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N&PD Moderators: Skorpio | someguyontheinternet
3-Methylmethamphetamine (3-Me-MA)
- Thread starter arschloch
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simstim
Bluelighter
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I have been doing some reading today in wiki references and it appears that 4-methoxyamphetamine and 3-methoxyamphetamime are not triple releasing/reuptake inhibiting agents like MDA, MDMA, 4-MMC, 3-MMC, bk-MDMA, etc.
Apparently pMA is primarily a selective serotonin releasing agent and mMA (meta or 3-MA) is somewhat less selective for serotonin over dopamine. Also, both released less dopamine than amphetamine. (The references are in the first paragraph of the pMA article on Wikipedia).
So perhaps the 3-methoxymethamphetamine is similar. One article I read claimed 3-MeO-A was devoid of any stereotyped stimulant behaviors in laboratory animals at all.
Hopefully 3-MeMA is closer to 4-MeMA which I have seen a published journal article which claimed 4-MeMA was a balanced triple releasing agent/reuptake inhibitor similar to 4-MMC and MDMA.
What was not addressed was whether or not it was an effective MAOi (my primary concern with it so far). 4-MM was the name given to 4-MeMA by the authors to try and avoid confusion with pMMA and 4-MMC.
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Kodeisko
Bluelighter
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Hello you all, i copy paste my reddit report about 3-MMA :
So first of all i didn't used that much 3-MMC in my life, once ~7 years ago, which was what people find 3-MMC to be like, between coke and mdma, smooth and funky ego inflation with warm sociability, i used it few years ago in pills and crystal form but it was overall mild, just like a bland and less serotonergic MDMA.
I took 3-MMA with friends, drinking alcohol in the street and then in an appartment, we all began with a 100mg bomb, which seems on the edge between common and strong dose, it was somewhat reminiscent of MDMA more so than cocaine or speed, but chilled, made us very talkative but not rolly fucked up, i would say it was close to 3-FA, more serotonergic and less clearheaded, but way less rolly than 3-FEA for example, we redosed undefined amounts orally, i guess we went up to 200-250mg or maybe more as we finished the gram (6 people, some took less, some didn't redosed, i don't remember clearly).
At a certain point i felt very stoned, as if i had smoked hash (i didn't smoke anymore since years), which made me a bit paranoid and out of the moment, also gave a bit of amnesia afterward.
I think redosing isn't that interesting nor giving a cumulative effect, should stick to a high dose first (between 100 and 150mg), like with 6-APB (redosing don't do anything more, just dirtier peak and harder comedown).
Overall i felt kinda disappointed but not that much, it's not my new top stim for sure, a bit to much of amnesia imo, but i may try it again with less alcohol for example, i didn't felt any craving nor any comedown, i think i enjoyed 3-FA more when i tried it, but have to try it again also to be sure of where it stand.
Edit : my friends find it very cool, they found it closer to speed than me
So first of all i didn't used that much 3-MMC in my life, once ~7 years ago, which was what people find 3-MMC to be like, between coke and mdma, smooth and funky ego inflation with warm sociability, i used it few years ago in pills and crystal form but it was overall mild, just like a bland and less serotonergic MDMA.
I took 3-MMA with friends, drinking alcohol in the street and then in an appartment, we all began with a 100mg bomb, which seems on the edge between common and strong dose, it was somewhat reminiscent of MDMA more so than cocaine or speed, but chilled, made us very talkative but not rolly fucked up, i would say it was close to 3-FA, more serotonergic and less clearheaded, but way less rolly than 3-FEA for example, we redosed undefined amounts orally, i guess we went up to 200-250mg or maybe more as we finished the gram (6 people, some took less, some didn't redosed, i don't remember clearly).
At a certain point i felt very stoned, as if i had smoked hash (i didn't smoke anymore since years), which made me a bit paranoid and out of the moment, also gave a bit of amnesia afterward.
I think redosing isn't that interesting nor giving a cumulative effect, should stick to a high dose first (between 100 and 150mg), like with 6-APB (redosing don't do anything more, just dirtier peak and harder comedown).
