Page 264 of Psychedelics Encyclopedia:
Many users feel that psilocybin and psilocin in synthetic form produce a
more lucid mental state than the mushrooms; they also seem to provide more
physical energy. Mushrooms generally have longer effects and are more sedating.
I completely agree with that statement, it is a lucid and energizing trip.
psilocin:-------------compared with---------LSD:
5-HT1A--2.88................................5-HT1A--3.73
5-HT1B--2.19................................5-HT1B--4.00
5-HT1D--3.40................................5-HT1D--3.70
5-HT1E--3.03................................5-HT1E--2.62
------------ ------------
5-HT2A--2.14................................5-HT2A--3.54
5-HT2B--4.00................................5-HT2B--3.11
5-HT2C--2.52................................5-HT2C--3.11
5-HT5A--2.83................................5-HT5A--3.64
------------ ------------
5-HT6--2.82.................................5-HT6---3.75
5-HT7--2.82.................................5-HT7---3.77
D1-----3.37..................................D1------2.34
adrenal 2A--1.36........................adrenal 2A---2.93
adrenal 2B--1.57........................adrenal 2B---0.00
adrenal 2c--1.03.........................adrenal 2c---0.00
4.00=maximum affinity, 0.00=no affinity
----------------------------
I woke up at 2 in the morning to write this, because something told me I need to share this with you gals and guys, hopefully some of you also stocked up on 4-aco-dmt back in the day when it was still around for cheap. Does anyone else here still have a stock of it? Something told me back then to stock up on a bunch of this, and now I finally know why I did, finally the stuff is useful to me after all these years of hating it so much. I don't know, maybe it is still around, I have no idea...fill me in if you know of the current status to help others out. I kept mine vacuum packed and frozen, never lost any potency. I absolutely hate 4-aco-dmt but I really love 4-ho-dmt. You can never go wrong with the 4 classics: mescaline, LSD, DMT with harmine and tetrahydroharmine (ayahuasca), and 4-ho-dmt. All these other RC's and "designer" psychedelics are Frakenstein molecules to me, just very pale imitations of the real things, a waste of time and money...now this is just my opinion, but that's really how I feel about them.
Materials needed:
1) 50ml round bottom flask or large test tube & stopper or vial and screw cap
2) distilled water
3) naoh
4) nitrogen gas tank and regulator
5) 4-aco-dmt fumarate
6) corning or other variable heating mantel & thermometer
7) balloon
8) stir bar
9) vitamin C
1) 15ml very hot distilled water (boiling from a microwave is added) to a 50ml round bottom
flask with stir bar ((optional you can use a large test tube or vial in which a stir bar will fit inside, egg shaped fits well)
2) 15mg of naoh (sodium hydroxide is added) slowly to the rbf, it will want to boil up, so add slowly,
it will dissolve instantly into the hot water. The hot water is used so instant dissolvation takes place,
no waiting for crystals to dissolve.
3) allow 15 minutes to 1/2 hour for the water and naoh solution to cool back to room temperature
4) add 15mg of 4-aco-dmt fumarate to the solution
5) Fill up a balloon with nitrogen from your nitrogen tank, pinch off the bottom using any kind of
clip and set it aside
6) attach nitrogen tubing line (long clear aquarium tubing) to long slender glass tubing or straw
and insert the hollow tubing into the water in the flask, turn regulator from off to lowest setting
so that nitrogen exits the tubing slowly, insert into solution, and allow it to excrete the oxygen from
the water for several minutes, as it does this, it will push all the oxygen out of the flask or vial as well....after several minutes slowly bring bubbling n2 gas tubing up as it continues to push out all available o2, when nitrogen line at the top of flask, turn regulator up slightly so n2 is escaping a bit faster to push all available o2 out the top...
Now open the nitrogen (N2) filled balloon and place it over the flask or vial so that n2 from the balloon exerts pressure on the contents of the flask. If you were to light a bic lighter at the top of the opening to the flask or test tube before you put the balloon on, you would find there is no o2 present, and the flame would go out, this is a nice test you can do.
7) submerge flask in a hot water bath on a variable heating mantel, and bring temp to 140 degree
F, allow it to stay at this temp for exactly 1 hour, put stir bar on the whole time.
8) all the above is done in order to freebase the 4-aco-dmt fumarate, and to allow hydrolysis of the
4-aco-dmt to 4-ho-dmt to take place (base catalyzed hydrolysis) while under an inert atmosphere,
as psilocin is unstable in alkaline environments in solution under normal oxygen atmosphere (think oxidation). Under this inert atmosphere, oxidation does not take place.
9) Hydrolysis of 4-aco-dmt to 4-ho-dmt will not take place quickly unless the solution is heated in the base. Hydrolysis can take place in un-heated solution, but no body uses it because it would take an extremely long time to complete 100%. Heating the solution allows hydrolysis to proceed quickly.
10) After 1 hour, turn off heating mantel and allow solution to come back to room temp, turn off stirring, and take off n2 balloon, put cap on flask or vial, and shake, then watch as solution changes from clear color to a blue color as the now (psilocin) reacts with the oxygen in the air and water (as it dissolves o2 from the atmosphere to replace the nitrogen which has escaped).
