5/6-APB - suprisingly different effects for different people, how to explain?

[5HToInfinity]

So this all started when I acquired a batch of 6-APB and decided to take some with two close friends and go hiking. We all took approximately 115mg of the same batch, and proceeded with our hike. Within about two hours, I was feeling a distinct euphoric lift - the roll I was expecting. My friends, however, had different reactions. One of them said he was tripping very intensely, with little to no euphoria whatsoever. He said it felt like he had taken a straight psychedelic. My other friend felt absolutely nothing besides nausea.

Ok, so this is weird I thought, maybe some inconsistency in the batch. But when I took another dose from the same batch, I had the same euphoric effect, with mild psychedelic effects. My friends didn't proceed to repeat the experiment.

After a while, I acquired some 5-APB. I turned out to be not psychedelic at all for me, and was more energetic and pushy than 6-APB. Most people seemed to agree with me on this. However, a minority of people who took this batch said they tripped BALLS from it, to my surprise. When taking the 6-APB, they reported no psychedelic effects.

This led me to think that for each person, one and only one of the two, either 6 or 5, will be trippy, while the other won't. The trouble is some people trip on the 5 and roll on the 6, while other trip on the 6 and roll on the 5. I find this very interesting considering the minute molecular difference in their structure.

Has anybody had any similar thoughts? Any ways to explain this?

 

[Solipsis]

YMMV?

Only thing I can come up with is that anything that is not very selective in action can work more or less intensely for different systems if there are different sensitivities (coming directly from fluctuating mindset and corresponding chemical balance).

However for a compound to be somewhat unpredictable, the different modes of action should all have considerable efficacy... LSD is also promiscuous pharmacologically but that doesn't mean that it can suddenly come across much more histaminergic, that aspect is just not significant enough.

But for the 6-APB compounds, it is a mix of 5-HT2A agonism (correct?) as well as mixed monoamine release...

So it could go either way, more stimulant/empathogenic or more psychedelic. Of course 'little or no effect' is always an option but seriously there are many possible explanations for that happening and it is just a possibility we have to accept.

- just a few thoughts -

 

[lexaurin]

For me both are like rolling. 5 apb was more of a sedating roll and 6apb more speedy, much more dopamine release,
The combo is orgasmic much better than either alone.:D

 

[Jesusgreen]

For me both are like rolling. 5 apb was more of a sedating roll and 6apb more speedy, much more dopamine release,
The combo is orgasmic much better than either alone.:D

^ I'm in agreement with this.

I find dosage ranges explored play a large part in how the experience pans out with these sorts of drugs. At very high doses I've found 6-APB to be quite psychedelic, I've not explored 5-APB in quite so high doses.

I've noticed that while by looking at the release values for 6-APDB and 5-APDB, showing 6-APDB's much higher affinity for dopamine release, one would expect 6-APDB and 6-APB to be more stimulating than their 5-position relatives, however many have reported the opposite.

What I've also noticed though is that in many cases this seems related to dosage, as the 5-APB on the market was for example significantly more potent by weight than 6-APB, but many people were taking the same dosages of both to make up for the lack of a dopaminergic kick at lower doses of 5-APB, and as such, actually found the reverse, that at these higher doses 5-APB was more stimulating.

I'm not sure this explains all the disparity, but certainly some of it. The rest I feel is likely due to personal chemistry as Solipsis rightfully suggested.

It's also possible that some of it is down to mislabelled products as 6-APB for one is certainly a chemical that had a notoriously sketchy start off in the market and even today there are many vendors selling things that aren't 6-APB, or mixing up 5 and 6, etc..