2c-i vs Mescaline (Meds causing inhibion)

[Ph0r.W3-R-m4ny]

I'm starting here because, well, this is were all the brains on BL are =p

Anyway, I've got a girl friend on these meds -
wellbutrin sr
abilify
sapharis
provigil
klonopin
levothyroxine



She seems to be able to trip on acid, shrooms work, 5-meo-dmt, MDMA, Methylone, Mephedrone, and ketamine all work fine. BUT- she seems immune to 2c's? 2cE and 2cI have hardly any effect on her (2ce works more so than 2ci- ci was hardly anything, but felt NOTHING like what she should have felt on 2ce either, though more than the ci). We both took 40mg 2ci the other day and even though I'm damn near twice her size, I was the giggling retard and she felt barely a thing. She has similar experiences with 2ce.

I want to take mescaline with her but I'm worried it might not work..

Alright all you super-drug-nerds, what do you think? I have a feeling mesc will work, buuut I'm not sure. All the phens that do work with with her have stuff sticking off the 3 or 4 positions, while 2ci and 2ce has things in 2 and 5 positions. Mescaline has groups in the 3,4, and 5 positions...

shit~ I need to finish organic lol


Anyway, the levothyroxine she is on is a thyroid med, so I could maybe see that fucking up a 2cI trip maayyybe cause of the iodine... I dunno

HELP! hehe Thanks in advance for the help guys. I don't know where to start with this one, but I would really like to have a mescaline journey with her.

*HUGZ* Thanks All!

 

[apsig]

The iodine in 2C-I is highly unlikely to interact with the levothyroxine, as the Iodine will not be cleaved from the benzene ring in vivo.

The abilify and saphris are what I would finger as the cause here, as they block 5HT-2A, the receptor traditionally associated with the actions of "classical" psychedelics.

The whole idea of "phens with things in the 3 or 4 positions work" idea is not quite applicable to psychedelics in this case, as the phenethylamines you've mentioned are not 5HT-2A agonists (at least that's not how they derive the majority of their effects). These chemicals are largely based on serotonin release (at least this is what we assume about methylone due to its similarity to MDMA in structure and effects) due to SERT binding.

Mescaline, however, acts on 5HT-2A, and could potentially be thwarted by the presence of the abilify and saphris.

It seems like this is a tryptamine/phenethylamine issue here. The psychedelics that you say work are both tryptamines, while the ones that don't are phenethylamines. I would guess that something about the difference in receptor conformations between the two families allows tryptamines to bind to the receptor in the presence of the abilify/saphris.

Sadly, as mescaline binds more weakly to 5HT-2A than the 2Cs you mentioned, my guess is that it would be similarly ineffective. Abilify has a long half life (672 hours), so it would have to be stopped for over a week to allow it to clear from the body. Saphris has a 24 hour half life, so at least a few days would be required to get it down to levels that wouldn't interfere.

May I ask what the reason for the administration of so many psychotropic drugs is? My gut reaction is that perhaps someone prescribed such a cocktail of psychotropic medication should not be using so many other substances freely, but perhaps I am overly cautious...



*I will also add that in my personal experience, abilify does not affect the potency of 2Cs to any appreciable degree.

 

[Ph0r.W3-R-m4ny]

May I ask what the reason for the administration of so many psychotropic drugs is? My gut reaction is that perhaps someone prescribed such a cocktail of psychotropic medication should not be using so many other substances freely, but perhaps I am overly cautious...

The reason is a long time of being in the system I guess you could say.. one thing to counter the side effects of the other in the long run, ya know?

I was really hoping she could feel the full effects mescaline, as I personally believe it can help a lot more in the long run than the western cook ups that are taken every day.

I was thinking a tryp / phen issue too but MDMA and shrooms/ DMT work fully soooo I dunno lol

Thank you very much apsig. Anyone else? Please keep dropping in =)

 

[sekio]

If she is on that mnany meds she shouldn't be taking psychedelics. Sorry.

Edit: Mescaline will probably not work.

 

[FlippingTop]

If she is on that mnany meds she shouldn't be taking psychedelics. Sorry.

I would probably say any drugs...

Shes taking an anti depressant, an anti psycotic/bi-polar drug, and modafinil for god knows what reason (I hope it isnt narcolepsy).

Maybe if she wasn't taking so many 'drugs' she wouldn't need to take so many drugs.

Not even considering dangerous combinations.

How old is she?



As for your question, I don't know

 

[NeighborhoodThreat]

With her current cocktail of drugs, I wouldn't recommend taking any psychedelics at all.