11) Add some crushed vitamin C to the flask to neutralize the left over naoh, and make it palatable for consumption. pour into a vial with screw cap and store in freezer or fridge, it will keep for a long time as the vitamin C prevents oxidation of the psilocin in solution, I prefer to freeze it.
12) you now have 15mg of 4-ho-dmt in flask.
-----------------------------------------------------------------------------
13) The solution of naoh makes the ph around 12. The hydrolysis reaction is catalyzed by either alkaline or acidic conditions. This reaction could also be done using muriatic acid to adust the ph to 2 once the 4-aco-dmt fumarate was freebased (which could be done before hand using sodium carbonate which is a strong base, not sodium bicarbonate) Keep the temperature between 60 and 85 degree C for at least an hour. 60 to 70 degree C is sufficient, though in the student experiments on the Hydrolysis of acetylsalicylic acid the liquid is generally heated to about 85 degree C, also for at least one hour, although the author mentions that 60 to 70 degree C is sufficient.
60 degree C = 140 degree F
70 degree C = 158 degree F
85 degree C = 185 degree F
I prefer to do the experiment using a reflux condenser to re-condense most of the water vapors, and keep the N2 balloon on top the reflux condenser, having flushed the water in the rbf, rbf and reflux condenser beforehand with N2 gas. The melting point of psilocin is 173–176 °C (343–349 °F).
It helps to look at the hydrolysis of aspirin to understand the hydrolysis of 4-aco-dmt to 4-ho-dmt,
stomach acid will only convert a small percentage of it to 4-ho-dmt (perhaps less than 5%), just as
stomach acid will only convert a small percentage of acetyl-salicylic acid (aspirin) to salicyclic acid,
otherwise you would have gastric irritation/possible stomach bleeding when swallowing an aspirin.
Heat (140-185 degree F) + time (at least one hour) + dilute hcl acid (acid based hydrolysis) or + naoh
base (base hydrolysis) is needed to convert all the 4-aco-dmt to 4-ho-dmt quickly.
acetyl-salicylic acid = aspirin
salicyclic acid = parent molecule
-------------
acetyl-psilocin = psilacetin
psilocin = parent molecule
Salicylic acid is a natural analgesic present in the leaves and bark of certain plants. It is generally
unsuitable for internal use, since it is a strong gastric irritant and can cause internal bleeding. In
fact, aspirin was invented for this very reason; the acetylated molecule isn't as rough on the digestive
tract, although it does hydrolyze to some degree in the stomach (a very small percentage of it).
Hydrolysis can also take place in plain water but no body uses it because it is so incredibly slow. Heat 140 degree F + dilute acid or base = rapid hydrolysis.
search web for aspirin & Salicylic Acid ester hydrolysis for student Labs, etc.
----------------------------------------------------------------------------
I find 4-aco-dmt (just like veteran Xorkoth at BL forum) to be very sedating and it even knocks me out completely at higher doses, it lacks the magical enchantment and visuals and stimulating quality of real 4-ho-dmt...4-ho-dmt reacts just as Shulgin writes about it in TIHKAL, a very magical visual compound active at 10mg dose, 15mg dose causing objects and furniture in the room to move up and down, wave like quality, very colorful, manic, euphoric, please read the big and dandy 4-ho-dmt thread to read real 4-ho-dmt experiences when this compound was available.
I stocked up on 4-aco-dmt back in the day...never ever liked the stuff (unless you count the time I took it with low dose 25i-nbome to counteract the intense sedation of the compound)...but now I do like 4-ho-dmt quite a lot, and find it fascinating, very much like my limited 2 spaced out higher dose experiences with the remarkable panaeoleus cyanescens I took with a beautiful college girl and two of my best guy friends from college--we were all lifeguards over the summer and partied together, the best of times.
This is the same time I used to design graphical laser lighting designs for one of the best underground house clubs in the big city, and that mushroom trip helped me to advance my designs considerably, providing me telepathicaly with much needed valuable technical information.
http://www.thenook.o...ens#entry898038 The information it imparted allowed me to figure out how to combine 3 frequency generators from my computer into a single X channel, and then again 3 more frequency channels into a single Y channel, for a total of 6 frequency channels I controlled from my own written software, these 3 x channels were sent to one X galvanometer, and the other 3 combined Y channels were sent to one Y galvanometer, the laser hit the X galvo, which then bounced off the Y galvo....
....and projected onto the dance floor were an everchanging array of 4.9mw green and red laser colored complex animated immensely beautiful patterns spirographic in complexity, which I have never seen any commercial laser device match to this date, I kept and still keep my design and software secret...but I will say that I use 2 of 3-channel integrated circuit sound generators in my design...specifically the SN76488 sound IC's, which I control with simple BASIC programming. my lasers were in demand at the height of the house seen in the late 1990's (when everyone wore black and house was king at the clubs), and I had offers from many a folk to join them in opening new clubs, so long as I provided the lighting, we would go in as 3 joint owners, neverunderestimate the power of mushrooms, mescaline, dmt, or acid to enhance creativity and aid in solution to difficult technical problems, I had been stuck for about 1.5 year on a graphical issue, and that one high dose mushroom trip provided me with the answer I seeked, what a revelation.
