tregar
Bluelighter
Trip report with 250mg of mescaline + 250ug of HPBCD complexed 25i-nbome.
Later in the night, (after the effects of a "test-dosage" of 80mg mescaline + 200ug of HPBCD complexed 25i-nbome had completely worn off some 6 hours later)....then boosted the mescaline dose to 250mg and added 250ug of HPBCD complexed 25i-nbome under tongue again for 20 minutes at 1am in the morning. ++++ experience, with this combined dosage lasting a full 8 hours, took 2 ben*dryls to finally fall asleep at 9 in the morning, eyes closed even this late in the morning, seeing Chinese dragons, complex machinery, just went on and on, one image after another.
The visuals unlike with 25i-nbome alone, made perfect sense when combined with mescaline, way more visually powerful than acid, with eyes closed saw brightly lit landscapes of un-imaginable beauty Japanese in origin, geometrics spinning in neon green, purple, blue, I felt like Shulgin had said in his mescaline entry in PIHKAL, nothing seemed more important than getting closer to God. Feel immense Love & peace and Joy and the visuals are second to none, indescribable beauty and complexity, mind space of acid + mescaline combined. No other psychedelics ever needed, this is the ultimate combination imho. I can't even begin to describe the open-eyed visuals, looking at just a rock caused me to see an ocean of things inside it. Heaphones on the whole time, music another world entirely. At one point, in my peripheral vision, the tv screen went from dull to bright and it was so dramatic it seemed as if another portal to a new dimension was opened. So much open-eyed "meaningful" visual activity going on I can't even begin to describe, so very very powerful. Layers of the self exposed like peeling an onion, deep memories recalled. Absolutely no side effects, no nausea, no GI upset, no nothing, no rapid heart, in fact felt better than 25i-nbome alone. I felt a tiny hint of very faint nausea when the mescaline kicked in for a short while (10 to 15 minutes), that was it.
In my opinion, this is the only way to take 25i-nbome, along with mescaline, the experience being even more visual than 550ug of 25i-nbome alone...not only that but a guide becomes apparent for the trip, becomes just as "mind-manifesting" as acid with deep meaning and complexity, highly spiritual. It's the only way I will do it in the future.
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After studying all the different 5-HT receptor sites on wikipedia and at neruopharmacology sites, I discovered that 5-HT6 agonism (provided by 25i-nbome) also leads to activation of cAMP signalling pathways through adenylate cyclase stimulation, 5-HT6 agonism also stimulates pro-cognitive activities. This is similar to 5-HT7 stimulation provided by the mystically popular DMT, 5-MEO-DMT, and LSD. 5-HT7 receptor affinity stimulates cAMP activity and the reward system, seeming to be implicated in overall transcendent psychedelic action. The mystically popular Mescaline, psilocin & DMT have significant affinity for 5-HT1A receptors.
25i agonizes the following receptors [the lower the number, the greater the affinity]
5-HT2A (0.044), 5-HT2C (2), 5-HT6 (73), 5-HT2B (231), u opiate (82), kappa opiate [288]
Mescaline agonizes the following receptors [4.00 = maximum affinity, 0.00 = no affinity]:
Alpha2c (4.00), 5-HT2B (3.97), 5-HT1A (3.61) Imidazoline1 (3.44), 5-HT1E (3.16), alpha 2a (2.92) and very poorly agonizes 5-HT2A & 5-HT2C.
So in other words, 25i-nbome + mescaline looks like this as far as affinity agonism:
5-HT2A, Alpha2c, 5-HT2B, 5-HT2C, 5-HT1A, 5-HT1E, 5-HT6, u opiate, kappa opiate, Imidazoline1, alpha2a.
(Imidazoline1 agonism lowers blood pressure similar to Clonidine)
Later in the night, (after the effects of a "test-dosage" of 80mg mescaline + 200ug of HPBCD complexed 25i-nbome had completely worn off some 6 hours later)....then boosted the mescaline dose to 250mg and added 250ug of HPBCD complexed 25i-nbome under tongue again for 20 minutes at 1am in the morning. ++++ experience, with this combined dosage lasting a full 8 hours, took 2 ben*dryls to finally fall asleep at 9 in the morning, eyes closed even this late in the morning, seeing Chinese dragons, complex machinery, just went on and on, one image after another.
The visuals unlike with 25i-nbome alone, made perfect sense when combined with mescaline, way more visually powerful than acid, with eyes closed saw brightly lit landscapes of un-imaginable beauty Japanese in origin, geometrics spinning in neon green, purple, blue, I felt like Shulgin had said in his mescaline entry in PIHKAL, nothing seemed more important than getting closer to God. Feel immense Love & peace and Joy and the visuals are second to none, indescribable beauty and complexity, mind space of acid + mescaline combined. No other psychedelics ever needed, this is the ultimate combination imho. I can't even begin to describe the open-eyed visuals, looking at just a rock caused me to see an ocean of things inside it. Heaphones on the whole time, music another world entirely. At one point, in my peripheral vision, the tv screen went from dull to bright and it was so dramatic it seemed as if another portal to a new dimension was opened. So much open-eyed "meaningful" visual activity going on I can't even begin to describe, so very very powerful. Layers of the self exposed like peeling an onion, deep memories recalled. Absolutely no side effects, no nausea, no GI upset, no nothing, no rapid heart, in fact felt better than 25i-nbome alone. I felt a tiny hint of very faint nausea when the mescaline kicked in for a short while (10 to 15 minutes), that was it.
In my opinion, this is the only way to take 25i-nbome, along with mescaline, the experience being even more visual than 550ug of 25i-nbome alone...not only that but a guide becomes apparent for the trip, becomes just as "mind-manifesting" as acid with deep meaning and complexity, highly spiritual. It's the only way I will do it in the future.
------------------------------------------------------------------------------
After studying all the different 5-HT receptor sites on wikipedia and at neruopharmacology sites, I discovered that 5-HT6 agonism (provided by 25i-nbome) also leads to activation of cAMP signalling pathways through adenylate cyclase stimulation, 5-HT6 agonism also stimulates pro-cognitive activities. This is similar to 5-HT7 stimulation provided by the mystically popular DMT, 5-MEO-DMT, and LSD. 5-HT7 receptor affinity stimulates cAMP activity and the reward system, seeming to be implicated in overall transcendent psychedelic action. The mystically popular Mescaline, psilocin & DMT have significant affinity for 5-HT1A receptors.
25i agonizes the following receptors [the lower the number, the greater the affinity]
5-HT2A (0.044), 5-HT2C (2), 5-HT6 (73), 5-HT2B (231), u opiate (82), kappa opiate [288]
Mescaline agonizes the following receptors [4.00 = maximum affinity, 0.00 = no affinity]:
Alpha2c (4.00), 5-HT2B (3.97), 5-HT1A (3.61) Imidazoline1 (3.44), 5-HT1E (3.16), alpha 2a (2.92) and very poorly agonizes 5-HT2A & 5-HT2C.
So in other words, 25i-nbome + mescaline looks like this as far as affinity agonism:
5-HT2A, Alpha2c, 5-HT2B, 5-HT2C, 5-HT1A, 5-HT1E, 5-HT6, u opiate, kappa opiate, Imidazoline1, alpha2a.
(Imidazoline1 agonism lowers blood pressure similar to Clonidine)
