2cb competition at 5-HT receptor

[HalcyoN-]

Hi,

I have in my possession some very pure 2-CB crystals and my friend took them (for the first time) last night at the same time as some pretty good MDMA crystals. The effect was very MDMA-like but with a bit of anxiety and panic. I was doubting his decision to branch away from ecstasy to psychedelics because he's a pretty nervous soul, so I guess that when I told him I'd not tried them and that he was the guinea pig, this probably resulted in a lot of introspection and nervousness.

However, that he got no visuals or any other effects (at 20mg) confuses me. So I was wondering if MDMA is known to out-compete 2-CB at the serotonin receptor? Should 2-CB taken some time after (if one wanted the combination)?

 

[nuke]

MDMA is a pretty piss poor 5HT2 agonist so I doubt that's the case... Perhaps the excessively serotonin released by the MDMA could have competed with 2c-b and lessened the effect, but, I don't know. I will note that I've known people to take 2c-b after MDMA and not see much in the way of visuals, and that first timers may also not get many visuals either (my first time on 2c-i at 20mg I got barely any visuals).

 

[Ham-milton]

I've taken 20mg of 2C-B without any visuals, as well. Snorted 2C-B (5mg) produced a 10-20 minute period of light visuals, but nothing spectacular.

That was my first time, though. Probably part of the reason. I wish I still had those 2C-B pills.

 

[HalcyoN-]

I don't understand, why would you have to take it on several ocassions before it starts to work its magic (or is this common knowledge about this particular class of psychedelics)?

 

[Ham-milton]

no, it's not, but it may be an individual thing.

 

[time traveler]

Dont know about you guys but everytime i have taken MDMA + 2cb it has been alice in wonderland with god doing visual DJ-ing

So if your confident your gear is A grade, i would probably put this down to a tolerance issue. If you have touched either in the previous weeks that could explain it.

 

[Ximot]

I took 12mg 2C-B and 120mg MDMA simultaneously some time ago. I'd also had a line of coke an hour before that... and it was all VERY excitingon the come-up.. until I smoked a joint (far too early, stupid to smoke one, and a fat one it was) and everything became just breathtakingly intense. Colours and swirls, just like am extra bright MDMA come-up really... and then, I got uncomfortable and sat in paranoia and self-judgment and with closed eyes (rave party setting) for hours. It wore off 3 hours later when i had an orange juice... the beers I drank before that did nothing to help. Though it may be just a time thing... but once my state of dysphoria kicked in (pretty sudden) there were no OEV whatsoever, I think. I'm pretty sure if I had taken the 2CB later the MDMA peak, it would have given me more visual enhancement even at this dose.