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25i-NBOMe

fice1991

Greenlighter
Joined
Feb 20, 2014
Messages
14
So I am getting 40 blotters of 25i-NBOMe at 1000 µg each. I hear it's a very dangerous drug but from everything I've read most people have often mistaken it for LSD and have taken much more than they should have.

I am getting it from a reliable source so I know it's good. Here's what wiki said about it:

25I-NBOMe is potent, being active in sub-milligram doses. A common dose of the hydrochloride salt is 600–1,200 µg. The UK Advisory Council on the Misuse of Drugs states that a common dose is between 50 and 100 µg,[5] although other sources indicate that these figures are incorrect; Erowid tentatively suggests that the threshold dosage for humans is 50–250 µg, with a light dose between 200–600 µg, a common dose at 500–800 µg, and a strong dose at 700–1500 µg.[18] At this level of potency, it is almost impossible to accurately measure a single dose of the powder form, and attempting to do so may put the user at risk of overdose.[5]


I don't plan on taking huge doses or anything. I would just want to take the minimum and experience the threshold dose and then take it slowly from there. I am definitely not taking long quantities for my first time.

I know it can be dangerous but as long as I don't take too much I should be fine right? I'm talking low doses likle 50
µg~300µg.

I've done 2ci before and it was pretty badass.

Some opinions? I'm getting it for super cheap so might as well lol. Again I don't plan on taking huge doses, going to take it Really slow/small at first.
 
I don't think there is any danger to my knowledge with 25I-NBOMe if the drug is taken if the dose is kept to 1500ug or less....unless this analogue has some particularly unique property. It is said to be a full agonist, but even with my limited understanding, I am not sure that makes it dangerous if you don't overdose on the stuff.
 
I don't think there is any danger to my knowledge with 25I-NBOMe if the drug is taken if the dose is kept to 1500ug or less....unless this analogue has some particularly unique property. It is said to be a full agonist, but even with my limited understanding, I am not sure that makes it dangerous if you don't overdose on the stuff.

That's exactly what I'm thinking. The people who OD'd didn't know it was 25i, they thought it was LSD so they took a lot. I've read articles from states all over the country. I would never sell the stuff to people as LSD, because in high doses the stuff is definitely dangerous. But like I said I plan on experiencing the effects at lowerrr ranges and then moving up.

I am one of those people who likes to be careful lol.
 
as you titrate up your dose to find the amount you are most comfortable with
I have found it necessary to leave 72hours between experiments
or else you get less effect from it,
and may later (after more than 72 hours) have an unpleasant surprise at the intensity.
 
People seem to be taking 25i at dosages between 300-1500ug without any acute problems, yes. Nobody knows if it's dangerous though. Phenethylamines and especially 25i are extremely potent in areas of the brain that aren't very well understood, areas which are possibly non psychoactive and the damage could be silent. It's really a big risk that many of us take to get high.
 
From what I read I decided it is a substance I personally would not like to ingest. Its just too dangerous IMO and I am very experienced.

I would probably cut the dose in half.

Maybe if someone I knew took it and I babysitted them during their trip, I would consider it but frankly I don't know much about it and from what I have read it scares the shit out of me because its the only substance of that type that I know you can easily OD on and its not a risk I am willing to take.

I read the come up is a bit harsh and the visuals are intense. So I would imagine once you adjust it would be smooth sailing. I know its dirt cheap but all the same I have no interest in risking my life or sanity at this time.

But I am interested in hearing how it goes. I am not ruling it out, but this is not the proper time in my life. That is for sure.
 
People seem to be taking 25i at dosages between 300-1500ug without any acute problems, yes. Nobody knows if it's dangerous though. Phenethylamines and especially 25i are extremely potent in areas of the brain that aren't very well understood, areas which are possibly non psychoactive and the damage could be silent. It's really a big risk that many of us take to get high.
usually fatal od means kidney liver fatal damage. substances and drugs are ussualy hepatotoxic if its possible to od,or hypertensive . now full aginist means its binds to aspecific receptor only , so its not brain damage that usually leads to fatality
 
usually fatal od means kidney liver fatal damage. substances and drugs are ussualy hepatotoxic if its possible to od,or hypertensive . now full aginist means its binds to aspecific receptor only , so its not brain damage that usually leads to fatality

Agonist means 'activate'.

Most cases of death involving 25i started and ended in seizure. Hepatoxicity is a completely different mechanism than by which 25i is dangerous, as far as i'm concerned. 25i is incredibly potent at the p-ERK signal passageway of 5ht2a, and over activation of this subset seems to be the cause for death.
 
how would they ever determine that p-ERK caused death,
mostly the 5ht2a is involved in triggering an up-shift in Ca++ movement, while p-ERK is a complex protein synthesis issue.

anyway, the kind of euphoria that people can get at higher doses can scare people to death in their impressionable psychedelic state, and ignorance is at play in most of the cases where people are dying. All of the stories are filtered through public media, and seem incomplete as well as biased.

there are people in the community that are taking several mg and proudly broadcasting their survival which is not that smart, but it supports the position that confidence can take.

