A cute molecule (AI derrivative)

[Jamshyd]

Btw, what would happen if another amine group was added on the other end on the pentagon ring (what do you call that?)

Also, what if the one amine was moved one carbon atom counter-clockwise and extended by one more carbon, a la jimscaline?

Here are some nice pics for more chemical masturbation

 

[Black]

i'd call it cyclopentane ring or simply 5-ring.

i don't think the first one wouldn't be active. afair no phenethylamine with such strongly hydrophilic (+ hydrogen bond forming groups) is active. it would be much more difficult to get that one over the blood brain barrier resulting in increased dosage requirements and more peripheral side effects, even if it were active.

the second one could be active, but i don't even know if it would rather be a entactogen or psychedelic (or maybe stimulant), so i don't dare to make any predicitions here...

 

[dread]

Referring to the lower structure:

Who knows if it would be active. The side chain & amine are in an efficient position for 5ht2a binding, but then again, the substitutions on the benzene are not optimal for 5ht2a agonism... The ring substitutes would probably work for a SSRA as they do on IAP, but then again I don't know if the side chain & amine work for serotonin releasing.

Tricky.

 

[Hammilton]

It's unlikely that it would be. Phenethylamines generally require methoxy groups (or constrained equivalents, as in the Dragon-FLY compounds) to be 5HT2a agonists. Would probably have serotonin releasing properties, but probably very limited or no DA or NE releasing effects.

I'm wondering if there might be some hope for the top compound. 2C-N is active, and it's probably metabolised to 2C-Amino. But it only has a duration of about 4-6 hours, so perhaps not. Symmetry may be neat, but I wouldn't bet on it's activity.