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5-cyanide subbed dmt ??? whats the go

L

lagger

Bluelighter
Joined
Jan 29, 2011
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370
wanted some dmt from a person who has had crystal in the past. received powder and was told this was 5-CN-DMT which is apparently stronger than DMT, weaker than 5-methoxy subbed dmt but nn-5cn-dmt gives a much cleaner experience than 5-methoxy,

im weary i mean, it has a cyanide molecule whats the go who was tried this, a lot of people have it apparently coming from byron. some hippy gave me a big spin story of it being made there because a while back some cyanide went missin around the area and cops r crackin down on the dmt and salvia and other "business mans lunch" drugs,
 
Yeah the cynanide molecule has the trippiest properties of any molecule yet discovered.

Combine cyanide with DMT and it's like game over...
 
Cyano- groups on an aromatic ring do not pose cyanide-like toxicity issues.

I have not heard of this chemical, though i'd expect it to be active. If you can confirm that the whole thing isn't a load of BS and some entirely different chemical, I would proceed with extreme caution, working up the dose from a very low level, watching carefully for toxic sideffects, and report on your findings.


I also have not ruled out the possibility that you or the people telling you about this are pulling this whole story out of your/their ass.
 
It's funny, I distinctly remember Shulgin sayin somehwere that the 5-position in the tryptamine world is analagous in every way to the 4-position in the phenethylamine world, yet where are all these 5-substituted DMT's ? There's never any reports on 5-me-dmt, or 5-ethoxy-dmt, or 5-halogenated-dmts, and 5-MeS-DMT was never followed up with anything. Like jeez, for the awesomeness of DMT and 5-meo-dmt I practially can hardly beleive there isn't more information on 5-substituted tryptamines.
 
Well, do you think 5-bromo-DMT is worth buying? Wiki claims that is hallucinogen, but doesn't have more infor about this.

For example, wiki suggests that 5-Fluoro-DMT is not very active. But 2C-F isn't active too.

5-Bromo, and 5-Chrolo substituded N,N-DMTs seem to be easily available. However they aren't present on so-called "RC scene", so I doubt they are cool.
 
But I am so fucking interested in buying something rare and unresearched, so I would buy 5-Bromo-DMT instead of something well-know and producing good effects, like 4-HO-DET, 4-HO-MiPT or DiPT.
Urgh, hopefully such tryptamines aren't costy to end-user!
 
But I am so fucking interested in buying something rare and unresearched, so I would buy 5-Bromo-DMT instead of something well-know and producing good effects, like 4-HO-DET, 4-HO-MiPT or DiPT.
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why guinea pig brand new chemicals when there are a plethora of more known yet still extremely rare chemicals to try?
 
That halide will come off under catalytic hydrogenation easy as piss, so if its proved inactive via bioassay, no harm no foul.

And correct, whilst a nitrile may liberate cyanide in vivo, a covalently bonded cyano group will not, unless it is bonded to something that can be chopped off metabolically leaving a substituted cyanide which can be further be chopped to bits and liberate HCN (such as acetonitrile can cause cyanide toxicity in case of large scale exposure)
 
5-bromo-DMT & 5,6-dibromo-DMT have been studied in at least one publication. One of my former professors is actually co-authored on that paper. And in forced swim trials with rodents, one or both of them exhibited an anti-depressant effect, so these may end up being more aMT like, but that's rampant speculation on my part.
 
It does seem odd that there are not more 4-, 5- or 7- substituted N,N-dialkyl tryptamine derivatives sold as RCs, seeing as there are actually quite a number of derivatives substituted in these positions that have been found to be active in animals or at least to be 5HT2A agonists in vitro, but yet appear to never have been tested in humans.

I'm thinking the difficulty in synthesis is the main hurdle, ring-substitution of indoles is in general significantly more challenging than on phenyl rings. But also most of these simple tryptamines that have decent 5HT2A affinity are also fairly potent agonists at 5HT1A and 5HT2C, so most likely there would be a lot of trial and error required to find the good ones, with many compounds that are active hallucinogens but are overshadowed by unpleasant side effects (4-HO-MPMI springs to mind)

5-CN-DMT is probably active, and as others have stated a cyano group covalently bonded to an aromatic ring does not have the same toxicity as cyanide (this substitution is found in citalopram for instance). But this in no way should be taken to indicate that 5-CN-DMT will not be toxic in other ways - bear in mind that extracts of 5-MeO-DMT containing plants have been used by indigenous tribes as arrow poisons for hunting!
 
Not to mention the possibility of leftover cyanide...

No thanks, not worth it - and far too vague a story!
 
It does seem odd that there are not more 4-, 5- or 7- substituted N,N-dialkyl tryptamine derivatives sold as RCs
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No, they are sold. But they are sold by real big chemical vendors offering thousands of compounds, not that small shops with only 10 half-legal compounds in stock.
 
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