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5HT1A Agonism, why does buspar suck?

Well, direct agonists of DA and NA feel most distinct from reuptake inhibitors, both standing distinct from releasers. This is even more the case with 5ht. Compare a selective SSRI at any dose to, say, MDAI.

ebola
 
All drugs do to this site is downregulate the cAMP level in the cell, try goin on drugs for the 4-HT receptor instead, these upreglate cAMP
 
Heh...if madsci weren't making a series of BS-smelling posts that day, and we were to thus give this some credence...it could be a receptor subtype named after the exogenous ligand to which it responds, just as we call a certain subtype of glutamate receptors NMDA receptors...

I'm pretty sure that there's no receptor subtype known to respond to 4-hydroxyl-tryptophantryptamine.
[you need 200 mg of caffeine stat, ebola!]

ebola
 
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er, 4-hydroxytryptamine?

Buspar works for some people but not others.
 
Yeah! Take tegaserod for your anxiety/depression! Not 5-HT1a agonists.

(I assume he meant the 5-HT4 receptor...)


Medieval, since no one else appears to wish to answer your question: Buspirone is only a partial agonist at 5-HT1A receptors; it hits a great many autoreceptors; and is a D2 receptor partial agonist. I believe 5-HT1A agonists may produce their anxiolytic and antidepressant effect by triggering the release of dopamine in the mesolimbic pathway, so if Buspirone is blocking D2 receptors and only activating them weakly...

There you go. That's a good start, I think.
 
I think i figured out why buspar suck, on another forum someone mentioned that the dose may just be way to low.

Buspar also agonizes the 5HT1A autoreceptors wich would destroy any benefit the buspar my give you, but over time those receptors desentize, now the problem with normal dosing is that you would only get minimal 5HT1A postsynaptic agonism.

I started taking 40mg and will go up to 120mg, dont try this it home tough i started sweating, getting terrible brainzaps and felt like complete crap, it was even worse then mdma's comedown 2 days after taking it.

But i'm confident it will get much better with patience, i do understand why ppl dont like buspar tough LOL.
 
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