Tryptamines 5-f-met bretisilocin

[TheLightBringer]

I think this is the molecule we're talking about here https://en.wikipedia.org/wiki/Bretisilocin, 5-meo-met. Can't remember if that has turned up as an RC in the past anywhere before this patent etc. 1 billion seems like an awful lot to spend for something like this, I wonder if that figure is expanded in order to impress via shell-game bookkeeping? How could you spend that much on something like this? I get that proper drug trials and lawyers can be expensive, but that expensive?

5-Fluoro-MET, and ive seen a couple posts about it lately on reddit. Yes the 1,2 billion$ figure is quite wild at first sight. Although if you look at the history of AbbVie they have made many more billions in revenue from other patents. Its not too wild when you zoom out that they would sell the patent for Bretisilocin for 1,2 billion compared to what it could potentially generate in return, the people at gilgamesh must really believe in it which bodes well for it becoming a future medication.

 

[perpetualdawn]

@TheLightBringer oh yeah sorry I got myself mixed up there it's, 5-Fluoro-MET ! I still have a hard time believing 1.2bil is a good spend on something like this. I think viagra was meant to be about a billion to develop (given, that was quite a long time ago) and boners are probably worth a lot more than psychological therapy that a drug like this can be used for - not to mention that it will be far from having that market cornered. But hey, if therapy really is that valuable to the world market, power to them I guess!

 

[Didgital]

I think this is the molecule we're talking about here https://en.wikipedia.org/wiki/Bretisilocin, 5-meo-met. Can't remember if that has turned up as an RC in the past anywhere before this patent etc. 1 billion seems like an awful lot to spend for something like this, I wonder if that figure is expanded in order to impress via shell-game bookkeeping? How could you spend that much on something like this? I get that proper drug trials and lawyers can be expensive, but that expensive?

5-meo-MET was available. I would compare it to a longer but less intense 5-meo-dmt that had less desireable physical effects.

I am curious about 5F tryptamines, but mainly to compare to 5Br-DMT which ive tried. Cant even call that a psychedelic.

 

[perpetualdawn]

I'm a little nervous about fluorinated psychedelics, because I think a lot of fluorinated molecules can be toxic and are extremely hard to break down ("forever chemicals") - but not sure if my caution is reasonable.

 

[tuppingtoncity]

I'm a little nervous about fluorinated psychedelics, because I think a lot of fluorinated molecules can be toxic and are extremely hard to break down ("forever chemicals") - but not sure if my caution is reasonable.

There are a bunch of super common fluorinated compounds in medicinal chemistry that aren't at all toxic (e.g. prozac). I also find it hard to believe that Abbvie would blow a billion on a compound that has any inkling of acute toxicity. Def not advising use, but it's probably safe.

 

[Bagseed]

5-meo-MET was available. I would compare it to a longer but less intense 5-meo-dmt that had less desireable physical effects.

I am curious about 5F tryptamines, but mainly to compare to 5Br-DMT which ive tried. Cant even call that a psychedelic.

the atomic radius of fluorine is comparable to that of hydrogen, whereas bromine is way bulkier. My slightly educated guess would be that this matters with regards to receptor binding.

 

[Mownow]

Hey guys! First post here. I've found 5-F-MET from a certain Canadian vendor which some might say has a 'sketchy' vibe. What makes me very hesitant on trying anything is that apparently when I asked chemistry nerds, the NMR doesn't match the structure at all. I brought it to a local testing site, but unfortunately they don't have it in their data base, all they could confirm is that its not fentanyl... Attached is the provided NMR, thoughts?

https://image2url.com/r2/default/images/1774060587403-90f0b737-375a-49eb-b5c8-3c3f38e26802.png

 

[realgar]

Hey guys! First post here. I've found 5-F-MET from a certain Canadian vendor which some might say has a 'sketchy' vibe. What makes me very hesitant on trying anything is that apparently when I asked chemistry nerds, the NMR doesn't match the structure at all. I brought it to a local testing site, but unfortunately they don't have it in their data base, all they could confirm is that its not fentanyl... Attached is the provided NMR, thoughts?

