RCs 3-MAR (not 4-MAR) or 3-Methylaminorex: A rare experience

[sernyl]

About a year ago I was fortunate to try 3-Methylaminorex, which to my knowledge remains undocumented, and seems to have never been produced in bulk. I kept some notes describing the experience. TL;DR: 3-MAR feels like it acts as an enhancer of dopamine and norepinephrine-modulating stimulants, but on its own I personally found it somewhat overwhelming.

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**DAY 1:**
DOSAGE: 12 mg + 22 mg

DURATION: N/A

QUALITATIVE COMMENTS:

(with 12 mg, stacked with 30 mg Amphetamine Sulphate, oral)

The quality of amphetamine-induced stimulation is noticeably altered. The dynamics of thinking and conjuring ideas evolve from a “bouncing rubber ball in a vacuum” to “moving plasma filaments extending from the center to the inner surface of a transparent sphere.” In other words, amphetamine alone has always been “cognitive tunnel vision” in a molecule for me, but not when combined with 3-MAR.

Meandering thoughts now have less traceable direction, but there is a light and a lightness to them. Speaking of light, there seems to be more of it bouncing off my surroundings. Some kind of “serotonergic” qualia rise in waves from the back of my neck to the crown and temples, creating warmth and maybe a tension. I am surprised by how quickly I become teary-eyed at passing thoughts that normally wouldn’t make me particularly emotional.

(with 22 mg [12 + 10 mg], oral)

Roughly 10 minutes after redosing, I’m not sure if I can spot any added layers of experience. Something may have even been subtracted. I find my focus occasionally dissolving into thousand-yard stares, which I have to consciously snap out of.

30 minutes after redosing, my verbal fluency and bright spirits flare up once again. I think I might be feeling slightly stoned, not unpleasantly so, similar to how I feel when I take 4-MMC.

**DAY 2:**
DOSAGE: 150 mg total

(with 150 mg, distributed over ~12 hours of dosing, in ~10-15 mg parts, oral + insufflated)

A full day of “just another bump,” a long fiendish reach for glimpses of energetic pushes, “magic,” but nothing more.

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[Deleted member 563132]

Very interesting!!!

 

[emkee_reinvented]

4-BMAR was a ime inactive. 3-MAR active but lost Serotinergic action.
Or so it felt to you, 4-MAR sounded to me like a sort of Meth-Amphetamine.
But better, which includes Serotinergic action.

"I find my focus occasionally dissolving into thousand-yard stares,
which I have to consciously snap out of" sound s a bit Serotoninergic to me.
Especially taking in account that it changed the academic Amphetamine,
in something that reached further.

Bit weird dosing close together first time mixing with Speed.
Day 2 raising it 100 mg, not a real pure experience.
But yeah not like i could do a one drug trial atm.

At least active unlike 4-BMAR, and 3-MMA took that last 1 a bit scared.
And felt nothing, so all these RC s maybe better NL got rid of em.
To day the grand day, but they allowed Psychedelic s to stay.
Benzodiazepine s and some more. Blanketed 3 groups only.

 

[obviously_not_carl]

This is a nice and real report and consistent with my own experiences.

I went through many grams of 3-MAR (tried some of its analogues too), and the experience you describe is exactly why you should not combine amphetamine and 3-MAR.
Tried it a few times when I was on the one or other substance and thought "might enhance the experience" and took the other once, happened four times, no matter which substance came first.
Immediately took the fun out and ruined the experience.
On its own it is very euphoric and enjoyable, I like it a lot.

It feels similar if you for example combine MPH and amphetamine, it immediately takes the dopamine fun out and somehow reverts to the noradrenaline fueled "thousand yard stare" you describe.
I think 3-MAR is a reuptake inhibitor and that is why it interfers with amphetamine if taken together?
But since there is no pharmacological data about 3-MAR, I can only speculate.

Dont combine 3-MAR with amphetamine.
It ruins the experience immediately.
You are on the one or other, and snort a line of the other substance, few minutes later and you wonder if it wasnt better a bit ago.

Anyways, it is also good to take orally, but it should be a sufficient amount (imagine taking 30mg MDMA only and basing your opinion on that).
Once had 2x30mg spaced apart around 2h and it felt very much like MDMA.
The duration, snorted or orally, is 9-10 hours.

As for analogues, I liked the 4-F analogue a lot, but it builds up tolerance VERY fast (like, I used four doses in one sitting, the first hit like a brick and I was panting with nystagism full of euphoria, the second maybe 70% of the first, the third dose just a bit stimulating and the fourth was a total waste as it just made me restless and annoyed).
The 3,4-MD analogue is nice but needs more evaluation, 4-F felt in comparison more euphoric.

 

[4DQSAR]

Are you quite sure you have the correct structure?

Because we did synthesize and perform a cohort stufy on meta methyl aminorex which people frequently refer to a 3 methyl aminorex.

