4'-Methyl-A-Pyrrolidinohexiophenone toxicity?

[MDPV_Psychosis]

A small sample of this has been acquired strictly for novelty. There aren't any plans of human consumption because of the extreme rarity and reported toxicity. I can find very little by searching the net beyond what I've linked at the bottom.

I was hoping somebody could elaborate further on the toxicity of either the chemical itself or its metabolities. Maybe somebody has access to documentation or whatever that is not common or available online? Its doubtful this one has been researched any further but you never know. For harm reduction purposes it would be good to clarify risks in more detail if at all possible.

http://www.fsijournal.org/article/S0379-0738(11)00112-5/abstract
http://en.wikipedia.org/wiki/4'-Methyl-α-pyrrolidinohexiophenone

 

[sekio]

I highly doubt that the a-HPMP caused rhabdomyolysis and liver damage, the guy broke both his feet jumping from a fucking window, trauma will do that to you. Esp. the rhabdomyolysis part...
Also, there seems to have been coingestion of amyl nitrite.

The cathinone series as a whole seems to be pretty benign on the liver & muscle tissue. It's the vascular system that gets a beatdown from some compounds - e.g. mephedrone & the famous "blue knees" problems.
Pyrovalerone & MDPV show a fairly mild tox profile aside from utter psychosis with bad dosing so I see no reason simply lengthening the chain one carbon is going to suddenly turn them into tissue-destroying drugs.

Anyway metabolites of this are the "usual culprits" from cathinone SAR - 4' oxidisation to hydroxy/carboxy, metabolic reduction of the ketone, hydroxylation of the alpha-chain, hydroxylation/elimination/oxidisation of the pyrrolidine. None would be expected to be any more toxic than the parent compound, just less centrally active.