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4-methyl-alpha-ethylmethcathinone?

R

Repulse

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I call this 4-methyl-alpha-ethylmethcathinone, as this is basicly α-ethylmethcathinone/buphedrone with a methyl-group on the 4-position.
Or the α-ethyl homologue of 4-methylmethcathinone/mephedrone, if you like.

Quite sure this has been discussed before, but I know of no common name for it, couldn't find any topics on it, nor have I seen it available anywhere.

Wouldn't this stimulant have significant potential as a NE/DA releaser?
In terms of toxicology, could the methylated 4-position be problematic?
If not, I suspect this one could be a worthy, perhaps less toxic, and more potent replacement of 4-MMC/Mephedrone.


Feel free to post any thoughts and/or information regarding this :)
 
The name is wrong. Cathinone already possesses a methyl-group in alpha-position. Therefore 4-methyl-alpha-ethylmethcathinone would look like this:




Systematical name for your compound would be 2-(methylamino)-1-p-tolylbutan-1-one.

And why the hell do you want a more potent mephedrone? Wasn't the original crappy enough for you?

- Murphy
 
It will probably be a less potent methylmethcathinone, if anything.
 
MurphyClox said:
The name is wrong. Cathinone already possesses a methyl-group in alpha-position. Therefore 4-methyl-alpha-ethylmethcathinone would look like this:




Systematical name for your compound would be 2-(methylamino)-1-p-tolylbutan-1-one.

And why the hell do you want a more potent mephedrone? Wasn't the original crappy enough for you?

- Murphy
Click to expand...

Well, mephedrone minus 5HT effects and plus increased potency from the lengthened alpha chain will probably be alot more like what buphedrone was supposed to be...which I would like alot...

But I have a feeling 3FMP will do a decent job of that anyways.
 
N0 W4RN1NG said:
Well, mephedrone minus 5HT effects and plus increased potency from the lengthened alpha chain will probably be alot more like what buphedrone was supposed to be...which I would like alot...

But I have a feeling 3FMP will do a decent job of that anyways.
Click to expand...

This was the point, or atleast my hope. A more potent mephedrone would be good, if it was safer aswell - but I wouldn't see those two terms as something that comes along easily, more likely that one of them do.
 
Why not an amphetamine instead of a cathinone? If that was possible. It looks like remove that Oxygen and youd get a methamphetamine
 
wouldnt it be more serotogenic?
Click to expand...

I think you mean serotonergic and no, lengthening the alkyl chain makes beta ketones more dopaminergic.

It looks like remove that Oxygen and youd get a methamphetamine
Click to expand...
'

No you wouldn't. Amphetamines have a 3-carbon chain, this has 4.
 
And with a 4 carbon chain, "amphetamines" are way down in potency and recreational potential.
 
I haven't seen any evidence of (m)any great 4-carbon pea's as of yet.

While buphedrone may have a lower threshold dosage than methcathinone, it is in no way more dopaminergic or "stronger" than methcathinone at reasonable (>100 mg) dosages.

MBDB, buphedrone, and butylone all make me think of the saying, "There's methyl and ethyl, but butyl is futile."

In other words, I think that the recent trend of believing buphedrone to be stronger than methcathinone is incorrect. It most certainly was not for me.
 
oh. i thought cathinones and ephedrine just have another carbon compared to amphetamine. I lack chemistry knowledge. Wouldnt the ETHYL thing make it less potent, since ethylamphetamine is less potent than d-amp, and MDE is also less effective at releasing serotonin than MDA/MDMA?
 
From a SAR standpoint, the merits of this compound should depend on whether the 4-methyl substitution engenders greater selectivity for 5ht than 3,4-methylene dioxy for beta-ketone phenethylamines. If not, then I'd expect the proposed compound to be an unhappy medium between butylone and buphedrone.

ebola
 
3-FMC seems more like a novel stimulant with no particular euphoric nor empathogenic effects, from the few reports available.
--

So, ebola, you're hinting at the unlikely possibility of this being fairly 5ht selective, more so than with the 3,4-md ketones.. I doubt it :( Is there any data (or informed guesswork) on the 5ht properties of 4-mmc?
 
To my knowledge, the binding afifnities and propensities for monoamine release for mephedrone remain unknown. Hell, I think that this is the case for buphedrone, butylone, and ethylone too. So our speculation remains such, guided by few facts. IIRC, 4-methyl-amphetamine has a ratio of monoaminergic release of roughly 1:1:1, which is starkly less selective for serotonin than MDMA, so I don't think that we can expect much from the proposed compound (let's call it 4-methyl-buphedrone).

On the other hand, it could be the case that buphedrone's recreational potential is limited by over-selectivity for DA, so adding in just a little more norepinephrinergic and serotonergic action could improve things a bit.

ebola
 
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