One pattern I would project was a solid laser "line" 3 feet long that I would cause to spin 360 degrees, imagine this in the fog, it was so trippy, it was a solid plane of laser light that would spin round and round on the dance floor, it added un-told visual dimensions to the music, and people loved dancing in and around the plane of light.
Another one of the patterns for example was a large circle that would be projected onto the dance floor, the circle would be several feet in diameter, and due to the changing 6 sound frequencies, the circle would "slowly collapse" into a small 6" in diameter circle which would then expand slowly back into the several feet in diameter circle, by piping in the music from the club into my hardware, I could cause the circle to close and open with the beats of the music, other designs included hundreds of ever changing spirographic designs like you used to see on that old kids spirographic set that used clear plastic discs and pencils placed into the holes then put on paper, and the designs traced out, very similar to those except animated, and ever changing.
We used to trip out alot of college girls on the dance floor with these lasers, and it got alot of girls out there dancing their bodies off. I would hang out in the DJ booth up high and marvel at the dance floor full of beautiful women. In the fog it looked incredible, 3-D laser designs that you could dance inside and surrounded you, really trippy. There is just something about music and 3-D laser patterns moving to the music in the fog that is mystical and transcendent. In my last design I incorporated robotic stepper motors with the laser pattern to shift the pattern all around the dance floor to the music, it was mesmerizing. Art combined with club music and dancing is fun to me. I've always loved good house music and intelligent club lighting. Lighting Dimensions was my favorite magazine and my favorite book at the time was the newly discovered "LSD my problem child" by Albert Hoffman.
From Tihkal, the continuation, 4-ho-dmt phosphate ester:
Quote
DOSAGE : 10 - 20 mg, orally (as the indolol, the acetate or the phosphate)
DURATION : 3 - 6 hrs
QUALITATIVE COMMENTS : (with 6.6 mg phosphate ester, orally) "Something has started but I decide to join in a full dinner anyway. The effects develop right through the meal, with some hints of animal faces in the pork-chop bones. No movement, nothing flows, but it probably wouldn't take much effort. Another hour and I am dropping off already. The food? Somehow I doubt it. I would be completely unable to tell this from, say, 80 milligrams of MDMA except that I had a good appetite."
(with 7 mg, orally) "Basically I am not in a pleasant place -- quite neurotic -- inwardly turned -- a touch of despair -- considerable visual activity and if I were with someone I might find some sort of reinforcement. The apathy and unpleasantness is ebbing now. My mood might have been negative, and the psilocybin simply amplified everything. There was some intensification of the lights and darks around me."
(with 10 mg, orally) "Approximately forty minutes after the start, there was a flutter and a very high, stimulated feeling, and gradually things began to move very rapidly. It was astounding. When I closed my eyes I saw so many fantastically beautiful patterns, textures, colors. Everywhere I looked, eyes open, the colors were brilliant. The house looked absolutely gorgeous and nature was simply spectacular. It was a little frightening, almost too exciting, after the gentleness of other substances. I could not believe that I was doing it, and that I had the power within myself to see such beauty. I don't know how long this went on but the motion was so rapid that I felt a sort of motion sickness. Then I became quite nauseated and remained nauseated the rest of the day, until things quieted down in the evening, and then I felt absolutely wonderful."
(with 15 mg, orally) "My 'early warning system' alerted me at fifteen minutes, then all was quiet for a while. I start building up again, and I am awfully glad that I am familiar with this transition. Visual distortions. Things distract me. I can't find the cap to my pen -- must I keep writing forever? At this point I couldn't drive, let alone write, and it is just a bit more than a half hour since I took it. The furniture in my office is moving up and down. I lie down, and close my eyes. THIS is where it is at. Visuals are wild. Even with eyes open, with no visual target, there are imaginative visual effects. I imagine a dark room with a fire place going in the middle of the night, with no other inputs, and with my eyes closed I have the body image of being seated in front of that fire and I am amazed by the hallucinations and distortions I am seeing there only there is no fireplace as I am still lying in my darkened bedroom. Sort of a 2x removed hallucination. This is a night-time drug -- the day-light washes everything out. I tried but could not repeat the fireplace thing, and must be dropping rapidly. At three hours I ask if I would try some other experiment. OK, but there are some reservations. At four hours, no reservations."
(with 15 mg, orally) "As soon as I felt the chill and the alert, I lay down and closed my eyes. Indian motif. Abundant fruits, vegetables, leaves, straw, wood, vines. Very responsive sexually. Beautiful, stern, rich encounter with livingness and Indian Gods and serenity. Color and peacefulness. A couple of hours, then elaborateness dropped slightly. At this point top of temple easy, but it was a South American temple, with earth floor, straw, vines full of fruit. Familiar feeling. We are naked and we are children-adults, daring to be there, regarded benignly (stern, amused) (rising through the floor). This is one of the true ones, this plant experience.
