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"3,4-methylenedioxy" analogue of propylhexedrine: a good idea?

StaySedated

StaySedated

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hey, i was wondering if a 3,4-methylenedioxy compound with propylhexedrine(otc benzedrex nasal inhalers) would be a good idea. propylhexedrine is very similar in structure to methamphetamine, and compared to adderall most say(including myself) that it is more euphoric and less stimulating, and some even say propylhexedrine has mild empathogen qualities on its own, so what i'm thinking is this compound would have even more empathogen/euporiant effects than mdma, but with less stimulation.

what if there was "3,4-methylenedioxypropylhexedrine", or "3,4-methylenedioxyhexahydromethamphetamine"(synonym), would it be a good empathogen. a good reason to look into this is that MDMA's parent drug methamphetamine and propylhexedrine are very similar in structure, but propylhexedrine is not actually an amphetamine so it couldn't be considered an illegal analogue because it isn't an amphetamine.

considering propylhexedrine's effects, it seems it would be a more potent serotonin releaser(as some say it has mild empathogen effects on its own) and less potent NA releaser than MDMA(as prophylhexedrine seems less stimulating than amphetamines). idk about DA release, but one could speculate that while it may be a slightly less potent DA releaser than MDMA, the synergy of more SERT and the DA it does release would create stronger empathogen and euphoric effects(the combined release of SERT and DA is said to synergize and create strong euphoria). however, idk if it would release oxytocin like MDMA, which is part of the distinct empathogen qualites of MDMA.

i think it would have MDMA like effects because the parent drugs are so similar, i'd call it MDPH or something... ;)

any thoughts on this idea?
 
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overly adrenergic effects may be a concern, as propylhexedrine has strong vasoconstrictive side effects and heart/blood pressure concerns. however, the d-isomer(like the amphetamines) does not have these problems the l-isomer does.

i'm no chemestry wiz so excuse me if this sounds stupid but what if the compound was made with d-propylhexedrine instead of racemic?

would "d-MDPH" be any better?
 
by reducing the phenyl ring to a cyclohexane you create something with a normal aliphatic acetal structure and unlike phenolic acetals (like the methylenedioxy bridge), aliphatic acetals are very unstable to water, acid and base.
you just are creating a prodrug for 1-(2-aminopropyl)cyclohexane 3,4 diol and formaldehyde, guaranteed to have completely the wrong pharmacological profile. OTOH It would probably be a pretty good antiseptic.
 
vecktor said:
by reducing the phenyl ring to a cyclohexane you create something with a normal aliphatic acetal structure and unlike phenolic acetals (like the methylenedioxy bridge), aliphatic acetals are very unstable to water, acid and base.
you just are creating a prodrug for 1-(2-aminopropyl)cyclohexane 3,4 diol and formaldehyde, guaranteed to have completely the wrong pharmacological profile. OTOH It would probably be a pretty good antiseptic.
Click to expand...

once again, im no chemestry wiz...

i'm talking about a way to produce "3,4-methdioxypropylhexedrine"or if this synonym is more descriptive: "3,4-methlyenedioxyhexahydromethamphetamine".

i don't see how a stimulant similar to the amphetamines would be "a good antiseptic"...
 
If its anything like propylhexedrine its going to be dirty and probably overly neurotoxic.
 
i actually think a 3,4-methylenedioxy compound with propylhexedrine as the parent drug would be as good if not better than MDA or MDEA. idk about MDMA, but i guess it would be just as good because they would be so similar in structure and propylhexedrine itself is better than amphetamine imo(more euphoric, mildly empathogenic on its own, not too stimulating with just the right amount of motivation), so "MDPH" as i'd call it may be the best empathogen ever if it were ever made...
 
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*however, i think it would be less psychedelic and stimulating but with more empathogen and euphoric effects. idk but i also think it would have a different kind of comedown(more like a speed comedown than a MDMA comedown).

i could also see it having more potiential for compulsive redosing and addiction.
 
There're 250 mgs of propylhexedrine in each inhaler; it's a vastly less potent compound than amphetamine, with a far higher ratio of peripheral to central effects. A 3,4-methylene-dioxy substitution would either leave the compound unworkably inactive or too adrenergic (in relation to empathogenic effects) to be viable.

ebola
 
vecktor said:
by reducing the phenyl ring to a cyclohexane you create something with a normal aliphatic acetal structure and unlike phenolic acetals (like the methylenedioxy bridge), aliphatic acetals are very unstable to water, acid and base.
you just are creating a prodrug for 1-(2-aminopropyl)cyclohexane 3,4 diol and formaldehyde, guaranteed to have completely the wrong pharmacological profile. OTOH It would probably be a pretty good antiseptic.
Click to expand...
If you didn't really understand, don't feel alone, but my simple translation to english would be back to the drawing board. I guarantee you aren't the first to think of this yet it is not something that's around.
 
