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5mg MDMA a day question?

severely etarded said:
It's an interesting idea. I'd like to see pharmacologic studies
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Therapeutic MDMA studies don't really go into this sort of idea. I do not think 5mg will do much though.

I have seen reports that 40-60mg produces a nice mood lift without the full on roll effects. Probably it also won't kill tolerance or cause as many health issues as the 100mg standard roll (though I have no idea by how much).
 
5mg a day? Wont change nothing, and how could it have therapeutic benefits when you don't even notice you took some?

I wouldn't reccomend it at all. Try to work out instead, that has proven therapeutic benefits.
 
Exstazy said:
5mg a day? Wont change nothing, and how could it have therapeutic benefits when you don't even notice you took some?
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Maybe it could promote upregulation?

Found this on another site, but unfortunatly couldn't find the study of origin :
§ Small doses of MDMA (equivalent to a human dose of <1mg/kg) cause up-regulation. This appears to stimulate the development of new serotonin neurons.
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You'd think that if anything at best it would do nothing, at worse would slowly fry you in tiny ways.

Who's keen to get a bucket full of rats and try this out?
 
@laugh, it's not cruelty it's "scientific studies" I think that's the excuse that the mega corporations use.

FREE TIBET & PUSSY RIOT!


Hahahaha but nah Laugh I do agree with you.
 
I too have seen "small/below threshold doses of MDMA cause serotonergic neuron sprouting" yet nothing scientific to ever back this up

And 5mg a day of MDMA over a long period hasn't proven to cause anything positive let alone recreational in the slightest and you have everything to loose and nothing to gain doing it
 
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I just checked out this link in the new MAPS section, I wonder how much and how often they were dosing?

http://www.bluelight.ru/vb/threads/682213-MDMA-as-a-replacement-for-SSRIs-for-treating-depression

It is about MDMA being more helpful than SSRIs, LOL! I always hated being put on SSRIs!

Exstazy said:
5mg a day? Wont change nothing, and how could it have therapeutic benefits when you don't even notice you took some?

I wouldn't reccomend it at all. Try to work out instead, that has proven therapeutic benefits.
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Lol, I work out everyday and only use MDMA 4-6 times a year, I am just wondering what could come of this in the medical field. I am very aware Erowid put MDMAs active base dose at 30mg, However I believe this may just be in reference to recreational statistics and 30mg but be the dose that psychoactive effects are displayed at.

MrSpeedyG said:
And 5mg a day of MDMA over a long period hasn't proven to cause anything positive let alone recreational in the slightest and you have everything to loose and nothing to gain doing it
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Good I am not interested in recreational benefit, I am wondering if it could have a potential for aiding in depression or suicidal thought process.

Saying you have everything to loose and nothing to gain may pertain to someone with great chemical balance, but not everyone in the world is the same so that is mildly ignorant to say, this is a serious question.
 
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I think you are misinterpretting that they are saying using MDMA in the same fashion as an SSRI - daily usage, is better than an SSRI. This is not the case. They are saying how MDMA assited sessions are excellent for overcomming depression and other mental illnesses, not use as a daiy medicine.
 
MrSpeedyG said:
I think you are misinterpretting that they are saying using MDMA in the same fashion as an SSRI - daily usage, is better than an SSRI. This is not the case. They are saying how MDMA assited sessions are excellent for overcomming depression and other mental illnesses, not use as a daiy medicine.
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I get that, I guess there just hasn't been any research on low dosage MDMA therapy.
 
EarthBounded;11710453 Good I am not interested in recreational benefit said:
I am all for getting MDMA legalised for use in psycotherapy as it has shown excellent results espeicllay in PTSD.

I am not mildly ignorant in general, let alone on the topic of MDMA both recreational use and for its legitamte purposes... The only ignorance here is from your part in saying that.