(with 12 mg phosphate ester, intramuscularly) "This is strong. There were a lot of wild images in about two hours, and I thought that the day would never end. At about six hours I knew it would, but in fact in the evening I took 100 milligrams of seconal which allowed me to drift into a fine sleep. The next day I was fine."
(with 3 mg phosphate ester, intravenously) "The effects are immediate (in 30 seconds) and I did not have the time to build up any worry -- it was simply too fast. In about an hour I was back where I started from."
(with 12 mg phosphate ester, intravenously) "I had had eight milligrams earlier, with a very good reaction. Here, today, I feel that everything has disintegrated, and I am extremely anxious. I am very confused."
Psilocybe cubensis: (with 1.5 g, orally) "At best, some speckled patterning with my eyes closed, and in general a light intoxication. Certainly not the sparkle of LSD. Dropped quickly and felt heavy and tired, good sleep."
(with 3.5 g, orally) "Took a gram to start with, and it started in ten minutes, but not strong enough, so did the other 2.5 grams. Everything was coming at me in waves, boxing me in, the visuals were in waves and in dark earth colors, orange and brown, not the wide spectrum of acid. I was sea-sick, and vomiting helps some, and a little dope quieted the tummy. Started dropping, and everything became very good, and by midnight I was out. No hangover at all."
------------------------
People have been trying to figure out how to convert 4-aco-dmt to 4-ho-dmt for many years on the BL
forum, you can find many (about 3 threads on this).
I have an Idea of how to do this conversion of 4-aco-dmt to 4-ho-dmt without using nitrogen gas, and it involves the following, and just may be easier, etc.:
based on the student lab of acetyl-salicylic acid (aspirin) to salicyclic acid (parent molecule) by CR
Scientific on-line (google).
I will give it a go early this week, and let you know how it turns out, it is based on the acid hydrolysis of acetyl-salicylic acid( aspirin ) to salicyclic acid (parent molecule) using ph=2 like the paper does.
Acid catalyzed conversion of 4-aco-dmt fumarate to 4-ho-dmt:
1. create a ph=12 solution of naoh and distilled water in your round bottom flask or vial.
2. throw in your 15mg of 4-aco-dmt fumarate
3. quickly spin this solution for around 1 to 2 minutes (and no longer) in order to quickly freebase the 4-aco-dmt fumarate, you don't want this to go too long (to the point where it starts to turn blue) because we are trying to freebase this quickly without destroying the molecule since it is in an alkaline solution which is detrimental to psilocin if it goes on too long.
4. now it is ready to react..
5. now add drops of muriatic acid to the flask until the ph=2
6. once the solution is at ph=2, heat it at 140 degree F for 1 hour, this is an acid catalyzed hydrolysis of 4-aco-dmt to 4-ho-dmt. (psilocin is stable in acidic solutions that are hot to about 160 degree F, perhaps even hotter, unlike alkaline solutions, in which psilocin is not stable at all, esp. exposed to air).
7. once the hour is over, let it cool down, then adjust the ph of the solution to neutral by adding drops of an naoh water solution (or you can use bicarb solution) until the ph=7 or neutral, any leftover naoh in the hcl will convert to salt. now it's ready for consumption.
I will try this next week.
IMHO, The 4-ho-dmt trip is VERY similar to a pan cyan trip, where people trip hard on just 0.5 to 1.0 gram of pan cyan, which is about 60% psilocin, 20% psilocybin, and no funky baeocystin, or norbaecosytin, but some serotonin which doesn't cross bbb. Pan cyans are considered by many to be the ultimate mushroom trip, no confusion, more euphoria and laughter and much better visuals with less mind trip, very very good visuals and sound hallucinations, also no weird body or muscles or stomach cramping like with cubes, no anxiety or confusion, just really great visual and audio hallucinations, much clearer trip, and used to be the #1 selling mushroom in Amsterdam, pan cyans have taken over many areas of the s. US as they have pushed cubies aside in many areas.
----------------------
Now for the science and References, see below:
You can either do a "ph=12 base catalyzed hydrolysis under inert atmosphere" or an "acid based hydrolysis" using ph=2 muriatic acid....both require heating at 140 degree F for 1 hour for the hydrolysis to proceed.
I'll be doing the 2nd "acid catalyzed hydrolysis" tonight to see how it turns out, I don't know yet whether it will proceed without changing colors (indicating success) during the process in a normal air atmosphere, I have my doubts, but then again it could work, what worries me is the 140 degree F heat applied to the 4-aco-dmt for 1 hour under normal air atmosphere,although it is in an acidic solution (which it can tolerate fine), it's the heat I'm worried about in the air atmosphere, but I'll give it a go and see if it proceeds without changing to degradation colors, which would indicate it is rolling along properly.
