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2C-T-22 through 2C-T-33 (anyone read German?)

MagickalKat777

MagickalKat777

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I found an article about these chemicals but it is in German. I am curious if anyone can look at these and decide if they have any chance of activity and if so, what one might expect based on SAR.

http://bitnest.ca/external.php?id=%7DbxUgXXCBYW%25d%7D%04%05TRQ%00UI

I figure if nothing else it should make for an interesting new discussion in ADD.

Also they mention a 2C-T-21.5 - I wonder what that one is?
 
You don't have to read german to look at the figures :D 2C-T-21.5 is SCH2CH2F

Also, like other papers written by Traschel alone, there's no in vitro data, just the syntheses :(
 
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@skillet - I looked at the figures but I am not a chemistry major nor did I ever intend to be (because I would inevitably be in prison for the concoctions I would have made by now) - how does 2C-T-21.5 differ from 2C-T-21 itself? And if anyone has the time drawing up the molecules and looking at SAR may be helpful in determining 2C's post-ban. And if you read through my posts, no I'm not a vendor. I happened to stumble on this by accident.
 
2C-T-21 = S-CH2-CH2F
2C-T-21.5 = S-CH2-CHF2
2C-T-22 = S-CH2-CF3

The fluorines are always on the second carbon from the sulfur

I wonder how this even got published without any pharmacological data, the chemistry is rather pedestrian
 
hah, i've been re-reading my (well-worn) copy of PiHKAL lately. 2ct-21 1/2 is referred to jokingly by Sasha in one of the commentaries behind another 2ct-twentysomething. should be in one of the pihkal listings hosted publicly on erowid. Have to recommend any serious researchers buy a copy for off-line (read: keep it in the throneroom) use. the (fictional?? -yeah right) narrative that comprise the first half of the book are a real gem, and have made me realize what an important figure Shulgin was/is for modern humans beyond just the chemistry. plus the old man could use the funds, i hear. respect.
 
that's a good point about the chemistry behind these being not exactly ground-breaking. haven't read it but i'm guessing it's basically the same phenol to aldehyde to nitrostyrene standard business practice? wonder if it's not the pure so much as the applied chemistry that has the editors jumpin. a nice human piece for the holidays. in this scene, nothing would surprise me. wonders never cease.
 
Thanks cortex, I misread, I'll edit it.

I've wondered where/how/why he does this stuff too, is it a university? Is he hoping to get the compounds assayed? I know he worked with Nichols on some of the 4-aryl substituted ones, but I've seen no follow up on the 2C-YN paper.
 
I was hoping this might generate some more interesting conversation - I'm imagining that most of them are inactive compounds but there have been many surprises in the research chemical world.
 
MagickalKat777 said:
I was hoping this might generate some more interesting conversation - I'm imagining that most of them are inactive compounds but there have been many surprises in the research chemical world.
Click to expand...

Even if they're all inactive on their own they could still potentiate other psyches; I know this is an often long-held tradition for the near-inactive-on-their-own substances. =D
 
Captain.Heroin said:
Even if they're all inactive on their own they could still potentiate other psyches; I know this is an often long-held tradition for the near-inactive-on-their-own substances. =D
Click to expand...

Mind elaborating on which ones? I was not really aware of this. (I have not used many psychs)
 
FlippingTop said:
Mind elaborating on which ones? I was not really aware of this. (I have not used many psychs)
Click to expand...

Ditto - except on the experience. I know of only 2C-D as being the "universal" potentiator... if we have something new that potentiates like that one we have hit an absolute gold mine....
 
There's a little bit about potentiation in pihkal, one with TMPEA potentiating mescaline, one with N-methyl-DOB and psilocybin, and TOMSO, which apparently does nothing unless you drink alcohol.
 
shulgin talks about piggy backing an inactive compound with an active compound quite a bit in pihkal. can't remember exactly which commentaries he discusses it in though.

look the the inactive MDxx analogues in pihkal
 
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He has never been that specific though and what is the reasoning that 22-33 wouldn't be active? Looking at their structures I would imagine 22-25 to be active BUT (HUGE but here) - very low potency and not very interesting IMO. The rest I can't say anything about.
 
If the previously establsihed SAR is anything to go by then I would expect 21.5 and 22 to be equal to 21 in potency. 19 and 28 are probably active as well but longer chains and phenyl/benzyl substituents turn the compounds into antagonists (but still with high affinity). The unsaturated compounds 3 and 16 could also be active, but it depends on how fast they are metabolized.
 
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