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4-isopropylamphetamine

ausser_betrieb

ausser_betrieb

Greenlighter
Joined
Oct 14, 2008
Messages
7
i was just thinking about it, BL, do you think this could be active? any ideas? bioessays? potency? or is it a stupid idea, if yes, why? tell me what you think about it!

Formula:
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Probably inactive. The isopropyl group is quite bulky...

If it's active, then it's most likely a weak DNRI.

Anyway, it would be better with a secondary amine.

Also I have a better idea: 4,alpha,n-triethyl-phenethylamine.
 
I think it could have the potential to be fairly dangerous. Looks like it might be an adrenergic, vasoconstrictor, possible MAO inhibitor, serotonergic amphetamine, etc... Either way, I doubt it would too good for the heart.
 
The N-methyl version is quite weak unless you take a heroic dose. On the third day, I had an amazing vision of a weather map on the living room wall as seen from a satellite, I cried, and I experienced all around profound emotional catharsis.

But I did not make or test the substance, so just disregard this response.
 
It actually does seem like a silly question.

I think it could have the potential to be fairly dangerous. Looks like it might be an adrenergic, vasoconstrictor, possible MAO inhibitor, serotonergic amphetamine, etc... Either way, I doubt it would too good for the heart.
Click to expand...

Why the first two? Aren't most phenethylamines that are adrenergics or vasoconstrictors generally chain substituted, not ring?

Why MAO inhibitors? The amphetamines that are MAO inhibitors (real ones, this is) have an oxygen group atom on the 4 carbon. The N-unsubstituted ones, that is.

Serotonergic amphetamine? Seems possible or even likely. I don't think the others are likely- but whenever you serotonergic drugs you have to worry about vasoconstriction it seems. I always thought it was mainly a stimulant amphetamines and tryptamine derivatives. Now we know that the dragonfly compounds can have this effect.

Where do they bind to cause this effect btw?
 
The compound is a weak MAO-inhibitor in vitro, IC50 being 12.5 µM (MAO-A!).

Refs: Neuropharmacol 1986, 25(1), p.33; Br J Pharmacol 1985, 85, p.683; Naunyn-Schmiedeberg Arch Pharm 1987, 336, p.591

Just wanted to add this to the already published data on this compound, although I don't think that the effect would be significant at recreational doses. Or not?

- Murphy
 
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a whole japatti of different hydrocarbon substitution arrangements would be possible.

my guess is that a SAR should be done that includes unsaturated analogs such as ethynyl etc.

this has sorta already been done for phenyltropanes.

What would be particularly interesting is the DA/5-HT releasing ratios.

I mean, the legal barriers would far outweigh the synthetic difficulties for this project to be performed.
 
Stop putting lipophilic shit in the 4-position of amphetamine. It increases affinity for SERT and seems to make for nasty neurotoxins.
 
These were pumas. I had to eat >20 to get the vision. The dealer said they tested green with marquis I think. Really quite a weak amp. You will now realize that thc has an (n)-pentyl at the 4 benzene position if you stare at it right.
 
The original idea behind this molecule was to make a methamphetamine from cuminaldehyde, which is found as a constituent of the essential oils of eucalyptus, myrrh, cassia, cumin and others acc'd to wikipedia based quite proudly on the bible's mention of some of these medicinal herbs.

Overall I'd say it was a success, but yeah, I spent at least $250 dollars for 2.5 days of being up and one great vision at the end (plus a really good cry).

Perhaps the primary amine would have been a wiser target.
 
I think that with the lesson that we're slowly learning from Mephedrone, we should be very weary of p-subbed amphetamines.
 
p-CA is the most well known 5HTergic neurotoxin in the literature.

But back to the OP, he had good reason why he was interested in 4-isopropylamphetamine.

He was asking not just for theoretical reasons and actually had something up his sleeve (so to speak).

What source can cuminaldehyde be found in high %

I'm assuming this compound would be quite interesting, but it is probably illegal.
 
Myrrh for one, but as cuminaldehyde isn't watched and is freely available for purchase, I couldn't understand why you would bother with an extraction.
 
yes quite right, nitroethane i believe is the one that is slightly more watched and likely to raise suspicion.
 
i dont know there was cuminaldehyd while opening this post, i had something other in mind. also, im from germany, law's a bit different from america.
 
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