6 Chloro MDMA

[jackson2004]

Would someone have information on the effects, toxity, and dose of 6 Chloro MDMA,

 

[wungchow]

Probably neurotoxic. Just look at 6-OH dopamine. -OH and -Cl groups are generally bioisosteric in terms of how they are recognized by proteins (but obviously differ in polarity)

 

[MurphyClox]

A chloro substituent should raise lipophilicity IMO and, therefore, BBB-penetrability. So, if this stuff is neurotoxic (and I second wungchow here), it should be even worse 6-OH-dopamine.

Unfortunately, displacement of the methylene bridge, leaving the 3,4-dihydroxy derivative is a reported metabolism pathway. This even strengthens the proposed toxicity.

Peace! Murphy

 

[jackson2004]

Thanks for the heads up.

 

[jackson2004]

Would same apply to 6 Nitro MDMA

 

[MurphyClox]

Not per se. As wungchow elaborated nicely, -OH and -Cl are bioisosteric. This doesn't count for the nitro-group.

Then again I would not want a nicely activated nitro-aromatic to enter my body. Geeee...

Murphy

 

[Ham-milton]

Ah, I think you all worry about the aromatic nitro's too much. But then again, I've never seen them used on low potency drugs.

I would let a 6-chloro or a 6-nitro-MDMA or MDA enter my body.

end of discussion.

 

[mad_scientist]

Remember 6-methyl-MDA is inactive, so the 6-spot may not be very tolerant to bulk. On the other hand MMDA-2 with a 6-methoxy group is active, and its N-methyl derivative too.

I would also be concerned about the toxicity of 6-chloro or 6-nitro MDMA or MDA. Why the 6-position anyway? The 5-position is more likely to be the sweet spot I'd say, 5-methyl-MDA is significantly more potent than MDA itself according to Nichols paper on it.