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2C-* (2C-E/B primarily) alongside Tramadol/other opiates.

G

GZero

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I tested out my 2C-E last night, lovely stuff but can put you a bit on edge.

I happened to have some O-Desmethyltramadol to hand (which I gather is a primany tramadol metabolite) so I took 100mg orally, and in all honestly I felt fucking fantastic, the whole affair was one of the better psychedelic experiences I've ever had and I think it was due in no small part to the Tramadol, as it seems to eliminate any feelings of anxiety or body load and replaces them with a light buzz and mild euphoria.

Anyway, I'm a little worried about any potential interactions between the 2C-E and the Tramadol. Not being a pharmacologist myself I thought I'd ask here, are there any issues I need to bear in mind surrounding opiates and phenethylamines?

As it stand it's a combination I'm very keen to retry in the near future.

Thanks chaps! I look forward to your response.
 
i found opioids to seriously detract from the trip, like it was inhibited from reaching its full potential. i never took tramadol or o-desmethyltram while tripping though...

there should be information about this kinda stuff somewhere in the archives and other past threads though, because i know i've discussed this sort of thing in here many many years ago
 
Agreed. Would advise caution with combining tramadol itself with any stims/psyches as it has all kinds of iffy interactions. The O-desmethyltramadol is apparently more of a straight opiate without the SNRI and other properties of tramadol so is possibly less iffy for interactions. It has very limited use so far though so interactions may well just not be well enough known to have shown up yet. I'd definitely take it careful just for the fact that so little is known about dosing O-desmethyltramadol itself let alone how it reacts in combination. If it works like a straight opiate then it would probably be fun, admittedly :)
 
Another truly profound experience is under way.

I must do a write up of this O-desmethyltramadol, it really is some excellent stuff.

10mg 2C-E + 200mg O-desmethyltramadol makes for a wonderfully smooth, cloudy, trippy experiment.

2C-E really must remain my favourite phen, it feel so much more real, more organic than the others. So like LSD.
 
Gzero

what was the timing of the doses of 2C-E & O-desmethyltramadol, were they taken at once?
 
I insufflated the 2ce and dropped the O-desmethyltramadol at the same time. After getting over the first 10 minutes of burn from the 2ce it was plain sailing.

Took a little booster of the 2ce ~>5mg? orally about 15 mins ago, and I feel fucked. Perhaps too much.

Amazing shit, a true psychedelic. The visuals are strong, the body load is manageablel.
 
Any one have any more experiences along these lines? Just dropped some 2C-C and was given some tramadol with I might use after I come down with some valium
 
Like Peppersocks, I don't know but am personally worried about it. There could be interactions. I feel a little bit like the side effects of DXM feel and that is to me a sign not to mix with drugs that fuck with monoamines in general. Plus what happened to Shambles is a bit of a mystery to me and before there is a good explanation I don't think its worth trying out if I will get the same. LSD is much more promiscuous pharmacologically so other psychedelics may be safer. Again: not interested to find out the hard way.

Other normal 'clean' working opiates should be fine. Careful with valium though, the combo can suppress breathing etc. Not nice.

No other real facts here, but I do not take stimulants or psychedelics while on tramadol. FWIW
 
Yeah, wasn't planning on doing it unless any one had some solid proof it would be safe.
This is enough evidence for me to not.

I'm not that much of an idiot :p
 
I was not implying. :)

Glad that you are rather safe than sorry. Not everyone makes that very same judgement call.
 
Perhaps surprisingly, I actually didn't find 2Cs a problem with tram. I have used a few of them since being on my tramadol script (starting before the LSD incident - wouldn't have risked it otherwise) and other than a bit of potentiation they seemed to get along okay.

I would still advise against it though.

Mainly cos tramadol is so feckin' messy and unpredictable in combinations that it's just not worth the risk. But also as it's not a combo of any value. I only combined them cos I'm on a daily tram script and prior experience (before the LSD incident) suggested that they don't interact much for me. The tramadol adds absolutely nothing - no synergy or the like - but if I don't take it then I go into combined opioid and SNRI withdrawal which is not so great if you're tripping. I'm currently tapering the tram and intend to cut it out completely as it's just way too dangerous to take unless you give up recreational drugs.

Short answer: I noticed no serious interactions and also no reason to combine them (unless perhaps you take tramadol daily anyway). I would definitely recommend avoiding combining tramadol with pretty much anything else. Over 600 "severe" (ie potentially fatal) known interactions just with other prescription meds let alone recreational drugs. Not worth the risk, I'd say.
 
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