• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

6, 5-APB + MDAI combo

M

mister

Bluelighter
Joined
Jul 8, 2005
Messages
1,632
Hi ADD, how toxic or dangerous would it be to combine x-APB with MDAI?
not sure if this is the place to post this but I trust your knowledge more than anywhere else, especially when playing with my brain
thanks in advance
 
who knows?

6 APB has killed all on its own and has lead to quite a few hospitalisations with hyperthermia and serotinergic toxicity.

MDAI has killed all on its own.

what exactly are you trying to achieve other than ingesting a random mixture of unidentified drugs you have lying around ?
MDAI serotonin reuptake inhibitor releaser,
6 ABP serotonin reuptake inhibitor and releaser dopamine releaser, norepinephrine releaser, also a competitive monoamine oxidase inhibitor as well as a 5-HT2c agonist.

nobody can tell you if it is safe or not, just as nobody can tell you if any of these drugs on their own are safe or not, nobody can tell you whether it is a good idea to mix them, that is why they are research chemicals.

better to trust your own judgement, but don't don't bother to come bleating if it goes wrong, that is the other side of playing with unknowns. That is why they are called RC's, [I]R[/I]esearch Chemicals or Random Crap depending on your opinion.
 
thanks for the reply Vector, and I appreciate it.
I understand that the chemicals people order could be anything, but hypothetically speaking, if said drugs were in fact 6, 5-APB and MDAI, how would they react with each other?
from the chemical composition of each, would it pose a risk if they were both ingested at once?
 
If you mean drug interactions, then yes, there's a high probability of interactions between two drugs having effects on both release and re-uptake of 5-HT, DA and NE. Throw the (weak?) MAOI activity of 5/6-APB into the mix and there's a very real risk of hypertension and hyperthermia, or serotonin syndrome if you're really out of luck. Drug interactions aren't necessarily dangerous or even unpleasant, but they may very well be.

If you mean the drugs actually reacting with each other in your body, then no, that's very unlikely. It's known to happen with cocaine/ethanol and methylphenidate/ethanol, but cross-metabolites of drugs are rare.
 
vecktor said:
6-APB has killed all on its own and has lead to quite a few hospitalisations with hyperthermia and serotinergic toxicity.
Click to expand...

Is there evidence of this? Maybe I've missed the reports but this appears to the first time I've heard of a death as a result of using 6-APB.

Hospitalisations wise there were a number from roughly this time last year I think, but if they are the ones you are referring to, the likelyhood is they were pips being sold as "benzo-fury", as evidenced by that report by Baron in "Drug Testing and Analysis" - "Analysis of legal highs – do they contain what it says on the tin?"

Saying that I agree with avoiding combining the three.
 
Last edited:
chasing_s said:
Is there evidence of this? Maybe I've missed the reports but this appears to the first time I've heard of a death as a result of using 6-APB.

Hospitalisations wise there were a number from roughly this time last year I think, but if they are the ones you are referring to, the likelyhood is they were pips being sold as "benzo-fury", as evidenced by that report by Baron in "Drug Testing and Analysis" - "Analysis of legal highs – do they contain what it says on the tin?"

Saying that I agree with avoiding combining the three.
Click to expand...

there was a tox report knocking about which refers to hyperthermia, confusion and symptoms characteristic of serotonin syndrome where 6-APB was involved. the report refers to a report of a death in eastern europe? through the EU monitoring system. If this report is public domain I will post it.
 
Ok cheers, probably not something I'll have likely to have seen then, fair enough. Thought it might have been something posted on here previously that I missed.

Vaguely related to the European monitoring, but likely going off topic here, am I the only one to find it odd the the EMCDDA report for last year mentions 5-APB and yet not 6-ABP?
 
vecktor said:
there was a tox report knocking about which refers to hyperthermia, confusion and symptoms characteristic of serotonin syndrome where 6-APB was involved. the report refers to a report of a death in eastern europe? through the EU monitoring system. If this report is public domain I will post it.
Click to expand...
This was in combination with MDAI I believe, where deceased combined both in quite high doses IV. Unfortunately I can't link to the info and resource is offline at the moment. If I can dig out more info, I will post it here.
 
thank you all for your replies, I will be avoiding this combo and advising others the same thanks to your advice :)

thank heavens for Bluelight and the knowledgeable people here
 
You must log in or register to reply here.
Top