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Misc A drug which can be taken PRN for sleep and kicks in as fast as alcohol?

There's not a substance that feels like alcohol and isn't alcohol. The reason alcohol feels like alcohol is because it hits a certain receptor in a specific way. If you want to achieve sedation without addiction, that's a different story. If you're willing to compromise (not having alcohol or benzos), there are herbs you can try. Kava has already been mentioned, and mulungu is worth looking into.
 
If you can get it, choral hydrate is what you want. But good look finding some.
 
I really don't get it why seroquel / quetiapine is prescribed so often as a sleep aid (besides the huge revenue it creates for AstraZeneca, of course). The same with other neuroleptics, and to a lesser extent also the sedative antidepressants. Hey, you're using antipsychotics just because of some of their side effects!

Yeah, they say seroquel is a low-potency one and an atypical. With 25-50mg it's probably not serious. Nevertheless it IS antidopaminergic with as less as 50mg, causing dysphoria and restlessness which is just overpowered by the sedation. And there is evidence that the ugly potential of inducing diabetes (!!) is not dosage dependent. Some people become adipose w/o eating much more, just from neuroleptics.

What you're looking for is a) a powerful / high-affinity, centrally acting H1 antihistamine with a short duration (so that it doesn't cause hangovers - sadly most of the old, sedating antihistaminergics have been designed to be long-acting afaik) and without anticholinergic / etc. properties.

And/or b) an anti-noradrenergic agent. This could either be an autoreceptor agonist like clonidine (a good sleep aid btw, non-addictive, not dysphoric and dirt cheap) or some adrenozeptor antagonist.

These are the mechanisms why things like mirtazapine, quetiapine etc. are sedative / hypnotic. Try a non-sedating neuroleptic once, and you'll know their true nature.

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If your sleep problems are due to disrupted circadian rhythm, then give melatonin a try (maybe combined with doxylamine - OTC antihistamine - for the first days).
 
szuko000 said:
The only OTC sleep aid that *almost* qualifies in your list is doxylamine however, it does not produce a high or anything it will just kick in fast and put you to sleep. You are not going to find anything that matches what you want unfortunately.
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Is doxylamine faster and shorter working than diphenhydramine?
 
Hydroxyzine HCL is what you want. The pamoate version takes too long. Hydroxyzine HCL kicks in fast and knocks you out. I never have noticed any hangover and I always felt well rested afterword.
It's hard to find, but that choral hydrate is the king knockout drug. The shit is strong enough that you have to sign for each dose, lol. Seriously, try the hydroxyzine HCL.
 
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