https://image2url.com/r2/default/images/1774060587403-90f0b737-375a-49eb-b5c8-3c3f38e26802.png

Apparently, the solvent is DMSO-d₆, and its signals were removed from the spectrum (which is basically data manipulation; one shouldn't ever do that). I can't see anything resembling N-methyl and N-ethyl. The two adjacent methylene groups apparently don't belong to a tryptamine. From what I've seen, those signals must be closer to one another both in tryptamine free base and in hydrochloride (see https://www.chemicalbook.com/SpectrumEN_61-54-1_1HNMR.htm and https://www.chemicalbook.com/SpectrumEN_343-94-2_1HNMR.htm ).

I guess, it's more like tryptophol (see https://pmc.ncbi.nlm.nih.gov/articles/PMC10889091/ for the NMR spectrum in DMSO-d₆). The broad singlet at 4.6 ppm (1 H) can be attributed to its hydroxy group.

The indole ring system seems to have no substituents in the benzene ring, as we can see 4 multiplets and one singlet (1 proton each) in the aromatic region (6.8-7.7 ppm). So, no fluorine either.

The preliminary conclusion is: tryptophol. Definitely not an alkyltryptamine.

 

[kcrocker802]

5-meo-MET was available. I would compare it to a longer but less intense 5-meo-dmt that had less desireable physical effects.

I am curious about 5F tryptamines, but mainly to compare to 5Br-DMT which ive tried. Cant even call that a psychedelic.

According to multiple studies 5-br-dmt is not a psychedelic, but 5-cl-dmt and 5-f-dmt both are with 5-f-dmt being an order of magnitude more potent.

 

[aag]

I took it with someone, 12 mg nasally - in the forest by the river.

For the nose it was mild at first - but then the drip started and for the next 30 minutes it burned like hell in my throat. First effects appeared about 30 minutes after dosing.

The effects were weak. If someone had given me this as a mystery drug and I had to guess what it was, I'd say it’s some psychedelic benzofuran at a low dose - like 5-MAPB for example. For me it felt more empathogenic than psychedelic, though the psychedelic part was there if I actively looked for it.

No real visuals, except some differences in contrast and color saturation, and catching patterns in the shapes of trees and stuff like that.

Euphoria was definitely present, plus increased talkativeness. Overall it was nice, but all of these effects were very subtle, even though you could still feel them.

We didn’t notice any unpleasant bodyload, apart from the burning in the nose.

Maybe this substance will have more potential for me once I convert it to freebase and vape it. It might also work well as an additive to regular psychedelics - I'd expect it to boost the euphoria a bit and make the trips more enjoyable.

2 hours after ingestion I barely felt it.
3 hours after ingestion I was completely sober.

Next tests coming soon.

 

[TheLightBringer]

I took it with someone, 12 mg nasally - in the forest by the river.

For the nose it was mild at first - but then the drip started and for the next 30 minutes it burned like hell in my throat. First effects appeared about 30 minutes after dosing.

The effects were weak. If someone had given me this as a mystery drug and I had to guess what it was, I'd say it’s some psychedelic benzofuran at a low dose - like 5-MAPB for example. For me it felt more empathogenic than psychedelic, though the psychedelic part was there if I actively looked for it.

No real visuals, except some differences in contrast and color saturation, and catching patterns in the shapes of trees and stuff like that.

Euphoria was definitely present, plus increased talkativeness. Overall it was nice, but all of these effects were very subtle, even though you could still feel them.

We didn’t notice any unpleasant bodyload, apart from the burning in the nose.

Maybe this substance will have more potential for me once I convert it to freebase and vape it. It might also work well as an additive to regular psychedelics - I'd expect it to boost the euphoria a bit and make the trips more enjoyable.

2 hours after ingestion I barely felt it.
3 hours after ingestion I was completely sober.

Next tests coming soon.