Also some high doses are not as high as they seem since tolerance is at play - especially when a sequence of blotters is ingested, in which the first set diminishes the second set and any that follow. Also I think chewing is more effective than resting it buccally, again for the tolerance which can set in during a prolonged ingestion process
 
It's not that it's been determined. It just seems to be likely since the 25i is drastically so much more potent at p-erk than any other signal path. 5ht2a is involved in ca++, p-erk, aa, and many other signal paths and while 5ht2a may mostly be involved with ca++, i think the reason that psychedelics do what they do is largely due to the changing of the whole role of 5ht2a and it's triggers.
 
its my favorite psychedelic, pure eye candy. amazing visuals, zero fear. not much of that thinking about your life and really heavy shit like "why am i alive" "what am i to do with my life" "my personal relationship"….just enjoying visuals is what its about. I've even taken it while fully depressed and emotionally upset and I was fine and had a positive trip.
 
Yup, it's a really nice trip. 25I is a very recreational substance (or shallow, depending on who you are)

It's not true that we can fully attribute the many 25I deaths to overdosing alone, because anecdotally some people seem to have allergic reactions to NBOMe's at normal doses. Something sketchy seems to be going on pharmacologically that we don't what is.
 
In regard to the opening post: treat it with respect, a 1/4 tab may not be enough for you to feel anything but 1/2 tab may be close to your sweet spot. tabs are NOT a perfect science and we all know the product can lay and dry unevenly. I do not trust tabs. Pupnik has described some variability in his 25I tabs. Then again set and setting can play a role in the trip as well. Personal health may have a role to play as well... most people feel elevating magnesium and potassium levels naturally or with supplements is advisable. Magnesium is very helpful and most Americans do not get enough of it in an average diet. Just do a google search on it and your will see. I also take Icarin as a supplement daily as I do feel it has helped me motivate for my work outs. It is natural vasco-diolator I am very healthy, I consume a ton of natural potassium and magnesium because of my odd gluten free lifestyle..... as does my wife. No one can give you advice on how much to take as it is against the rules of the BL we simply educate on the reality, it is of course your decision and your risk.

Personally I enjoy this substance, but I am very restrained. The most I could see myself doing is maybe 6 to 7 trips max in a years time, in all honesty probably less. My sweet spot is right around 1 mg sublingually and probably 700 to 800 mg insufulated but I have not proven that out just yet. Pupnik, I think your advise on tolerance and wait time between trips while true for you is not true for everyone. Most people would develop more of a tolerance then what you have described in other posts. Most people say a week maybe enough but really 2 weeks between trips is more advisable for people who are trying to find their sweet spot, while some others like myself would advise a month in between trips, once you find your sweet spot.

I am very healthy, but I am not a teenager either, and while I have never had a hang over, I can kind of feel it in my work outs over the next few days after an experience. I feel great mentally the next day, I don't feel tired, and normally I have a pretty good day. I don't work out that day, but then the 2nd day after the trip when I go back to training, I can feel that my body has been put through something.....

Now I am aware of my body, I am in damn good shape, so maybe I am more aware then others, but it does take a small physical toll.... less then MDMA by my estimates, but it is still there.... perhaps lingering vascoconstriction. My best description is it can be a bit harder to bust out my normal 25 reps, I back it down to 20 reps when I am building muscle.

It is a very interesting substance, someone on the Blue detailed how it could be used as a energizing cure for Migrain headaches at a low level dose think 100 mics.... because it is vascoconstrictive.

There are many of us that have had positive experiences, I find it not only visual but really pretty euphoric. My wife has a lower dose sweet spot then me... probably at around 700 mics but she is only 105 lbs. I am 5' 11' and a solid 185lbs. There are others that describe a 2 dose trip lasting close to 20 hours and having some excruciating moments.


My experiences are my own and I do not have tabs, simply the powder purchased long before it was illegal. I agree with Fagott on the sketchiness for some, when I first tired the substance, it was not so popular and there was only 1 negative near fatal low dose report and erowid. For me the positives and legal status made it worth the risk, now I may have never tried it with all the bad reports.

I do think for some people it clearly pulls a trigger, some people have a bad reaction to MDMA, where they lose the ability to urinate and basically poision themselves. I know on higher doses of MDMA it took some real concentration for me to urinate despite being well hydrated. It was like I knew I had to go..... but wound up standing there for quite a while. In many ways I liken 25I more to good strong pure MDMA from back in the day. Clearly though far less room for error and a more formidable dose response curve.

Still though while at one point I had a BLAST on a 10 strip of LSD I would have never ever ever considered taking 10 E pills. I had the money and access to the product back in the day too. 3 bombs at once was an increadible trip when it came to my gelcaps. Never once felt the need to push it any further cause the 2 to 5 days after were a mess.
 
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good points weedazoid.
my interest in lower doses (which may also shorten tolerance intervals) has a lot to do with looking for something that can replace alcohol (which in the form of red wine is nearly a daily medicine - but boring and not that cheap) and weed (which I have not smoked in years but have liked a lot and not cheap either)
so
the long and the short of it is
this is too strong for daily use or even ever other daily use, and quarters are at least as strong as a joint or 2 glasses of wine.
but somehow I am mixing it in to my weekly toxification - and if I really needed something daily, there is always some salvia around, and usually some red wine.
and you just reminded me to do some pushups.
so
1,2,3,4....50
 
LOL you are a very interesting individual Pupnik. It is interesting that you are taking this on a different route then most looking for a small dose 'regimen' for simple easy going pleasure. It sounds like you are a fairly responsible poster even though at a glance some would look at you as a kind of radical.

It may indeed have something to do with your low tolerance levels, it would not be for me but it seems to work for you
 
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