4'-Chlorodeschloroalprazolam,

[pcplease]

CAS- 92262-72-1

 

[4DQSAR]

When the pendent aromatic has a para substitution, the resulting compounds appear to have higher affinity for the peripheral GABA receptors.

 

[pcplease]

ill have to look more into what that means.

it is apparently available somewhere, and by a search has appeared a few years ago. if good, I figure would've become popular. I would be hesitant to try because of 4'-Chlorodiazepam and Diclazepam; drastically different safety profiles.

 

[Deleted member 81238]

What do different between this and Xanax?

 

[pcplease]

this one might make you vomit blood is all

 

[izo]

If it’s active at all (because of No Substitution at the benzo Ring) it would be an antagonist or Partial agonist like this ro compound that is being sold.

 

[pcplease]

deschloroetizolam is different and has no substitutions, but this titled chem simply has the Cl moved over.


thank you 4dqsar , i relayed that to those asking me about it. plenty of fine/traditional rcs around to need such novel research

 

[4DQSAR]

Ro5-4864 is sort of the parent compound,.

But without an 8 substituent, central activity would be a surprise. Unless the image mistakenly lacks an 8 substitient. Otherwise I would expect peroperal activity to be all it is - but I'm quite happy to be proven wrong.

 

[Skorpio]

Ro5-4864 is sort of the parent compound,.

But without an 8 substituent, central activity would be a surprise. Unless the image mistakenly lacks an 8 substitient. Otherwise I would expect peroperal activity to be all it is - but I'm quite happy to be proven wrong.

TPSO agonists tend to be anxiolytic as they mobilize cholesterol transport into the mitochondria, and promote the synthesis of GABAergic neurosteroids like allopregnanolone.

 

[4DQSAR]

TPSO agonists tend to be anxiolytic as they mobilize cholesterol transport into the mitochondria, and promote the synthesis of GABAergic neurosteroids like allopregnanolone.

Ah - so someone may have come across a paper showing the compound to demonstrate anxiolytic properties in animal models? That would make some sort of sense.

But kinds of worrying that vendors don't understand their products. I mentioned elsewhere that a few rip-off sites were offering opioids with apparently crazy potencies. Yeah, turns out they are duel-target ligands. Some MOP/KOP, some MOP/NOP. I didn't detail specific compounds but the papers are there if you want them.

 

[Skorpio]

Ah - so someone may have come across a paper showing the compound to demonstrate anxiolytic properties in animal models? That would make some sort of sense.

But kinds of worrying that vendors don't understand their products. I mentioned elsewhere that a few rip-off sites were offering opioids with apparently crazy potencies. Yeah, turns out they are duel-target ligands. Some MOP/KOP, some MOP/NOP. I didn't detail specific compounds but the papers are there if you want them.

I don’t have access (via scihub) but here is one that touches on how TSPO leads to the production of neurosteroids.

Anecdotally, I am familiar with the cholesterol transport enzyme STAR protein, and how its (activating) phosphorylation leads to cholesterol import to the mitochondria and increases in corticosteroid biosynthesis.

 

[4DQSAR]

Do you have the title or such - I may be able to find it for you as I always say I can do to save your time.

 

[Skorpio]

Do you have the title or such - I may be able to find it for you as I always say I can do to save your time.

I meant to include the link. Being absentminded I guess.

Translocator Protein Ligands as Promising Therapeutic Tools for Anxiety Disorders

The Translocator protein (TSPO), formerly known as the peripheral-type benzodiazepine receptor, is an 18 kDa mitochondrial protein primarily involved in steroid biosynthesis in both peripheral and glial cells. It has been extensively reported that TSPO regulates the rate-limiting translocation...

www.eurekaselect.com

 

[4DQSAR]

I meant to include the link. Being absentminded I guess.

Translocator Protein Ligands as Promising Therapeutic Tools for Anxiety Disorders

The Translocator protein (TSPO), formerly known as the peripheral-type benzodiazepine receptor, is an 18 kDa mitochondrial protein primarily involved in steroid biosynthesis in both peripheral and glial cells. It has been extensively reported that TSPO regulates the rate-limiting translocation...

www.eurekaselect.com

Sci-Hub : {title} [{doi}]

 

[Skorpio]

Sci-Hub : {title} [{doi}]

Weird, the scihub.se mirror did me wrong on that one.

Thanks!

 

[4DQSAR]

Weird, the scihub.se mirror did me wrong on that one.

Thanks!

Wrong DOI so found by title.

 

[Skorpio]

Wrong DOI so found by title.

Ah, good work. That paper references a review on a key point and I haven’t yet tried to dig into it for the primary source, I really hope it’s not some futile citogenesis cycle.

 

[4DQSAR]

Well good luck on that one. I've learnt just how hard it is to keep up to date with new sudies.

Even something as common as oxycodone has gone from people saying that the oxymorphone metabolite isn't significant to some peopl;e suggesting it's responsible for the majority of the analgesic activity. I tested the theory with an inhibitor and for me at least, it seems the oxymorphine is significant.

 

[pcplease]

Ro5-4864 is sort of the parent compound,.

But without an 8 substituent, central activity would be a surprise. Unless the image mistakenly lacks an 8 substitient. Otherwise I would expect peroperal activity to be all it is - but I'm quite happy to be proven wrong.

the person who asked originally said "it will test as alprazolam but the chlorine is on the other ring". which confused me as to how that would test as alprazolam so I told him to ask about CAS number, full chemical name , and to clarify "so a non-thieno deschloroClotizolam" to which the source apparently said no, and provided 4-chlorodeschloroalp name and CAS.

i assume the main purpose of this is just to test as alprazolam if sent to a lab, and rip off potential bulk buyers, and CNS activity is not a concern at all

 

[4DQSAR]

the person who asked originally said "it will test as alprazolam but the chlorine is on the other ring". which confused me as to how that would test as alprazolam so I told him to ask about CAS number, full chemical name , and to clarify "so a non-thieno deschloroClotizolam" to which the source apparently said no, and provided 4-chlorodeschloroalp name and CAS.

i assume the main purpose of this is just to test as alprazolam if sent to a lab, and rip off potential bulk buyers, and CNS activity is not a concern at all

Yeah - presumtive testing likely wouldn't catch it. In fact, I'm not sure if GC-MS would catch it but NMR WOULD. That is why I always insisted on the extra cost of having both.

I've had shady suppliers offering the positional isomer of K with the -Cl at the para position. Even when I sent the NMR the response was not what I expected. They just offered it at a lower price. Given that nobody knows much about those positional isomers, we said no - but I expect SOMEONE said yes.