I know that a few people (esp at the BL forum) have been trying without success to convert 4-aco-dmt fumarate to 4-ho-dmt, the tricky thing you have to realize is that 4-aco-dmt when thrown into a test tube of ph=12 naoh water solution, then held either under hot running water or over a heat lamp, will quickly degrade to blue colored products over the span of many minutes depending on the heat applied to the test tube, this being also in a normal air atmosphere degrades quickly, with the color change starting in with in about 3 to 4 minutes.
This blue colored product that 4-aco-dmt is converting to IS NOT PSILOCIN like some believe, and I've tested it, and it is most definately not psilocin, it is degraded 4-aco-dmt....it also degrades into blue colored products just as real psilocin does the same. What you have to do is freebase the 4-aco-dmt under nitrogen to preserve the molecule, and THEN proceed to hydrolyze it via either base catalyzed hydrolysis or acid catalyzed hydrolysis, again under nitrogen to preserve the hydrolysis conditions, there will not be any color changes if you are doing this properly, until after the 1 hour procedure is done, when the nitrogen atmosphere is lifted, and the solution is exposed to atmospheric air (and a bit of heat if you want) to start the bluing process...you can rest assured that you now have psilocin....you can also do the following:
1) The 4-HO-DMT reacts with marquis reagent with a deep olive green/brown, which developes over 10 minutes into a forest green.
2) Stimulation results from 2mg oral ingestion of the 4-HO-DMT; a state that is not unlike low dose amphetamine
References used to formulate the experiments:
------------------------------
***1960 Pharmacology paper on psilocybin and psilocin:
The Enzymic Dephosphorylation and Oxidation of Psilocybin and Pscilocin by Mammalian tissue
Homogenates" by Hrita and Weber 1960.
hxxp://www.erowid.org/references/refs_view.php?A=ShowDocPartFrame&ID=2680&DocPartID=2304
------------------------------
***Shulgin and Trout answer questions about psilocin here:
hxxp://www.lightforcenetwork.com/sites/default/files/The%20Entheogen%20Review%2C%20Volume%20VII%2C%20Number%201%20-%20Vernal%20Equinox%201998.pdf
The Entheogen Review, Volume VII, Number 1 (Vernal Equinox 1998), see pages 10 to 12. entitled
"Internet mushroom info".
------------------------------
***The hydolysis of Aspirin (Acetylsalicylic acid) to Salicylic Acid
hxxp://www.crscientific.com/article-aspirin.html
compare to the hydrolysis of acetyl-psilocin to psilocin
-------------------------------
"The Enzymic Dephosphorylation and Oxidation of Psilocybin and Pscilocin by Mammalian tissue
Homogenates" by Hrita and Weber 1960.
** Reference (very good) which shows the stability of psilocin under nitrogen conditions vs atmospheric conditions,note the stability of the molecule under inert gas, it also shows the destruction of psilocin into a degraded product which can progress quickly within 10 minutes or less in the proper conditions:
Remember that with pan cyan mushrooms, "the more you bruise", "the more you loose", these mushrooms which contain 60% psilocin, and only 20% psilocybin, and 0% baeocystin/norbaeo are the ones that are the most similar imho to pure psilocin....
the stages are (according to the paper above, and which I have confirmed over 5 times with test tube experiments on 4-aco-dmt freebase are as follows)
1) psilocin (as well as 4-aco-dmt, acetyl-psilocin) degrades into a light blue product
2) this light blue product further degrades into blue colored product
3) this blue product further degrades into a blue-green colored product
4) this blue product further degrades into a blue-black colored product
But don't forget that 4-aco-dmt also degrades into these exact same degradation products in the same time frame and under the same condtions, exposed to air in a solution of naoh water in a test tube held under running hot water or over an alcohol lamp. It is not turning into 4-ho-dmt when you do this, but rather it is self-destructing into quinone like products, just as 4-ho-dmt does the same.
You have to hydrolyze 4-aco-dmt freebase for a period of an hour under heated conditions under an N2 atmosphere for it to convert to 4-ho-dmt, and you want to make sure it is not changing colors during this time, but that it stays clear under the nitrogen, no degradation in other words, and that's what happens under inert gas, no self-destruction.
Note the following from the reference, in particular the asterick noted phrase:
From the Dept of Pharmacology paper 1960:
Quote
The disappearance of the psilocin was accompanied by the development of a blue color in the
incubation mixture when higher concentrations of psilocin and kidney homogenate were used
the development of the blue color was extremely rapid and intense, reaching a dark blue within
a matter of minutes.
The addition of KCN completely prevented the appearance of the blue color as well as the
disappearance of psilocin.
** When the reaction was carried out under a nitrogen atmosphere similar results were found as
with KCN, indicating that the degradation of psilocin by rat kidney homogenate involved an aerobic
oxidative process.
------------------------------------
------------------------------------
------------------------------------
All just a dream found on a piece of paper blowing in the wind, all of it a big fantasy novel:
Update summer 2014:
The acid catalyzed hydrolysis of 4-aco-dmt fumarate to 4-ho-dmt freebase was a success.
1.) 50ml round bottom flask submerged in a hot water bath on corning hot plate, once the water bath is at 160 degree F, it is time to begin.
