N&PD Moderators: Skorpio
3-methylamphetamine
http://www.ncbi.nlm.nih.gov/pubmed/15677348
Based on the evidence presented in the above paper, I think it is reasonable to postulate that the meta-cresyl configuration is preferable to para-cresyl in the amphetamine-based product.
ebola?
Bluelight Crew
We are not lab animals. We are not seeking drugs that people compulsively administer most often. Thus, sometimes some 5ht efflux is nice, even if it doesn't make you want to do it over and over in a short period.
ebola
titstypedthis
Bluelighter
exactly ebola, we aren't, theoretically we are more capable of restraint than labrats
![:\](https://bluelight.org/xf/BL_Images/Orig_Emoji/wrygrin.gif "wry grin :\")
Theoretically 3-Me-amp could prove to be a better functional stim than 4-fa... or not, everything except 4-Me-amp seems to have gotten a fairly similar response..
fryingsquirrel
Bluelighter
Certainly, although this is largely offset by our greater skill at obtaining drugs as compared to rodents.
theoretically we are more capable of restraint than labrats
ebola?
Bluelight Crew
However, we already have great functional stimulants (see dexedrine). What would be ideal is a releaser (at least for my neurology) that is highly selective for DA over NE, with little or no 5ht fx. It's unclear whether it's possible to establish this profile in a releaser (all appear selective for either NE or 5ht), but we have tools that are more dopaminergically selective than 3-methyl-amp is likely to be.
ebola
titstypedthis
Bluelighter
i guess it comes down too whats cheapest
fencamfamine
Bluelighter
Doesn't the 3-methyl essentially just shorten the T1/2 without changing the activity of the drug much? I remember someone telling me that hetero-methedrone (the m-Methyl in place of p-methyl) was a vastly better drug. It wasn't someone I trusted, so I didn't take much notice, maybe they did have something worth hearing.
I would like to know what effect on dosage & duration adding a m-methyl has on the amphetamine skeleton. I know that the 3-methoxy 4-methyl analog of MDMA was quite similar but the duration was still very high indeed. It obviously needed a group to allow the body to remove the compound or metabolize it more efficiently. The plain 4-methyl analog, however, had a duration of 4 hours or so, so maybe the body just needs space to attack the 4?