Overall i felt kinda disappointed but not that much, it's not my new top stim for sure, a bit to much of amnesia imo, but i may try it again with less alcohol for example, i didn't felt any craving nor any comedown, i think i enjoyed 3-FA more when i tried it, but have to try it again also to be sure of where it stand.
Edit : my friends find it very cool, they found it closer to speed than me
Buzz Lightbeer
Bluelight Crew
I too felt kinda stoned and just off on it (I have ADHD though).
I tried oral and most of it insufflated (hurts like hell), and didn't particularly enjoy any ROA. The comedown is quite harsh too. There's some minor serotonin action (I do take daily Seroquel, which should have some impact), but not enough such that it gets fun or anything and was mostly annoying. All in all, I'd say it just lacks strength, which I found strange considering there are some very positive reports on it. I went through a gram. Disappointing.
I tried oral and most of it insufflated (hurts like hell), and didn't particularly enjoy any ROA. The comedown is quite harsh too. There's some minor serotonin action (I do take daily Seroquel, which should have some impact), but not enough such that it gets fun or anything and was mostly annoying. All in all, I'd say it just lacks strength, which I found strange considering there are some very positive reports on it. I went through a gram. Disappointing.
arrall
Bluelight Crew
Honestly sounds like a bit of a dud here. Between shipping issues and the recent bans, many of these large clearnet NL vendors are scrambling to find a 3-MMC replacement. But this one definitely ain't it.
plumbus-nine
Bluelighter
Reasonable but also 3-MMC was kind of imperfect, the comedown tachycardia was much too strong and it depleted serotonin at very low amounts, if you used threshold dosages you'd get 1h stimulation and 23h comedown. Eek. I'd even call 4-MMC somewhat cheap but it was fun at least (and I didn't dabble enough with it to really tell).
Indeed sounds like 3-MMA isn't too good. Wonder why not 4-MMA, this already tells they searched to replace 3-MMC not to find a new masterpiece. Oh yeah. I have some on the way and will report.
Xorkoth
Bluelight Crew
I had a number of 3-MMC batches, and most of them were lackluster, but the last time I had it, it was small crystals instead of powder, and good god was it good. Just amazing, extremely euphoric, not much comedown, honestly it was like everyone says 4-MMC was back in the day (I never got to try it... actually I did go through a gram but I was blacked out at the time and I don't remember it)
Buzz Lightbeer
Bluelight Crew
As for 3-MMC, there's always been a lot of shit batches around. It's the crystals that crumble super easily that are terrible. Not potent at all and very lackluster effects.
Then there are the good crystals, but years ago I could get crystals that were actually quite clear, they were fantastic.
Then there are the good crystals, but years ago I could get crystals that were actually quite clear, they were fantastic.
4-MMC is much more serotonin heavy, it's like you condense an MDMA roll into 40 minutes or something.
I don't understand why they don't just start offering 4-MEC (which is reported to be quite good) and 4-EMC. As far as I know they are still legal to make in some places.
Tryptamite
Bluelighter
I would still be very interested in trying this substance. I imagine it to be quite potent and structurally it seems fairly straightforward stimulant.
-p-TAP increases SERT activity a lot
-m-TAB increases SERT activity less.
What they BOTH have in common is providing the body with a convenient place to metabolise so duration is shorter.
There are a number of p & m substituted amphetamines that were developed as anoretics. p-Cl amphetamine, -p-Bromoamphetamibe, m-TFM ethylamphetamine and so on.
What they ALL had in common was that they either never made it to market due to neurotoxicity or they were removed from the market due to cardiotoxicity.
Sibutramine was an amphetamine derivative and got taken from the shelves for cardiotoxicity. However, it DID have 1 trick that RC chemists should learn.
Take a close look - that cyclobutane ring places the N in exactly the same position as it would be on a plain PEA thus a potent MDMA analogue would beL
Now, since subutramine is active, we know that the cycloburane's addition to the biosteric minimum does not affect binding. It's also work remembering that the beta-ketones of PEAs had the same affinity as their parents. The bk's were less potent because their LogP was lower but in this case, I presume the LogP will be higher and so the product will be more potent.