How was the nausea or body load?
I suspect you would need like 50mg IN for true psychedelic effects, although Im not suggesting you make a 4x jump in dosage.

If you vaporize it you could start with 15mg and add another 5 - 10mg every 10 minutes until you reach desired effects.

 

[aag]

How was the nausea or body load?

There was no nausea and no unpleasant body load

 

[Esperighanto]

I took it with someone, 12 mg nasally - in the forest by the river.

For the nose it was mild at first - but then the drip started and for the next 30 minutes it burned like hell in my throat. First effects appeared about 30 minutes after dosing.

The effects were weak. If someone had given me this as a mystery drug and I had to guess what it was, I'd say it’s some psychedelic benzofuran at a low dose - like 5-MAPB for example. For me it felt more empathogenic than psychedelic, though the psychedelic part was there if I actively looked for it.

No real visuals, except some differences in contrast and color saturation, and catching patterns in the shapes of trees and stuff like that.

Euphoria was definitely present, plus increased talkativeness. Overall it was nice, but all of these effects were very subtle, even though you could still feel them.

We didn’t notice any unpleasant bodyload, apart from the burning in the nose.

Maybe this substance will have more potential for me once I convert it to freebase and vape it. It might also work well as an additive to regular psychedelics - I'd expect it to boost the euphoria a bit and make the trips more enjoyable.

2 hours after ingestion I barely felt it.
3 hours after ingestion I was completely sober.

Next tests coming soon.

The general theme with these 5-Fluorinated drugs seems to be that the NMR is suspect, the effects are rather weak unless vaporized, and I suspect they're a little bit of a hassle to synthesize relative to 5-MeO/5-HO/Base tryptamines (not 4-subs), but if they become easier to make I'm sure they'll become more widespread soon.

 

[xdrc]

The general theme with these 5-Fluorinated drugs seems to be that the NMR is suspect, the effects are rather weak unless vaporized, and I suspect they're a little bit of a hassle to synthesize relative to 5-MeO/5-HO/Base tryptamines (not 4-subs), but if they become easier to make I'm sure they'll become more widespread soon.

There must be at least two batches by different companies, and the false NMR is probably tryptophol, yet the compound sold by that one company seems to be psychoactive. The starting building block for those is available, and for the rest the chemistry is parallel to unsubstituted and 5-methoxylated derivatives with none of the hassles of the 4-hydroxylated. I'd still like to see independent confirmation that the batches going around are indeed 5-F-MET, but I'd be surprised if they aren't.

 

[Esperighanto]

There must be at least two batches by different companies, and the false NMR is probably tryptophol, yet the compound sold by that one company seems to be psychoactive. The starting building block for those is available, and for the rest the chemistry is parallel to unsubstituted and 5-methoxylated derivatives with none of the hassles of the 4-hydroxylated. I'd still like to see independent confirmation that the batches going around are indeed 5-F-MET, but I'd be surprised if they aren't.

I didn't consider tryptophol as being what the NMR represented but I was suspicious it was something indolic, my NMR interpretation skills are still budding. The building block for these compounds isn't just available but could probably be approached from a clandestine perspective, I could think of three routes which may be worthwhile for its creation just while typing this response. I just don't know how that fluorine is going to hold up to adding your N,N-methylethyl substitution, my grasp on molecular dynamics is way too poor at the moment to try to guess how that would go. I guess a gentle enough reduction would probably be safe and sound, idrk. What leads you to suspect that there are two separate batches going around?

 

[xdrc]

It is being sold both by a North American and a European vendor, and from my (outside) knowledge they are not connected. Any synthetic route that you could conceive for MET would work, provided you start with a building block that has a fluorine tagged onto the appropriate position. It will stay there, neither does it get substituted nor reductively cleaved by any of the 'standard' operations. I suspect it is made via the prevalent route (i.e. the one with the b-ketoamide), the fluorinated precursor for that is a regular fine chemical which is not particularly expensive.

