4-HO-MET cross tolerating with mdma?

[thedeadlywar]

Would a classical psychedelic like 4-ho-met cross tolerate with something like mdma?

 

[Shakti]

probably not much at all, despite your recent large metocin dose.

 

[effingcustie]

i don't think it would too much sense one is a tryptamine and one a phenathylamine

 

[delta_9]

^Cross tolerance is cause by the substance's mechanism of action, not it's chemical structure.

 

[effingcustie]

Hmm.. good to know. TBH I don't really know much about the chemistry of how drugs work.

What would that mean in this case? I don't know much about how each works but I'd imagine they both involve seratonin?

 

[delta_9]

Yeah the primary action of both substances is at the serotonin receptors. There could possibly be some cross tolerance but I don't think it would be significant, probably not even noticable, especially with a one time dose.

 

[Shakti]

i dont think mdma's primary action is at serotonin receptors. It's not a 5-ht agonist, like metocin. It's a serotonin and dopamine releaser and reuptake inhibitor.

 

[Solipsis]

Indeed probably not too much.
4-HO-MET is a 5HT agonist like psilocin while MDMA is among other things a 5HT and DA releaser, a 5HT reuptake inhibitor and also part of its mechanism has to do with 5HT agonism - I think MDMA is sometimes described as an indirect 5HT agonist but not a direct one.

That means that there is a slight similarity but not all too comparable, furthermore the moa of MDMA is fairly complex and not well understood while 4-HO-MET is not even researched that much (although its quite likely not very different from psilocin).