RCs 4-Methyl-α-PHP (MPHP)

[roi]

https://en.wikipedia.org/wiki/4'-Methyl-α-pyrrolidinohexiophenone

Old substance, only recently (?) appeared on the market (again?) though. Might have been around a decade ago, however I couldn't find anything on BL about it. Now it seems to be available again.

 

[Tryptamite]

In 2010 a group of researchers from the Institute of Forensic Medicine, University Hospital Jena, Germany concluded that MPHP can lead to serious poisoning with toxic liver damage and rhabdomyolysis

ooh ekk

 

[rzrbld]

ooh ekk

good find :S

 

[ButylOWNED]

The is on my vendor list but I can't find NOTHING about it. Saw that may be toxic. Anyone confirm this.

 

[bipolarbear56]

Metabolism of MPHP: http://i.imgur.com/19mjv6p.png

According to academic studies, para-methylated derivatives may cause liver failure as a sad side effect, eg. MPHP (MePHP), pyrovalerone, MPPP (MePPP) because of metabolism of these derivatives: the para-methyl functional group is metabolised by cytochrome P450 which leads to toxic metabolites.
This problem does not apply to derivates without para-methyl group as alpha-PVP, alpha-PPP and alpha-PHP. So I think there's nothing to worry about, Your liver shouldn't suffer that much : )

More information:

Peters, FT; Dragan, CA; Kauffels, A; Schwaninger, AE; Zapp, J; Bureik, M; Maurer, HH (2009). "Biotechnological synthesis of the designer drug metabolite 4'-hydroxymethyl-alpha-pyrrolidinohexanophenone in fission yeast heterologously expressing human cytochrome P450 2D6--a versatile alternative to multistep chemical synthesis". Journal of analytical toxicology 33 (4): 190–7

Sauer, C.; Hoffmann, K.; Schimmel, U.; Peters, F. T. (2011). "Acute poisoning involving the pyrrolidinophenone-type designer drug 4′-methyl-alpha-pyrrolidinohexanophenone (MPHP)". Forensic Science International 208 (1–3): e20–e25.

 

[ButylOWNED]

Thank you..