 

[aag]

I put 11 mg of 5F-MET fumarate in a meth pipe and heated it very slowly over a candle flame. The substance didn’t burn right away - it vaporized gradually, and I carefully inhaled the smoke over the course of about a minute. At some point, it hit suddenly.

The psychedelic effects were clear and distinct. Both CEVs and OEVs were strong, impossible to miss. The peak came immediately, reaching a +++ level and lasting about a minute, after which it dropped to a stable ++.

Mentally, the effect was rather weak compared to, for example, shrooms, but visually - during the peak - fully comparable. Psychedelic audio effects turned out to be modest at this intensity. The strongest effects were felt in the body.

The smoke was unpleasant, but tolerable. Milder than with DMT.

What surprised me the most was the potency of this route of administration. Earlier, 12 mg intranasally did almost nothing, while here, after absorbing probably around 8 mg (since I didn't burn it all), the experience was of a completely different kind.

The effects started to fade after 8 minutes, after 20 minutes the decline was noticeable, and after 30 minutes only a faint afterglow remained.

Set & setting - low mood. I spontaneously decided to check whether vaporized fumarate would work at all. Despite that, after the experience, my mood clearly improved compared to before the experiment.

 

[Didgital]

I put 11 mg of 5F-MET fumarate in a meth pipe and heated it very slowly over a candle flame. The substance didn’t burn right away - it vaporized gradually, and I carefully inhaled the smoke over the course of about a minute. At some point, it hit suddenly.

The psychedelic effects were clear and distinct. Both CEVs and OEVs were strong, impossible to miss. The peak came immediately, reaching a +++ level and lasting about a minute, after which it dropped to a stable ++.

Mentally, the effect was rather weak compared to, for example, shrooms, but visually - during the peak - fully comparable. Psychedelic audio effects turned out to be modest at this intensity. The strongest effects were felt in the body.

The smoke was unpleasant, but tolerable. Milder than with DMT.

What surprised me the most was the potency of this route of administration. Earlier, 12 mg intranasally did almost nothing, while here, after absorbing probably around 8 mg (since I didn't burn it all), the experience was of a completely different kind.

The effects started to fade after 8 minutes, after 20 minutes the decline was noticeable, and after 30 minutes only a faint afterglow remained.

Set & setting - low mood. I spontaneously decided to check whether vaporized fumarate would work at all. Despite that, after the experience, my mood clearly improved compared to before the experiment.

Saw this TR on reddit.
It seems like a very interesting substance that I probably would try if given the chance.

Wondering if anyone will be able to comment on comparing to any other METs.
Also curious if anyone on BL has tried 5-F-DMT?? All I can find is this on reddit, and they are saying it's non psychedelic..


also a recent paper on 5 halo tryptamines

Neuropharmacology of halogenated DMT analogs: psychoplastogenic and antidepressant properties of 5-Br-DMT, a psychedelic derivative with low hallucinogenic potential - Molecular Psychiatry

Current first-line antidepressants, such as selective serotonin reuptake inhibitors (SSRI), often present a delayed onset of action and fail to effectively treat a large proportion of patients, leaving a gap in the treatment of mood disorders. Psychedelics have recently emerged as promising...

www.nature.com

 

[Speak Easily]

^Bretisilocin is not that great; an effective anti-depresant, though not that great. Bretisilocin isn't a recreational drug. I think that 5-F-MALT is the one that you are looking for. Though do not buy the freebase. The freebase is an extremely viscous and difficult to work with black goo. The freebase is not appropriate outside of a professional laboratory setting. You need 5-F-MALT hemitartrate.

 

[TheLightBringer]

^Bretisilocin is not that great; an effective anti-depresant, though not that great. Bretisilocin isn't a recreational drug. I think that 5-F-MALT is the one that you are looking for. Though do not buy the freebase. The freebase is an extremely viscous and difficult to work with black goo. The freebase is not appropriate outside of a professional laboratory setting. You need 5-F-MALT hemitartrate.

Interesting, do you have any personal experience with 5F-MALT, its my first time hearing about it