25c-nbome - Triggers H1 H2 receptors

[DylanG204]

I had made a solution of 400 ug/0.1ml , Later on my nasal administration device completley stopped working .
so i think it gave me a dose way larger than expected hence the extreme come up within seconds of the spray.

Later on i expereinced mild-extreme vasoconstriction , and about 3 hours into the experience a massive histamine realease ( from excess NBOME activating H1,H2 ) heres a link
http://www.livestrong.com/article/78864-effects-excess-histamine-release/
Both of my upper thigs were swollen massive , my feet were pretty big , and i had pressure in my head . but most of the effects were on my legs down.

i have sucessfully tripped off the same material with amazing results , so i am certain it hasto do with overdose/ saturation point of receptors

any insights or similar experiences??

 

[Solipsis]

It does sound like an allergic reaction, did you also get itchy? I'm not sure how many or what pattern of allergic symptoms presents itself in a given situation. I have become allergic to something in the previous months and am now prone to itch, I have not figured out the cause or perhaps if some root of it lies in drug use. Taking morphine curiously enough did not make me itch, it didn't even give a pleasant opiate itch so I guess you can call me dumbfounded.

As I understand it there is no real answer from science why some people only get itch and others get anaphylaxis when an allergic reaction happens...

Also I know of a guy who occasionally seems to get a swollen face / mouth from GBL use but nothing that seems to indicate actual topical irritation. Also a case that has not been solved by a clever fellow.

I recall some NBOMe analogue of ketanserin being suggested in PD recently and I made clear my worries about these NBOMe compounds activating things like adrenergic and histaminergic receptors. It seems if they get thrown off freaky things can happen, but vasoconstriction is relatively predictable if we compare it to histamine involvement which leaves me clueless.

 

[sekio]

I don't expect most NBOMe compounds to have appreciable action at the histamine receptors at normal physiological concentrations. They are very selective for 5-HT2a/c in terms of affinity.

Do remember that overdoses of psychedlics can cause massive vasoconstriction, swelling et cetera. This is intrinsic to their capacity to activate serotonin receptors, not histamine. It's happened before with some 2c- compounds, DOx, and BR-DFLY.

 

[Solipsis]

I don't expect most NBOMe compounds to have appreciable action at the histamine receptors at normal physiological concentrations. They are very selective for 5-HT2a/c in terms of affinity.

Do remember that overdoses of psychedlics can cause massive vasoconstriction, swelling et cetera. This is intrinsic to their capacity to activate serotonin receptors, not histamine. It's happened before with some 2c- compounds, DOx, and BR-DFLY.

So some non- 2A subtype is the culprit? Because I've had terrible cold feet from 25D-NBOMe without things like tachycardia or any other stimulant side-effect. It was really odd. Normally if the picture adds up I know how to call it, and I know when it's time to abandon personal investigations. When a compound comes up out of the blue like that it really puts me off. And I was at very low, threshold-y dosage levels.

However it is much appreciated that you are clearing up the alleged pharmacology behind it, at least you can sell me on the swelling being from vasoconstriction. It's like the lymph vessels are too constricted to release the building fluids or something like that is it not? Always good to be more and more in the know

 

[sekio]

As far as I recall, 5-HT2a agonism itself is vasoconstrictive to an extent. 5-HT4 is reportedly one of the receptors invoved in the cardiac stimulant effects of serotonergics. The "less selective" phenethylamines are also alpha/beta adrenergic agonists in various proportions.

 

[DylanG204]

those were some good replys and make perfect sence , thanks alot !! much appreciated