Again, it's kind of interesting,,,, but it's PEA chemistry when all said and done.
I would very much like to see research on Lorcaserin derivatives. It's known to be hallucinogenic at high doses. I bet the ring-substitution of that compound is fascinating. I really wish Sasha was still with us, I bet he would go for the MD derivative as step 1
-m-TAB increases SERT activity less.
What they BOTH have in common is providing the body with a convenient place to metabolise so duration is shorter.
There are a number of p & m substituted amphetamines that were developed as anoretics. p-Cl amphetamine, -p-Bromoamphetamibe, m-TFM ethylamphetamine and so on.
What they ALL had in common was that they either never made it to market due to neurotoxicity or they were removed from the market due to cardiotoxicity.
Sibutramine was an amphetamine derivative and got taken from the shelves for cardiotoxicity. However, it DID have 1 trick that RC chemists should learn.
Take a close look - that cyclobutane ring places the N in exactly the same position as it would be on a plain PEA thus a potent MDMA analogue would beL
Now, since subutramine is active, we know that the cycloburane's addition to the biosteric minimum does not affect binding. It's also work remembering that the beta-ketones of PEAs had the same affinity as their parents. The bk's were less potent because their LogP was lower but in this case, I presume the LogP will be higher and so the product will be more potent.
Again, it's kind of interesting,,,, but it's PEA chemistry when all said and done.
I would very much like to see research on Lorcaserin derivatives. It's known to be hallucinogenic at high doses. I bet the ring-substitution of that compound is fascinating. I really wish Sasha was still with us, I bet he would go for the MD derivative as step 1
Burn it up
Bluelighter
The information on 3-MMA in trip reports is quite consistent regarding the effects (midly serotoninergic stimulant, comparable to meth but less jittery), but not regarding the duration. Some people report intranasal effects that last less than an hour, while an IV experience compares it to half the duration of methamphetamine. In addition, some people report almost no effects via oral administration.
Can anybody with further experience with 3-MMA comment on the duration?
This substance makes me wonder if 3-MA (the amphetamine version) could also have potential, despite the fact that EU speed contaminated with 4-MA proved to be quite toxic.
Can anybody with further experience with 3-MMA comment on the duration?
This substance makes me wonder if 3-MA (the amphetamine version) could also have potential, despite the fact that EU speed contaminated with 4-MA proved to be quite toxic.
I got 2 grams of this today and signed up to comment in case it's helpful, I've as the poster above been keeping an eye on reports about this chem in my search for a meth replacement. I've been aware of Bluelight and a sometime lurker since my second to last year in high school in 2005 (shit...) but never actually contributed anything
I can't give any reliable info about dosing as I lost my point scales somewhere in the house but it looks like I must have smoked over half a gram between 10:30AM Thurs morning and 1:36AM Friday -- just found the scales under a book and they say a gram is gone from the bag, but I've spilt heaps so def smoked less than a gram
As for effects I have to concur with the consensus, feels a lot like meth with less stimulation and bruxism, mild serotonergic effects but less of a loved up feeling than if I'd consumed a similar amount of methamphet. Even tastes like good gear in the vessel, that kind of sweetish taste. Smokes well, can take a bit of heat without burning and releases decent amounts of vapour, much closer to the experience of vaping meth than say 2-FMA. I'd say the main effects last slightly longer than the half life of meth but since I usually use stimulants in binges the only way I have to judge is how long I go in between feeling like redosing. Felt much less horny than 2-FMA or meth tend to make me but still killed about 6 hours trying to jack off. I'm also a daily opiate user with a physical habit and I've been noticing some low T symptoms lately though so could be down to that. Less vasoconstriction noticed here too as I was able to get and maintain a partial erection after the first bowl session, usually stims shrink my dick to the size of an acorn
