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7 hydroxy mitragynine

Yohimbine causes visuals? How much did you take? I thought it was just a stimulant vasodialator??
 
Ham-milton said:
I always thought Kratom felt like exactly like Strattera or Effexor.
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I am glad I am not the only one that gets a SSRI'ish effect from Kratom. Happens mostly on the tail end though, when I am coming down. That same zombieish feeling. It sucks! Think that this comes from the 7-HO itself?
 
Yohimbine is definitely psychedelic...feeling like a low dose of mushrooms or morningglory and a high dosage of ephedrine. Shitty feeling. When mixed with amphetamine, it was more psychedelically active.
 
Does anyone else think that the 7-OH mitragynine is made rather than extracted? I know that the Chinese chemists found an oxidation method using polyvalent P compounds rather than the icky lead tetracetate? If the stuff is 13x morphine and people reckon that you get 4mg when you buy it, your getting like 52mg of morphine at a hugely inflated price?
Unrelated, I notice that thebaine containing poppies are not illegal to grow but the thebaine is mainly in the routes, but most everywhere in the plant. ..
 
@lux/veritas: i don't think so, but i will recalculate the whole thing once more.

i need to add to my suggested potency this important fact:
iv morphine is 3 times as potent as oral, so oral mitragynol would be 4 times iv-morphine.
the oral bioavailability of mitragynol btw is supposed to be near 100%, but i don't have refs for this right now.
 
^ it depends on what study you look at as there are varying numbers depending on the tests used and the such

such as :
Among these alkaloids, 7-hydroxymitragynine showed the most potent opioid effect on the electrically-stimulated contraction (pD (2) = 8.38 +/- 0.12). The potency, calculated using pD (2) values, was 30- and 17-fold higher than that of mitragynine and morphine, respectively. Antagonism of naloxone on concentration-response curves for 7-hydroxymitragynine confirmed its opioid effect. These results suggest that the opioid effect of M. speciosa is mostly based on the activity of 7-hydroxymitragynine.

and

When administered subcutaneously to mice, 7-hydroxymitragynine produced antinociceptive effects about 5.7 and 4.4 times more potent than those of morphine in the tail-flick (ED(50)=0.80 mg/kg) and hot-plate (ED(50)=0.93 mg/kg) tests, respectively
 
Hope this isn't taboo here in the advanced forum.......

Any idea what oral dosage should be for 7-HO-mitragynine?

I have vague anecdotal "guidelines" that suggest 10 to 20mg.

Sound about right?

Shit''s sort of expensive...... so, not really looking to waste it.....
 
yea, my calculations come quite close to the values of your 2 studies, lux&veritas (the latter comparing iv-quantities, i guess), although they suggest a small bit higher potency. :)
 
Also, any idea how just the intermediate 7-Acetoxy Mitragynine stands up to the 7-HO?
 
^Good question. I cannot remember reading of any specific tests although it's certainly the intermediate in making the 7-OH.
 
Wouldn't 7-AcO-MIT end up converted to 7-HO-MIT in the end? I'm pretty sure it would. I guess the whole idea is an extended/dual action where the product becomes slowly converted and both effect profiles are experienced.
 
no, 7-aco-mit wouldn't metabolize to mitragynol, as there is another readily hydrolizable ester in the molecule ( a methylcarboxy) that would hydrolise even quicklier.
that's btw the reason for the short half-life of mitragynine/mitragynol.
 
You're sure that it wouldnt go from the aco to the ho? Because that is what I've heard.
 
^^thats the theory with 4 position tryptamines, but I dont know about these mitragynine analogs...
 
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