2.) 1/4 cup of distilled water was heated in microwave for 1 minute, then added 200mg of naoh slowly to the water, it dissolved instantly, set this solution aside. Measure the ph, it will be ph=12 (brown on litmus paper).
3.) add 20ml of the above naoh water solution to a 50ml round bottom flask with stir bar, suspend it in the hot water bath, and let it get to temp of 160 degree F in the hot water before proceeding.
4.) add 40mg of 4-aco-dmt fumarate to the round bottom flask, begin stirring immediately and for exactly (only) 1 minute.....it will freebase almost immediately in the flask, and if you do this quickly, it will not turn into a blue-green color, this only happens if you go to 1.5 minute and beyond, the longer you wait, the darker the color goes, and the more the deterioration (loss of product)
5.) at the 1 minute mark, add about 5 drops of muriatic acid till the ph=2
6.) let the stuff spin in the hot water bath at 155 to 160 degree F for 1/2 hour
7.) at the end of 1/2 hour, let it cool down a bit and add 1/4 teaspoon of baking soda to neutralize.
8.) I then drank 7.0 ml of the solution (it had a slight salty taste) which is about 14mg of salt or whatever it comes out to in the freebase.
9.) I tripped great, 4-ho-dmt is stimulating, very very visual, and very clear heaaded, euphoric, very similar to can pyans which are 60% psilocin, 20% psilocybin, and 0% funky baeocystin/norbeo. I had amazing closed eye visuals and open eyed visuals, my breath was taken away, it was pure heaven. Also great sound hallucinations. 4-aco-dmt is very sedating and dark and not very visual to me, this stuff is just the opposite, quite stimulating and enchanting/spiritual, and extremely visual and euphoric on the body, 4-aco-dmt lacks all those traits imho (at least for me, and i've tried 4-aco-dmt countless times, and I hate it).
This worked without using a blanket of nitrogen, so long as you freebase the 4-aco-dmt fumarate very quickly, i like to do it in less than 1 minute without using nitrogen balloon, at regular air atmosphere. Then proceed with the acid catalyzed hydrolysis. This is God's own psychedelic.
--------------
In my next experiment tonight I will repeat the above acid-catalyzed hydrolysis over again, but this time use a blanket of nitrogen the whole time (a large balloon filled with nitrogen is applied to the top of the flask while it spins at max speed with the product inside, o2 is flushed out of the solution as well before putting the balloon on), and see how it comes out. There should be zero loss of product and zero color change, indicating no 4-aco-dmt degradation products formed during the initial freebasing and subsequent ph=2 muriatic acid hydrolysis for 1/2 hour at 155 degree F. I'm assuming I will have zero loss of product. I think I had about 20% loss of product with the above experiment as I waited 1.5 minutes during the freebasing, before I started adding drops of muriatic to the flask while it was all spinning. At the 1.5 minute mark, the solution starts to turn a light green-blue while it is freebasing, if you do this in about 45 seconds, and THEN start adding the muriatic drops you will probably only have about 10% or less loss of product. I am curious to see how the nitrogen blanket exp will go, and see if I can prevent any color changes (just keep it 100% clear) during the initial 45 second or so freebasing.
More proof that nitrogen gas atmosphere works wonders:
1960 Pharmacology paper on psilocybin and psilocin:The Enzymic Dephosphorylation and Oxidation of Psilocybin and Pscilocin by Mammalian tissue Homogenates" by Hrita and Weber 1960.
hxxp://www.erowid.org/references/refs_view.php?A=ShowDocPartFrame&ID=2680&DocPartID=2304
The disappearance of the psilocin was accompanied by the development of a blue color in the
incubation mixture when higher concentrations of psilocin and kidney homogenate were used
the development of the blue color was extremely rapid and intense, reaching a dark blue within
a matter of minutes.
The addition of KCN completely prevented the appearance of the blue color as well as the
disappearance of psilocin.
When the reaction was carried out under a nitrogen atmosphere similar results were found as
with KCN, indicating that the degradation of psilocin by rat kidney homogenate involved an aerobic
oxidative process.
Later at night I experimented with a higher dose (24mg range) due to tolerance of having taken the 15mg dose in the morning, I was amazed to find an even stronger trip, and I found the closed eye visuals to be identical to my past experiences with oral DMT, harmine and THH, the trip was 3 hours long, with closed eyes, at first I saw spinning geometrics which progressed into real images over time revealing in high resolution the interior of religious temples and super fancy mansions, with everything down to detail, including the people inside, it was like being taken on a journey and being shown incredible things, Later saw Aztec or Myan structures, I was thrilled to see ayahuasca style visuals, this was just as visual, and with eyes open the world was tranformed into a thing of beauty with incredible empathy. I have about 3600mg of the 4-aco-dmt fumarate left for transformation into 4-ho-dmt freebase. Later I added crushed vitamin C to my solution in the vial before storing it in the freezer. I used up all the solution allready playing with it yesterday. I look forward to the nitrogen atmosphere experiments.