Seems to be wearing off now altho I started binging on NEP so hard to tell what's the gross NEP aftereffects and what's the 3-MMA wearing off. Grinding teeth a bit, sore back, still wide awake fried. I know this is all pretty vague and a catalogue of irresponsible behaviour but I hope it helps someone chur
I can't give any reliable info about dosing as I lost my point scales somewhere in the house but it looks like I must have smoked over half a gram between 10:30AM Thurs morning and 1:36AM Friday -- just found the scales under a book and they say a gram is gone from the bag, but I've spilt heaps so def smoked less than a gram
As for effects I have to concur with the consensus, feels a lot like meth with less stimulation and bruxism, mild serotonergic effects but less of a loved up feeling than if I'd consumed a similar amount of methamphet. Even tastes like good gear in the vessel, that kind of sweetish taste. Smokes well, can take a bit of heat without burning and releases decent amounts of vapour, much closer to the experience of vaping meth than say 2-FMA. I'd say the main effects last slightly longer than the half life of meth but since I usually use stimulants in binges the only way I have to judge is how long I go in between feeling like redosing. Felt much less horny than 2-FMA or meth tend to make me but still killed about 6 hours trying to jack off. I'm also a daily opiate user with a physical habit and I've been noticing some low T symptoms lately though so could be down to that. Less vasoconstriction noticed here too as I was able to get and maintain a partial erection after the first bowl session, usually stims shrink my dick to the size of an acorn
Seems to be wearing off now altho I started binging on NEP so hard to tell what's the gross NEP aftereffects and what's the 3-MMA wearing off. Grinding teeth a bit, sore back, still wide awake fried. I know this is all pretty vague and a catalogue of irresponsible behaviour but I hope it helps someone chur
Morbid Sea Cow
Bluelighter
Para-methylmethamphetamine perhaps?
fastandbulbous
Bluelight Crew
Not being pissy, but I decided to make some betamethoxymeth from l-ephedrine, 30 odd years ago. It is a good stim (effectively phenmetrazine, with the morpholine ring opened). Nowt like the march of technology!I've just been having an indepth read of this paper about the SAR of substituted amphetamines in relation to MAO inhibition activity.
3-methyl-n-methylamphetamine is not one of the compounds that was tested, but the tertiary anime was tested (3-methyl-N,N-dimethylamphetamine). According to the established SAR the tertiary amine should be a weaker inhibitor of MAO than the secondary or primary amine.
Therefore we could expect 3-MeMA to be a stronger MAOi than the N,N-dimethyl version. It does inhibit MAO (as does amphetamine itself), however it's nowhere near as potent as the para-alkoxy or para-halogenated substituted amphetamines.
Amphetamine inhibits MAO with an affininity of 11 uM while pMTA and pMA are in the nanomolar range (whole orders of magnitude more potent). The tertiary amine of 3-MeA inhibits MAO with an affinity of 8uM.
It looks like 3-MeMA is gonna be a more potent MAOi than amphetamine, but nowhere near the potency at inhibiting MAO as pMTA, pMA, or even AMT (or 5-Cl-AMT).
Interestingly, this study included side chain substitutions. I keep telling everybody beta-methoxy versions of 3 and 4-methylmethamphetamine are the next wave and apparently beta-methoxy sidechain substitutions do a pretty good job of abolishing MAO inhibition.
This is an excellent article
Frontiers | Amphetamine Derivatives as Monoamine Oxidase Inhibitors
Amphetamine and its derivatives exhibit a wide range of pharmacological activities, including psychostimulant, hallucinogenic, entactogenic, anorectic, or an...www.frontiersin.org
Burn it up
Bluelighter
Considering that the available information on 3-MMA is currently still quite conflicting regarding its dosage and duration, I decided to procure a small quantity of the substance to assess it personally. In order for the considerations below to to serve as reference for dosage and duration, a sample will be sent shortly to the lab for identification and quantification via GC-MS.
Please note that at the time of writing my tolerance is most probably reset to zero. I have used stimulants very sporadically in the last year, with the last experience being 6 weeks ago. Furthermore, I am currently on a daily agmatine regimen for the last 3 weeks, which should have reset to baseline any potential tolerance.
In general, based on my trials above, the dosage for 3-MMA seems to lay in between amphetamine sulphate and methamphetamine hydrochloride.
