Hi all,
I couldn't find any information regarding which liver enzymes are responsible for metabolizing 2C-B in humans. Considering there has been very little research done on 2C-B, I won't be surprised if this information doesn't even exist.
Does anyone here happen to know the answer to this question?
Did you try a search on Google or Pubmed? There are a number of papers that show MAO is the major enzyme involved in 2C-B metabolism. Here's one.
J Forensic Sci. 2013 Jan;58(1):279-87. doi: 10.1111/j.1556-4029.2012.02289.x. Epub 2012 Oct 15.
Analysis of 4-bromo-2,5-dimethoxyphenethylamine abuser's urine: identification and quantitation of urinary metabolites.
Kanamori T, Nagasawa K, Kuwayama K, Tsujikawa K, Iwata YT, Inoue H.
Abstract
The metabolites of 4-bromo-2,5-dimethoxyphenethylamine (2C-B), a psychoactive drug with hallucinogenic activity, were investigated in a urine sample from a user of 2C-B. The urine sample was deconjugated enzymatically and the metabolites were recovered by liquid-liquid extraction. The extract was analyzed by gas chromatography/mass spectrometry after derivatization, and the results were used to identify and quantitate the metabolites. 4-Bromo-2,5-dimethoxyphenylacetic acid was the most abundant metabolite of 2C-B in human urine and accounted for 73% of the total amount of detected metabolites, followed by 4-bromo-2-hydroxy-5-methoxyphenylacetic acid (13% ) and 4-bromo-2,5-dimethoxyphenylethyl alcohol (4.5% ). According to the literature, the main metabolites of 2C-B in rat urine are N-(4-bromo-2-methoxy-5-hydroxyphenylethyl)acetamide and N-(4-bromo-2-hydroxy-5-methoxyphenylethyl)acetamide. However, these metabolites accounted for only a small proportion of the total amount of detected metabolites in human urine, which indicates that there are significant species-specific differences in the metabolism of 2C-B. 4-Bromo-2,5-dimethoxyphenylacetic acid, which was the most abundant metabolite in human urine, is thought to be generated by deamination of 2C-B by monoamine oxidase (MAO) followed by oxidation by aldehyde dehydrogenase. Our results suggest that MAO plays a crucial role in the metabolism of 2C-B in humans.