MDMA at sub-psycoactive doses does absolutely nothing, so administering sub-psycoactive doses for a long period of time will do nothing however as I had originally stated it may not do anything on a psycological scale but as MDMAs neurotoicity mechanism has not been found, say breakdown of MDMA itself and not monoamine release was the cause of neurotoxicty (a direct MDMA metabolite being neurotoxic) it could mean that whilst psycologically nothing is happening, there may be serotonergic destruction still occuring due to, yes small amount,s of a neurotoxic metabolote being presenet and thus presenting my, ignorant acording to you, everything to loose (potential serotoninergic damage) with nothign to gain (no psycological effects). So I ask you retract your statement of my ignorance.

Keep in mind that what I have just stated in the above paragraph may or may not be true due to MDMAs debatable/potential neuroxotoxicty whether it is a direct metabolite of MDMA that is neuroxotic, or whether neurotoxicity is dependent on monoamine release etc etc.

I see what you are saying though, you are questioning if MDMA at super low doses is possible as an anti-depressant however it simply isnt so even though I too wish it was. Something like MDAI, a pure serotonin releasing agent that hasn't been shown to cause neurotoxicity would be much, much more suited to this purpose.

MDMA has great potential at relieving depression however not by fixing a chemical imbalance or something like that, but rather via inducing a person into a psycological state unique to MDMA and many other MDxx derivitives that then allows them to work through their depression or look back onto the painful-when-sober events that triggered an illness such as PTSD for example whilst under the influence of MDMA.
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EarthBounded said:
I just checked out this link in the new MAPS section, I wonder how much and how often they were dosing?
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Doses vary in reports I see, between 50mg (low)-125mg (full). Sessions were between one to two, from what I see.

I would personally think 50mg-75mg would be a better choice. I just can't imagine a therapy session happening while fully rolling.

I'm not so certain that MDMA is the right drug for PTSD treatment, personally. If it's the "opening up" aspect that is the true benefit, and if what I read about that aspect of MDMA is true (oxytocin release via some sort of unclear tie-in with 5-HT1A), then there may be less neurotoxic / amphetamine type ways to achieve this.
 
MrSpeedyG said:
it could mean that whilst psycologically nothing is happening, there may be serotonergic destruction still occuring due to, yes small amount,s of a neurotoxic metabolote being presenet and thus presenting my, ignorant acording to you, everything to loose (potential serotoninergic damage) with nothign to gain (no psycological effects). So I ask you retract your statement of my ignorance.
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Ignorant was a bad word, I wasn't trying to be rude, I just meant depending on the person one may have something to gain.

I would be curious to the Neurotoxic effects of 5mg MDMA a day administered with Alpha Lipolic Acid daily as well, this could prevent all neurotoxins I am obviously not positive but in theory it is a possibility. How much different would neurotoxicity be with 5mg a day MDMA be compared to 5mg a day d-amphetimine?
 
Sorry dude was having a bad day didn't mean to sound like a dick with the ignorance shit lol, im a very easy going person

I honestly couldn't see any therapeutic benefeit in any shape or form at 5mg MDMA daily... IIRC MDMA at just below threshold doses puts some people in a state of anxiety or likea never ending wierd feeling come-up. I don't think there would be any monoamine release at that dose either or oxytocin, which IIRC 5HT1A receptor activation is key in MDMA-induced oxytocin realease.

5mg of MDMA compared to 5mg of d-amphetamine in terms of neurotoxicity isn't something you could really compare, kind of like apples and oranges. For one, mg for mg d-amphetamine is much more potent than MDMA, but then again amphetamine is primarily a dopamine/adrenaline releasing agent with miniscule serotonergic action whereas MDMA is quite the opposite... If we were comparing say methamphetamine to amphetamine, both dopamine releasing agents, in terms of equal mg-mg neurotoxic potential then comparison is logical. It also brings to rise the mechanism of neurotoxicty, whether it is dependent on monoamine release and subsequent oxidate stress from the break down of supraphysiological monoamines or whether it is a metabolite of the drug itself. Then there is also which monoamine system we would be looking at for neurotoxicty, the 5HT system or the dopamine system.

So as you can see its not really something to compare. Maybe if 5mg a day of MDMA were to bring some sort of therepeutic action then yeah I could see a reason for looking into this, but the reality is MDMA does not work in that fashion... It's a once off sort of thing not a daily drug.
 
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