Regarding qualitative effects, 3-MMA lays again in between amphetamine and methamphetamine: it is slightly more fun and joyful than amphetamine, without reaching the hedonistic euphoria of methamphetamine. This is not a bad thing necessarily, because I sometimes feel the push of methamphetamine a little too "forced", while the euphoria of 3-MMA felt more "natural". It is worth mentioning that, while 3-MMA's effects are in the same line as amphetamine or methamphetamine, they substantially differ from the fluorinated (meth)amphetamine analogues: on one side the serotoninergic action of 3-MMA is not as strong as with 4-FA or 4-FMA, while on the other side 3-MMA it is much more recreational and enjoyable than the functional 2-FMA or 3-FMA. Physically, there is a moderate increase in body temperature and heart rate, but 3-MMA feels less taxing on the body than other amphetamines at equipotent doses.
Regarding duration, 3-MMA's effects last approximately 1h -1.5h, and some minor after-effects may still be present until the 2h mark. This short duration is possibly due to the 3-methyl group being a great starting point for its oxidation and further metabolism (unsubstituted and especially fluorinated rings are much harder for the body to cleave). Despite the duration of 3-MMA being quite short, it is not too fiendish nor has a hard comedown as one might expect. This is because the comeup and comedown are gradual and progressive and the peak holds for a while, unlike other short-lasting stimulants that go straight from coming up to coming down almost without holding the peak. Residual stimulation is also subtle, possibly owed to the fast metabolism of 3-MMA, and sleep is easy after the main effects wear off.
Please note that at the time of writing my tolerance is most probably reset to zero. I have used stimulants very sporadically in the last year, with the last experience being 6 weeks ago. Furthermore, I am currently on a daily agmatine regimen for the last 3 weeks, which should have reset to baseline any potential tolerance.
15mg insufflated: The powder is white, fluffy, and has a tendency to clump together. Upon insufflation, there is a moderate sting reminiscent of fluorinated amphetamines that fades after 10 minutes. A clear mood lift is felt, with some very slight colour enhancement and a feeling of calm, smooth and relaxed stimulation, similar to what one could feel with 4-FMA. Effects build up slowly and peak at the 30-minute mark, holding the plateau for a while until descending progressively again. These 15mg are possibly a light dose, a museum dose.
7mg vaporized: The powder melts easily and runs effortlessly on foil in a similar manner as methamphetamine, leaving no residue. The taste is not too satisfying, reminding of the slightly plasticky aftertaste of 2-FMA. Effects come immediately but without a real rush. It feels slightly uncomfortable and not too enjoyable: mild tremor in the hands, slight anxiety and scattered and racing thoughts. After the initial push, effects remain stable until they subside at the 30-minute mark. The chronology is slightly faster and more abrupt than insufflating, I didn’t particularly enjoy it.
25mg insufflated: Considerable increase in energy, motivation, and focus with splashes of euphoria. There is a clear improvement in mood and a general sense of happiness and self-confidence. A slight hint of anxiety can be perceived in the background, but it remains dormant if doing some engaging activity – it might however become more discernible if the set and setting have been disregarded. Effects last for a little over an hour, and then the return to baseline is gradual and not too painful. This dose of 25mg is possibly a medium dose.
In general, based on my trials above, the dosage for 3-MMA seems to lay in between amphetamine sulphate and methamphetamine hydrochloride.
Regarding qualitative effects, 3-MMA lays again in between amphetamine and methamphetamine: it is slightly more fun and joyful than amphetamine, without reaching the hedonistic euphoria of methamphetamine. This is not a bad thing necessarily, because I sometimes feel the push of methamphetamine a little too "forced", while the euphoria of 3-MMA felt more "natural". It is worth mentioning that, while 3-MMA's effects are in the same line as amphetamine or methamphetamine, they substantially differ from the fluorinated (meth)amphetamine analogues: on one side the serotoninergic action of 3-MMA is not as strong as with 4-FA or 4-FMA, while on the other side 3-MMA it is much more recreational and enjoyable than the functional 2-FMA or 3-FMA. Physically, there is a moderate increase in body temperature and heart rate, but 3-MMA feels less taxing on the body than other amphetamines at equipotent doses.
