get the articles if he wants them -- the main university library is open everyday of the week (excluding holidays). If that's too much (I do appreciate that he is disabled), he can sign up for a distance learning course to get an active student email account to get started, and he can download the software onto his home computer and search for articles 24-7. How empowering is that?

I just think he'd do well to give university life a try, and I think he'd find a structured study of chemistry (or a related field) to be very intellectually stimulating. A formal education in chemistry would be far more useful to a wider range of problems than endlessly gleaning opiate chemistry off the internet. He's a gifted individual, and the world would benefit from him applying his mind towards its problems. To entice him, I even did the SciFinder scholar search for the necessary articles -- all he has to do is gain access to pick them up. Opioid chemistry is not something that really interests me, and so I shall politely decline to acquiesce on the request to do this part.

 

[Bondmaker]

I tried to get..

Access to sci-finder, which encompasses chem abstracts, and just about all that's known, that's been published, and so definitely "empowers" someone to get all the answers they would ever want, but was told no by my company when i went off-line. So i know that somebody has access to it here, and if i'm not too pesky, just might get a little help studying things i'm interested in and good conversation. I am disabled by a crippling disease and don't get out much, so you people may find that i can be a bit of a pain in the ass, who can't shutup . If you find that i am just tell me to shutup and i will

 

[fastandbulbous]

I am disabled by a crippling disease and don't get out much, so you people may find that i can be a bit of a pain in the ass, who can't shutup

And this makes you different from most of the people who regularly frequent ADD in which way?

We're probably all seen as socially crippled drug geeks who don't get out much by most of 'normal' society (and a fair few BLers as well!), so don't worry - I have embraced my sad geekiness - if you actually love this status and show such to others, it will eventually become an asset (it was through standing in a nightclub, talking about poisons, pharmacology - and cats, but that's just an aside - that I ended up in a relationship of 13 years with my wife as she's a female geek equivalent).

That's my take on it & I'm not going to change my opinion just because other people want to talk about sports, shagging etc In fact, I can even generally introduce the geek angle into any conversation (with sports it can be things like the principals behind 'bending it like Beckham', for shagging, the biochemisty of orgasm, just ensure the initial premis is interesting/funny and people actually generally find it interesting. Topics like what physical/chemical changes occur during orgasm will generaaly be of interest to most people, because most people really like sex)

If you find that i am just tell me to shutup and i will

No need, nobody else here shuts up; they continue to gibber incessantly regardless of being told to do so by mods here. Might have something to do with me & vecktor (or should that be vecktor & I) being two of the worst offenders!