3,4-Difluoroamphetamin

[ebola?]

Affinity for SERT has pretty much nothing to do with abuse potential in my opinion, though.

I think that it does in that
1. Some people are looking for novel entactogens rather than vanilla stimulants (or did you mean to imply that we should be looking at efficacy, not binding affinity, since we're looking at releasers?) and
2. Higher affinity at SERT seems to reduce compulsive self-administration in animal models (is this what you meant by "abuse potential"?).

ebola

 

[hamhurricane]

A friend was titrating up from microgram doses of 3,4-dichloroamp but he stopped his experimentation around a threshold dose due (I believe) to cautionary remarks made by myself and RZ. I have no idea if the caution was founded but it seemed like a risky experiment due to the obvious similarity to pCA.

 

[allium]

Sorry for the offtopic question, but if I ever come across neurotoxic substance, can I know it neurotoxicity from negative side effects? I mean, does neurotoxic compounds necessarily cause any sort of negative reactions?

 

[titstypedthis]

^^ sometimes it does.. sometimes it don't.

 

[/navarone/]

Most neurotoxins of this kind actually make you trip moneky balls, eg: a high dose of mdma, you'll feel the true damage the days after most probably....that's the catch. Strong releasers are especially more dangerous than reuptake inhibitors.

BTW I was thinking of 2,4-difluoroamphetamine as a better canditate. Your thoughts gentlemen?