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3-OH-GABA, and N-arachidonyl-dopamine HCL

B

bingalpaws

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I was hoping someone may be able to shed some light on this product that's claiming to:

"3-OH-GABA binds to the GABA A receptor site in the brain which is the same receptor site that benzodiazepines such as Xanax bind to and 3-OH-GABA has clinically shown to increase growth hormone levels. The next innovative ingredient,N-arachidonyl-dopamine, HCL binds to the cannabinoid CB1 receptor which is the same receptor stimulated by Marijuana which is known to cause relaxation and even produces a sense of euphoria. "

Propietary blend:
3-OH-GABA
N-arachidonyl-dopamine HCL
(240mg total)



(I know these are typically, well almost universally, complete garbage, but would just like some more opinions since I've never seen a formula similar to this, seems gaba's far too low, and I've got no idea how the 2nd compound would be hitting canabinoid receptors..)
 
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bingalpaws said:
HCL binds to the cannabinoid CB1 receptor which is the same receptor stimulated by Marijuana which is known to cause relaxation and even produces a sense of euphoria. " I've got no idea how the 2nd compound would be hitting canabinoid receptors..)
Click to expand...


that doesnt make sense.. i think its just marketing to make it sound more than what it is.. probably crap
 
from what i gather NADA indeed binds to CB1 but will not elicit any psychoactive effects as it binds to the site in a different manner than the standard psychoactive CB1 agonists exemplified by THC as well as it may not be metabolically stable enough to do much of any binding

if anything it may provide some mild effects seen with other CB1 agents that are NOT creating a psychoactive THC-like effect (rec-effect)
 
GABOB btw is nothing new and there is much about it you can search for

it certainly is no GHB, but for some it may seem to offer something worhtwhile
 
In that case, I'd imagine NADA's cannabinoid effect is probably more comparable to that of Tylenol'd metabolite (forgot what its called) than to THC?
 
The "arachidonic...

compound would be a "pieces -parts" approach to an "Anandamide" amide;
http://images.google.com/imgres?img...um=10&um=1&hl=en&rls=com.microsoft:en-US&sa=N
Which is the putative endogenous cannabinoid ligand. I say "pieces- parts" because that's what we call the suggestion of a "me-too" analog, you take pieces and parts of known acive molecules and stitch them together, hoping to get something as active or more active as the endogenous ligand. But this looks to me to be a bogus idea. Much better to concentrate on known cannabinoids that really work in the CNS, by increasing potency by known modifications.
 
interesting! Yeah they constantly put out new stuff that's supposedly 'psychoactive', but never seems to be!! Last one before this was the beta methoxy phenylethylamine, which the verdict seemed to be negative on.
 
Does anyone know if that N-arachidonyl- group would by hydrolysed to give dopamine & Arachidonyl?
 
Reminisant B said:
Does anyone know if that N-arachidonyl- group would by hydrolysed to give dopamine & Arachidonyl?
Click to expand...

pretty much every other fatty acid amide is effectively broken, don't suppose this one would be any different. looks to me like N-arachidonyl-dopamine would be more effective on the kidneys than the brain, but then again I don't understand the logic behind it
 
So what would happen if an active PEA was attached to the N-arachidonyl group - any ideas?

would it be a very strange pro-drug?
 
What's the point in that? Say you had N-Arachidonyl-(2C-E), it would just end up as 2C-E in your brain. I don't really see the point in doing that unless the bioavailability was increased by the Arachidonyl group............
 
^Me neither

it just occured that some part pill manufacturers are claiming on the ingredients "fatty acid derivatives" (probably an outright lie) but wondered if such pro-drugs might be valid posibility.
 
Cannabinoids are in theory fatty acid derivatives.... That's what is being said about the pill I think you're talking about.
 
Yes the Pill summer daze. (&others now)

From discussions though I highly doubt it has any form of cannabinoid in or related compound. "Fatty acid derivatives" is clearly there to mislead in some way.

Just thinking outside the box though (highly unlikely) => was wondering if e.g cathinone derivatives could be made with extremely large alkyl substitutions that would break off in vivo.
 
Reminisant B said:
Just thinking outside the box though (highly unlikely) => was wondering if e.g cathinone derivatives could be made with extremely large alkyl substitutions that would break off in vivo.
Click to expand...

not alkyl but acyl yes.
there are various other modifications but essentially these pills contain a me too formulation, commercially available cathinones and or N-phthalimido cathinones. see phase dancer neo doves work to get an idea what it is about.
Highly unlikely anyone would bother with the arachidonyl it is not very stable to oxidation for a start.
 
vecktor said:
pretty much every other fatty acid amide is effectively broken, don't suppose this one would be any different. looks to me like N-arachidonyl-dopamine would be more effective on the kidneys than the brain, but then again I don't understand the logic behind it
Click to expand...

I'm pretty sure the logic behind it is this: It's endogenous, and it's a CB1 ligand. That's all the logic they needed.
 
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