I can't answer your question either, but I wouldn't keep trying to take the 2C's to make it "punch through".

 

[apsig]

Like I said, MDMA is a phenethylamine, but it has a totally different target protein than the psychedelics mentioned, while shrooms and DMT are tryptamine-based. Who knows, though, just a shot in the dark. It could be possible that the indole ring somehow allows the antipsychotics to be displaced from the receptor, but this is just speculation.

When you say "a long time of being in the system" does that mean she is on these meds to counteract the negative effects of past drug use? If this is the case then she certainly shouldn't be using anything else. Some people's brains simply aren't meant for drug use...

 

[Ph0r.W3-R-m4ny]

^She's very stable everyone. (Yeah, that sounds weird, but whatever she's on, it makes her a WHOLE HELL of a lot more mentally stable than any other girl I've ever had a relationship with so take that for what it's worth lol) What I meant by saying a long time in the system is that they have her on extra meds to counteract CURRENT (Rx'd) drug use. You show up with one problem, they put you one drug, but the side effects of that lead to another drug, then another.. Like the prime example here being the provigil (FlippingTop) You mentioned narcolepsy, hell no, they put her on THAT just to keep her awake on all the other shit!

Maybe if she wasn't taking so many 'drugs' she wouldn't need to take so many drugs.

Agreed to a degree...(or completely if you're going for the drugs to counteract side effects thing- if you are implying that her 'illicit' use in any way is leading to her need for RX'd meds, you are far off base, the meds came first- and the recreational use is at a minimum I'm sure most of us wish we could achieve lol). This question wasn't asked to see if someone could 'get high', obviously she can catch a buzz of some sorts off the 2c's... anyway, what I was interested in is a single use taken in a very safe and therapeutic setting. Mescaline is good medicine, in a comfortable setting issues can be resolved and some need for a mountain of pills possibly reduced in the right circumstances. (And she is 23)

NeighborhoodThreat- that was never the idea- that day I added more to our doses to boost it at the hour and a half point because it felt mild personally and she nodded in agreement (<-I may be talking across threads here lol). It was my first time taking a 2cX with her personally (as in as a couple), but I had known OF her taking 2ce with others before. It wasn't even until the next day that I thought heeeeyyyyyy wait a minute! And asked her if she was even tripping because I was so fucked at the time I kinda assumed she was too, but in retrospect... anyway, I JUST now found out that the 2c's have a minimal effect on her compared to other people. - so when you say

but I wouldn't keep trying to take the 2C's to make it "punch through".

Please don't think that was ever my intention =) She gets something out of the experience, like she gets high enough to have repeated it (going through the pain of snorting 2ce many times) but I think it's mostly body high- visually and mentally she misses out I think we've figured out, while she experiences the mental benefits of mdXX's But yeah, just figured this out (and here I am asking questions =p) Not planning on wasting any more 2c's being stupd haha (And ho-ly SHIT can you get stupid on 40mg of 2ci! lol I got LUCKY she wasn't as fucked as I was, weed-a been lost in that sculpture park all night).

Think I covered everyone's comments. I TOTALLY agree with you all from an outside perspective- I would never ever recommend someone on that long a list of meds take any psychedelic, neehehehheeeeevvvvEEevvvvveeerr would I tell someone like that I didn't know that it was a good idea to do something like that. But, I've known her for years and she's done stuff personally I'm scared shitless to touch (5meo epic doses), and she's handled it all like a champ. (Also note, she's been on this list of meds as long as I have known her through all her witnessed drug use) Empathogens have shown themselves to be beneficial to her (as I also know them to be personally), and I see mescaline as natures crown champion empathogen. I didn't come here to see if she could get fucked up, I came here to see if she could share with me the full experience and healing effects that it can have when used in the right conditions.

Ok, enough rambling for me for now=p keep the opinions flowing! And thank you everyone so far who has chimed in =) We appreciate it greatly.

~Recap~ I'm not worried about negative effects as I've seen her take, well, everything, on this combo of meds to no ill effect. There was one bad trip she had on LSD but there were many more that went well. That instance was a matter of bad set and setting- I take good care of my friends though

Anyone with big ginormous brains full of drug knowledge out there who could confirm a bit further what to expect, as always, much appreciated! Really want to share this with her, mescaline has been a guiding light for me more than once in life when I found myself lost. (Cheezy sounding, whatever, I beat PTSD with it)

 

[Ph0r.W3-R-m4ny]

*edit* I was fuzzy on the details, I thought she had been on that list for years, but the sapharis and provigil were added ~6 months ago, the others had been there the whole time.