I have a tank of nitrogen from a welding place that is several feet high with regulator, and it only costs about $20 to go get it refilled, but the gas in it will last forever, there is so much of it in a large tank. I am glad the n2 cartridges are available for others to use, as it would provide a very cheap alternative. Yes, when I take the stopper out of the side arm to lower the 4-aco-dmt fumarate, this will be perfect, with the giant n2 filled balloon still over the top of the flask with the spinning flask, I have some reflux tubes I can use as well to keep vapors condensed, and I could apply the balloon to the reflux tube, but at 155 degree F, there is little loss of vapor in 1/2 hour, so a reflux tube is really not necessary. I will buy some mylar foil balloons.
I will perform this next time in round bottom flask with my glass side arm adapter with stopper, and attach the n2 filled balloon to the top (reflux condenser attachment) of the side arm. I perform the exp each time with stirring applied at max "10" setting.
These CEV's lasted for hours with my eyes closed, I put on a face mask and marveled in the interior journey, many of the visuals in monochrome colors, that would have certain items inside the temples lit up in firework colors, like being in an art exhibit or museum, it was like the trip was trying to highlite certain things inside these architectural wonders, I didn't think it was possible to have visuals like this, with a whole resolution scene in high resolution monochrome color with certain items in the scene standing out in sparkling firework colored fluorescent colors, it was breathtaking. This stuff is amazing, I know it was stupid to take a much larger dose later in the evening after having just tripped wonderfully in the morning, and I'll never do it again, but I was excited to find out what an even larger dose was like after having lost perhaps 20% or more due to not using a balloon of N2 for the process, so I wanted to make up for some of the lost potency by pushing it up a bit, to see if I could push the visuals to an even higher level, and it worked very well just this time, normally I wait at least a week or 2 weeks before taking a tryptamine again.
The world with "open eyes" was transformed into a thing of beauty with long lasting afterimages when the eyes were closed. Acid needs a "schematic" I've found for revealing breath taking visuals (unless really high doses are taken for me) but this 4-ho-dmt tryptamine causes visuals to appear out of thin air, that's how strong the visual power is.
References used to formulate the experiments:
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1960 Pharmacology paper on psilocybin and psilocin: The Enzymic Dephosphorylation and Oxidation of Psilocybin and Pscilocin by Mammalian tissue Homogenates" by Hrita and Weber 1960.
hxxp://www.erowid.org/references/refs_view.php?A=ShowDocPartFrame&ID=2680&DocPartID=2304
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Shulgin and Trout answer difficult questions about psilocin here:
hxxp://www.lightforcenetwork.com/sites/default/files/The%20Entheogen%20Review%2C%20Volume%20VII%2C%20Number%201%20-%20Vernal%20Equinox%201998.pdf
The Entheogen Review, Volume VII, Number 1 (Vernal Equinox 1998), see pages 10 to 12. entitled
"Internet mushroom info".
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The hydrolysis of Aspirin (Acetyl-salicylic acid) to Salicylic Acid, organic chemistry student lab
[using ph=2 hcl acid catalyzed hydrolysis (easiest) and alternative method of ph=12 base catalyzed hydrolysis]
hxxp://www.crscientific.com/article-aspirin.html
compare to the hydrolysis of 4-aco-dmt (acetyl-psilocin) to psilocin
p.s. The way to degas liquid, is to put it under vacuum with magnetic stirring. You can see the bubbles come out of the water. After 10 minutes or so, the liquid is degassed.
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in future in dreams, using an n2 balloon, a rbf with side adapter which will have a one-hole stopper with pipet fitted to allow the dropping in of 1) 40mg of 4-aco-dmt fumarate dissolved in 2 ml of water, 2) then later the dropping in of 4 drops of muriatic acid to adjust to ph=2, then later 3)the dropping in of 1/8th teaspoon of baking soda to neutralize and bring to ph=7, then of course at the end, 100mg of crushed vitamin c is added, and the vial frozen until use. I will degas the 20ml of water solvent in the beginning using either a vacuum or simply bubbling n2 gas through the water for 3 minutes.
You are probably wondering why do this when you can grow pan cyan mushrooms in a substrate of cow dung, brown rice and vermiculite? Well, I have about 4g of this stuff from years ago, and figured I should make good use of it. It's still out there and pretty cheap. I've always liked pan cyans, and 4-ho-dmt is no different imho.
It is very important imho to add crushed vitamin C to the final vial of solution, Vitamin C is a "strong reducing agent" and it is theorized by several people, and even backed up to some extent by Shulgin (see below) that it is possible for Vitamin C to reduce any oxidized (degraded into quinone) product BACK into psilocin by it's strong chemical reducing activity. This will be explained below by Shulgin how this is possible, a rare find in the publication world, but I found it.
This would mean you wouldn't even need nitrogen gas for any of the procedure, as any degraded product get's reduced back to psilocin by the action of the vitamin C, however, I have nitrogen , so I plan to use it, and as a friend mentioned it even comes in cheap cartridges.