Obviously we did not risk cocomintent use of any other drugs or medicines but your descriptions do sound quite similar. We were concerned that just like the prototype (aminorex), it may have demonstrated 5HT2b affinity. It did. But it was a stimulant with more of an entactogen feel.

In fact we tested a few but it became apparent that the QSAR was not the same as the simple phenethylamines and ANYTHING with a methoxy group or methylenedioxy ring was really unpredictable. So quite quickly we came to the conclusion that the para methyl and meta methyl were the safest because that labile methyl group meant that the body would reliably oxidize those methyls. both demonstrated MAOI activity.

That oxidation meant that the duration of action was far shorter than aminorex or the even longer acting para fluoro aminorex.

At least consumed alone, meta methyl aminorex was about twice as active as para methyl aminorex BUT the latter was a more selective SERT ligand i.e. happy but not stimulated.

If your compund is as shown, I can only apologize for the intrustion.

 

[Smyth2]

This looks like a fascinating compound.

I checked pubchem and it appears alongside an agent that is called WV-1501 HCl salt: [5712-28-7]. Levophacetoperane shares the same precursor as this (but i think it's a different stereoisomer).

 

[4DQSAR]

This looks like a fascinating compound.

I checked pubchem and it appears alongside an agent that is called WV-1501 HCl salt: [5712-28-7]. Levophacetoperane shares the same precursor as this (but i think it's a different stereoisomer).

Whenever I see a single stereoisomer, I wonder why throwing away 75% of any yield was considered a requirement.

I DID look at levophacetoperane and the 'obvious' route while having a paper suggesting that synthesis of an intermediate compound is simple... doesn't work.

But I don't know where that 3 methyl actually is. I mean, IUPAC would describe it as the 3-methylphenyl derivative but the same idiot who took the credit for mephedrone and Benzo Fury also guessed that 4,4'-dimethylaminorex (Seratonia) would be a good plan. I couldn't quite work out why he thought adding a second chiral centre would improve things.

Quite a few sources note that 4MAR is more toxic than AR so I can only hypothezize that mephedrone was the precursor. A chiral reduction then WOULD have been important but as far as I can tell, it was the raecemate.

 

[xdrc]

3-MAR "typically" refers to the nomenclature on the oxazolidine ring, same with 4-MAR (at least these compounds are what sernyl and obviously_not_carl refer to):

3-Methylaminorex | explore | PiHKAL·info

Explore the structures and analogues of 3-Methylaminorex

isomerdesign.com

 

[obviously_not_carl]

Are you quite sure you have the correct structure?

...

If your compund is as shown, I can only apologize for the intrustion.

Yes, 2-imino-3-methyl-5-phenyloxazolidine as hydrochloride, prepared from halostachine, which in turn was prepared via several methods.

 

[4DQSAR]

3-MAR "typically" refers to the nomenclature on the oxazolidine ring, same with 4-MAR (at least these compounds are what sernyl and obviously_not_carl refer to):

3-Methylaminorex | explore | PiHKAL·info

Explore the structures and analogues of 3-Methylaminorex

isomerdesign.com

Yeah, but Serotonia was termed 4,'4-dimethylaminorex. So it's sort of unclear.

I note Isomer Design terms the compound I mentioned as '3-methylaminorex.

Well, live and learn.

Given the availability of halostachine, yep, I can think of a couple of ways to form that final ring. So whatever else, it's going to be far cheaper and easier to make than '3-methylaminorex. If it's both safe and legal, it's a good target.

I never had chance to try it but NaHNCN was the reagent used in a GDR patent I found.

 

[obviously_not_carl]

Yeah, but Serotonia was termed 4,'4-dimethylaminorex. So it's sort of unclear.

...

Given the availability of halostachine, yep, I can think of a couple of ways to form that final ring. So whatever else, it's going to be far cheaper and easier to make than '3-methylaminorex. If it's both safe and legal, it's a good target.

I never had chance to try it but NaHNCN was the reagent used in a GDR patent I found.

The 4' means, that this group is on the aromatic ring and not elsewhere.

Two methods and reagents actually.
The method you mention works on a different precursor and does not give the n-methylated product.
But see H. Wollweber for how its done in the literature.

 

[4DQSAR]

I did say upfront that often people confuse where substitutions are and if I had misunderstood, that was on me.

That's why in cases where a there is only one homocyclic ring, I employ the outdated (but to me more precise) use of ortho, meta and para, unless atropisomerism is present.

Sci-Hub. Stereospezifische Cyclisierungen α – ω‐disubstituierter Aminoäthanole. 1. Mitt.: 1‐Aryl‐3‐imino‐3H‐oxazolo‐[3,4‐a]perhydro‐pyridine und Verwandte / Archiv der Pharmazie, 1973

That's a REALLY nice find. I admit, I mistakenly assumed that a tertiary amine would be a prodrug.

Yet again, my lack of technical German lets me down. I always enjoy learning, so many thank!