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5-HT Receptor Agonists - The Triptans

SpunkySkunk347

SpunkySkunk347

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I'm interested as to what the mental effects of serotonin agonists would be like, particularily the Triptans (Sumatriptan, Naratriptan, Zolmitriptan, and possibly the triptan with the widest variety of 5-HT subtype affinity, Eletriptan)

Most triptans lack affinity for the 5-HT2a receptors, so there is a real lack of any hallucinogenic effects, but perhaps because of their affinity of other 5-HT subtypes (particularily the 5-HT1a, 5-HT1d) they would have empathogenic, anxiolytic, and euphoriant type effects, perhaps in higher doses.

Someone I know, who had know prior knowledge as to the method of action of sumatriptan, ingested sumatriptan for treatment of a migraine as prescribed by her doctor. About an hour and a half after ingestion, she reported effects one might expect from a 5-HT agonist, including euphoria.
 
Very nice!! In fact, I wanted to open exactly this kind of thread yesterday but didn't find the time.

It was stated elsewhere that sumatriptan in particular doesn't posess any recreational value. But after talking some times with a colleague who suffers from occasional migraine attacks, he assured me that his triptan of choice (sumatriptan) does more than just relieving the pain. He described some light but certainly feeled euphoria, as in the post before. Just a coincident?!

Asking him, if this could be caused just by taking away the enormous headaches (that sometimes even cause vomiting!), he told me that is was definitively more. The euphoria is unconnected to the pain-relieving effects. Now it would be interesting to see, how migraine-naive people react to sumatriptan or alike.

The discussion is open :)

Peace! Murphy
 
The triptan drugs are all like, what, $25/pill? I think any kind of slight benefit one gets out of them simply does not add up to the price (when one can get a similar but more intense effect by paying less for actually euphoric serotonergics).

So while it is likely that they'd have some kind of psychoactivity, it simply isn't worth pursuing.
 
This assumption excludes the possibility of making the triptanes oneself...which is not too far fetched, as the synth isn't extremely difficult.

It was not the question if it's worth the effort but if the triptanes possess any useful property. Plz let me decide myself if I want to pay for it or not ;)
 
Jamshyd said:
The triptan drugs are all like, what, $25/pill? I think any kind of slight benefit one gets out of them simply does not add up to the price (when one can get a similar but more intense effect by paying less for actually euphoric serotonergics).

So while it is likely that they'd have some kind of psychoactivity, it simply isn't worth pursuing.
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No kidding. My wife takes Maxalt, which is just fucking insanely priced. You know what they must be making on profit from each fucking pill?

same with my suboxone, too, but that's a different story.
 
I have taken a lot of them that have hit the market, hundreds and hundreds of times for severe, debilitating migraines, and have never had any sort of psychoactive effect from them.

Sometimes the relief from or "toning down" of extreme (EXTREME) pain will happen so quick that I get a kind of wave of relief, but I'm pretty sure its not a happy effect from the drug so much as it is me going from feeling like there is a rusty spoon being jammed in and and out of my eye socket while the light burns my retinas and the slightest movement makes me vomit in an explosive and violent manner... to having a large reduction in pain relatively quickly.

I'd probably have offed myself by now if it weren't for this class of drugs. But I have never had anything that remotely resembled a hallucinogenic, empathogenic, etc, etc type effect from any of them, at any dose I have taken.
 
i was lucky enough to get a bunch of free smaples of maxalt for my migraines even tho they are starting to get less frequent. i have never experienced anykind of euphoric effects from various triptans, but have experiences a strange feeling that i could only describe as an afterglow from MDMA. not like a euphoric feeling but a slight floaty contentment. its probably because my migraine was gone hah.
 
So, general assumption is that the major effect is the pain-relieving one, including subjective and subtle sideeffects, caused by the same reason? What a pity...
 
Could one say that its analogous to how good an anxiety sufferer feels after taking a benzodiazepine to quell an anxiety attack?
Benzos on their own aren't very euphoric (opinions differ, I'm sure), but if you have anxiety, there's nothing better.
 
My wife is in her best moods when she takes this PRIOR to a headache. Mrs. Snowbear once said, "I have never felt so good at work" after taking this in the morning.

She does not regularly take meds. maybe 1 or 2 percs and a xanax each month. She says the Percs make her tired.
 
Snowbear said:
My wife is in her best moods when she takes this PRIOR to a headache. Mrs. Snowbear once said, "I have never felt so good at work" after taking this in the morning.
Click to expand...
Now tell me what man, but this is an interesting point! I assume, you are talking about migraine headaches 'coz triptanes are not supposed to work on plain headaches. Have to ask my colleague again about this particular detail and will report later...

Murphy
 
No, they will not work on a non-migraine headache. You are supposed to take them as soon as you can when you notice a migraine is coming on. People that get them a lot can sort of pick up on this, like animals do before a storm or something. You can tell something that you can't quite put your finger on just isn't right. Sometimes (not all folks) people can see halos of sorts around point light sources, like you might on a smaller dose of a hallucinogenic drug. At that point you know you have a few minutes before you are stricken with one. Things can seem uncomfortably bright before one, as well.
 
I never experienced this with sumatriptan/rizatriptan, and even if it did produce a mild euphoria, it would be quite difficult to notice during and shortly after a migrane.
 
...and the isomers?!

Can anybody comment on the isomers of the usual triptanes, in particular the ones who have the pos.5 residue moved to pos. 4? Are they known/published and if so: With what properties?

Peace! Murphy
 
you will not get euphoria or psychactive fx other than what they are RX'd for. I've taken a whole pack(10+) of Suma before and it felt like veins in my head were heavily constricted( very odd). I was not expecting that effect but it was not pleasant
 
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