I can back up that claim as well, when I added 100mg of crushed vitamin C to my final solution after the 1/2 hour, which was a very light green-blue due to my loosing about 20% of the product during the freebasing, it turned BACK TO CLEAR ! instantly when the vitamin C was added, not only that, but the solution was extremely potent dosage wise, in other words, drinking 15mg of it was just like drinking 15mg of 4-ho-dmt freebase, no loss. And the product after vitamin C was added, I might add was very strong....I had hours of firework colored closed eye visuals, and amazing open eyed visuals that night, there was the normal stimulation, and all of this was with a tolerance having sampled it in the morning, my ego was even challenged for 10 to 15 minutes in the beginning it was so strong, After that 15 minutes, it was a perfect A+ euphoric and highly visual psilocin trip, so strong I could not believe it.
On the other hand, the 1ml of final ph=7 solution that I did not add vitamin C to, and did not freeze, but rather left out in an open test tube in a warm environment for several hours, had turned to a very dark inky black color after I had returned from the waterpark, it had seriously degraded in the open air with no stopper, in a hot environment....same thing happens to pan cyans, the "more you bruise", "the more you loose", the 60% psilocin they contain starts to degrade in open air after bruised with no vitamin C to protect them.
So no excuse not to put vitamin c into your final product and then store it in the freezer, as any "oxidized psilocin" (a quinone product) can actually be reduced back into psilocin by the action of the vitamin C. I spent hours researching this claim, and believe it to be true.
Here we go for starters:
The Entheogen Review Volume VII, Number I, Vernal Equinox 1998, pages 8-13, portion of publication:
The "blueing" reaction of mushrooms is a result of psilocin being converted into diquinone. Hence, the bluer the mushroom is, the less psychoactive it will be. Eating fresh mushrooms is said to be bad, as some of the psilocin is said to convert to diquinone. Effects of diquinone are said to be anticoagulant (at high doses leading to internal bleeding), and can cause tinnitus, dizziness, nervousness, and nausea. A process to get rid of diquinone is "vitamin C" treatment.
The claim is made that vitamin C, acting as an antioxidant, can "deoxidize old weak psilocin back into it's original form." An experiment is presented wherein one puts a small amount of dried mushrooms in a glass of water, and allows it to oxidize for 30 minutes (or until the mushroom turns really bluish), and then adds 100mg of powdered vitamin C to the water, mixing it in and allowing it to sit for 30 minutes. The blue-staining diquinone is said to be deoxidized back into psilocin.
I have tried this experiment and sure enough, psilocin-containing mushrooms turn white. I also tried the steam treatment, and dissolved a vitamin C tablet in the water. After a second drying, which required only a few hours on desiccant, the mushrooms returned to their natural white color, with a wood-colored cap.
A bioassay produced a much cleaner, clearer feeling, with a substantially accelerated onset. This has become my preferred method of preparation, and I encourage others to try this method for themselves and contribute their results. I would also like to know if anyone can substantiate the claims made on this web page. Are the chemical reactions occurring as the (web page) author contents? --Rhompus, NM
Reference: (3) Bocks, Sheila M. "Fungal Metabolism IV: The Oxidation of Psilocin by p-Diphenol Oxidase (Laccase), "Phytochemistry, vol. 6 (1967), 1629-1631.
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Dr. Shulgin replies: That reference #3 sounds like the winner. It has the earliest date of the four of them, and just might be the source for the others. I was totally unaware of it, and the next time I am at the med school library over in San Francisco, I will get it.
The term that I got hung up on, was diquinone. If there is really a quinone involved, there must require the introduction of a second oxygen atom. If that indeed occurs, then no simple reduction will remove it, thus making a return to psilocin most unlikely,
However, if the "diquinone" term is being used in a loose sense, it might be that the oxidation removes the two easily available hydrogen atoms, one from the 4-hydroxy group and the other from the indolic 1-position nitrogen. The result of that action would be to produce a double bond extended conjugation system of five double bonds across the two rings with the loss of aromaticity of the benzene ring. This product would certainly be highly colored but, as no C-C or C-O bonds have been formed, it's reduction back to psilocin would be quite easy. There would be any number of gentle reducing agents that could do the job. Is vitamin C an actual reducing agent, or is it just an antioxidant?
Fascinating concept. That Phytochemistry paper is essential, and just might be a treasure---SASHA.
It turns out that vitamin C is actually a strong reducing agent from all the research I've done.
"Vitamin C is a strong reducing agent, in this lab it will reduce 2,6 dichloroindophenol"
https://www.flinnsci...20954/91358.pdf
hxxps://www.flinnsci.com/media/620954/91358.pdf
Check out the molecule undergoing reduction on page 2.
Guess what else has a phenol, that's right....psilocin...Psilocin is relatively unstable in solution due to its phenolic hydroxy (-OH) group. In the presence of oxygen it readily forms bluish and dark black degradation product...but it is theorized that the strong reducing agent vitamin C can reduce this oxidized degradation product back to psilocin.
. How do you go about recovering the psilocin after the reaction?
but from what I remember the freebase is rather rare. I’ve only ever seen it as the fumurate.