Regarding duration, 3-MMA's effects last approximately 1h -1.5h, and some minor after-effects may still be present until the 2h mark. This short duration is possibly due to the 3-methyl group being a great starting point for its oxidation and further metabolism (unsubstituted and especially fluorinated rings are much harder for the body to cleave). Despite the duration of 3-MMA being quite short, it is not too fiendish nor has a hard comedown as one might expect. This is because the comeup and comedown are gradual and progressive and the peak holds for a while, unlike other short-lasting stimulants that go straight from coming up to coming down almost without holding the peak. Residual stimulation is also subtle, possibly owed to the fast metabolism of 3-MMA, and sleep is easy after the main effects wear off.
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Fertile
Bluelighter
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- Mar 31, 2022
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At least the boxy can oxidize the 3-mettyl.
The 3-(pseudo) halogenas are much worse.
Always wondered how good 3,4-dimethylmethamphetamine would be. Short duration but not neurotoxic and most certainly a triple reuptake reuptake inhibitor and triple releaser,
Likely like MDMA.
The 3-(pseudo) halogenas are much worse.
Always wondered how good 3,4-dimethylmethamphetamine would be. Short duration but not neurotoxic and most certainly a triple reuptake reuptake inhibitor and triple releaser,
Likely like MDMA.
Tryptamite
Bluelighter
So how does this compare to regular methamphetamine what are the similarities and the differences how does it smoke and what is the best ROA in your opinion
Fertile
Bluelighter
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Long ago I had both 3 methyl and 4 methyl. The 3 was much more gentle than regular methamphetamine. But for me, the key thing was that the duration was much shorter.
I'm shocked that both F&B and myself were trying out these things long, long before the RC market became mainstream.
As for quality - well RC vendors will simply have gone with whoever offers them the product at the lowest price. Grisham's Law in action.
I'm shocked that both F&B and myself were trying out these things long, long before the RC market became mainstream.
As for quality - well RC vendors will simply have gone with whoever offers them the product at the lowest price. Grisham's Law in action.
norm4n
Bluelighter
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- Feb 14, 2014
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- 65
I tried 3-MeMa today. At first I took a small line of 10mg
t+5: Nothing happened, so I loaded 10mg in a pipe and vaped it. The effects were very mild. Mood was little better, more talkative, but it lacked of energy.
t+10: Snorted 30mg
t+15: Snorted another 20mg. Still nothing. Measured my pulse which was raised by 20-25 beats.
t+75: Bombed 70mg.
Besides being in good mood and talkative I had no noteworthy effects.
Since a friend had a better experience with a smaller dose I ask myself if it could be the venlafaxine (75mg daily) blocking most of the effects. I thought it has a similiar mechanism of action like meth. With meth I need a bit more than without venlafaxine but it works like it is supposed to. Last time using stims is really long ago and I don't take them regularly, so tolerance shouldn't be an issue.
Is it the venlafaxine?
Question regarding duration: Some are saying the main effects last 5 hours, other ones 1h. My friends who had a pleasurable experience said it lasted like 5-6. Why is there so many different information on the duration?
t+5: Nothing happened, so I loaded 10mg in a pipe and vaped it. The effects were very mild. Mood was little better, more talkative, but it lacked of energy.
t+10: Snorted 30mg
t+15: Snorted another 20mg. Still nothing. Measured my pulse which was raised by 20-25 beats.
t+75: Bombed 70mg.
Besides being in good mood and talkative I had no noteworthy effects.
Since a friend had a better experience with a smaller dose I ask myself if it could be the venlafaxine (75mg daily) blocking most of the effects. I thought it has a similiar mechanism of action like meth. With meth I need a bit more than without venlafaxine but it works like it is supposed to. Last time using stims is really long ago and I don't take them regularly, so tolerance shouldn't be an issue.
Is it the venlafaxine?
Question regarding duration: Some are saying the main effects last 5 hours, other ones 1h. My friends who had a pleasurable experience said it lasted like 5-6. Why is there so many different information on the duration?
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