StaySedated said:
once again, im no chemestry wiz...
Click to expand...
clearly :|

i'm talking about a way to produce "3,4-methdioxypropylhexedrine"or if this synonym is more descriptive: "3,4-methlyenedioxyhexahydromethamphetamine".

i don't see how a stimulant similar to the amphetamines would be "a good antiseptic"...
Click to expand...

I understand exactly what you are trying to do, but you are barking up the wrong tree. this compound is going nowhere, the compound is not stable, and as it creates formaldehyde hence probably being a good antiseptic.

People really need to understand the chemistry before designing stuff if vendors understood chemistry and pharmacology then we would not see all kinds of dangerous and useless shite appearing.

anyway don't let the rules of chemistry and physics stop you on your shuginesque quest...
 
there are many drugs that are similar to propylhexedrine, maybe some of these will work:

Cyclopentamine- http://en.wikipedia.org/wiki/Cyclopentamine

Tranylcypromine- http://en.wikipedia.org/wiki/Tranylcypromine

out of the two tranylcypromine is a phenethylamine and substituted amphetamine, is 1/10th as potent as amphetamine by weight, and is a MAOI inhibitor(is available by Rx) with slightly more preferance for MAO-a(the one that breaks down dopamine), although it also affects MAO-b.

cyclopentamine is not a phenylethylamine, but like propylhexedrine is very similar to methamphetamine in structure. it's structure is a little different from propylhexedrine and might be better as a parent drug for a 3,4-methylenedioxy substitution, but likely theres the same problem as with propylhexedrine.

i'm most interested in tranylcypromine as a parent drug out of the two. it is a phenethylamine and similar in structure to the other mentioned drugs. however, it is a MAOI so if a 3,4-methylenedioxy compound was made with this as the parent drug, there would likely be a steep dose response curve like with PMA and similar drugs(but all you'd have to do is dose small till a max safe dose is found).

this drug would be much different, the compound would come out as "3,4-methylenedioxytransphenylcyclopropan-1-amine".

if it comes out like i think, it would be a nice empathogen but more like PMA than MDMA in terms of dangers(being a MAOI).

any thoughts on this idea?
 
So could 4-mta have been. In short, this type of acute toxicity points toward poor recreational drugs, even when such drugs are used within very constrictive limits of safety.

ebola
 
i actually realized the potiential a 3,4-methylenedioxy compound with tranylcypramine as the parent drug could have other than a recreational MDMA substitute.

you see many stimulant based antidepressants on the market-welbutrin, selegiline, as well as adderall, ritalin, and dexedrine being used off label for resistant forms of depression. now tranylcypramine is an unsual substiuted amphetamine 1/10th as powerful as amphetamine by weight with MAOI effects and DA/NA releasing effects. while the the DNRA and MAOI effects of tranylcypramine synergise rather safely and effectively at theraputic doses, the NA release(like other stimulant antdepressants) leads to anxiety and other stimulant based side effects.

now tranylcypramine doesn't release serotonin- a nerotransmitter that reduces stress, anxiety, depression, and boosts the mood and creates feelings of self acceptance and empathy when released (esp. with dopamine as seem with MDMA and other empathogens). if a compound like "3,4-methylenedioxytranscypramine" was developed, the combonation of MDMA like SERT release, amphetamine like DA and NA release, and MAOI effects would create a powerful antidepressant with the anxiety of stimulant antidepressants deminished and replaced with empathogen like qualites with added SERT release. the MAOI effects would potientiate and prolong effects, but dosing would have to be considered with great caution.

so basicaly, you get a stimulant antidepressant(stimulants have shown great antidepressant effects) with the added bonus of SERT release which would add deminished anxiety caused by others(i.e. welbutrin) as well as enhanced mood and emotional opening/well being, all with the added MAOI effects that would synergize with the nerotransmitter release(although low doses should be used due to a likely sharp dose response curve with overdose leading to serotonin syndrome or stimulant psychosis).

so, this compound could be the perfect stimulant treatment for pretty much any type of depression.
 
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